(Q37967032)

26 August 2017

Programmed cell removal: a new obstacle in the road to developing cancer (English)

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26 August 2017

3

Irving L Weissman

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26 August 2017

Mark P Chao

1

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PubMed ID

22158022

26 August 2017

Ravindra Majeti

series ordinal

2

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PubMed ID

22158022

26 August 2017

language of work or name

English

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publication date

8 December 2011

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26 August 2017

Nature Reviews Cancer

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26 August 2017

12

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26 August 2017

58-67

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26 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nrc3171

26 August 2017

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cites work

Apoptosis and cancer: the genesis of a research field

1 reference

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages

21 January 2018

1 reference

Beginnings of a good apoptotic meal: the find-me and eat-me signaling pathways

21 January 2018

1 reference

Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues

21 January 2018

1 reference

Clearance of apoptotic cells: getting rid of the corpses.

21 January 2018

1 reference

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

21 January 2018

1 reference

Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal.

21 January 2018

1 reference

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

21 January 2018

1 reference

Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis

21 January 2018

1 reference

UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis

21 January 2018

1 reference

Engulfment of apoptotic cells: signals for a good meal

21 January 2018

1 reference

Clearance of apoptotic cells: implications in health and disease

21 January 2018

1 reference

A blast from the past: clearance of apoptotic cells regulates immune responses.

21 January 2018

1 reference

Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums

21 January 2018

1 reference

The innate immune system and the clearance of apoptotic cells.

21 January 2018

1 reference

Role of phosphatidylserine exposure and sugar chain desialylation at the surface of influenza virus-infected cells in efficient phagocytosis by macrophages

21 January 2018

1 reference

Bridging effect of recombinant human mannose-binding lectin in macrophage phagocytosis of Escherichia coli

21 January 2018

1 reference

Complement-dependent clearance of apoptotic cells by human macrophages

21 January 2018

1 reference

C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells

21 January 2018

1 reference

The role of phosphatidylserine in recognition of apoptotic cells by phagocytes

21 January 2018

1 reference

Corpse clearance defines the meaning of cell death

21 January 2018

1 reference

21 January 2018

Apoptotic cell removal

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Annexin I Is an Endogenous Ligand that Mediates Apoptotic Cell Engulfment

21 January 2018

1 reference

Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte

21 January 2018

1 reference

Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment

21 January 2018

1 reference

CD200 and membrane protein interactions in the control of myeloid cells

21 January 2018

1 reference

Cancer stem cells, CD200 and immunoevasion

21 January 2018

1 reference

Down-regulation of the macrophage lineage through interaction with OX2 (CD200)

21 January 2018

1 reference

Monoclonal antibody-mediated CD200 receptor signaling suppresses macrophage activation and tissue damage in experimental autoimmune uveoretinitis

21 January 2018

1 reference

PAI-1 inhibits neutrophil efferocytosis

21 January 2018

1 reference

Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis

21 January 2018

1 reference

Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice

21 January 2018

1 reference

Vascular functions of the plasminogen activation system

21 January 2018

1 reference

Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells

21 January 2018

1 reference

Role of CD47 as a marker of self on red blood cells

21 January 2018

1 reference

CD47 (integrin-associated protein) engagement of dendritic cell and macrophage counterreceptors is required to prevent the clearance of donor lymphohematopoietic cells

21 January 2018

1 reference

Reduced expression of CD47 during murine red blood cell (RBC) senescence and its role in RBC clearance from the circulation.

21 January 2018

1 reference

Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis

21 January 2018

1 reference

Thrombospondin 1 Is an Autocrine Negative Regulator of Human Dendritic Cell Activation

21 January 2018

1 reference

Endogenous thrombospondin-1 is a cell-surface ligand for regulation of integrin-dependent T-lymphocyte adhesion.

21 January 2018

1 reference

Autocrine regulation of T cell motility by calreticulin-thrombospondin-1 interaction.

21 January 2018

1 reference

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

21 January 2018

1 reference

CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells.

21 January 2018

1 reference

Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum.

21 January 2018

1 reference

Pathophysiological roles of calreticulin in autoimmune disease

21 January 2018

1 reference

Systemic exposure to irradiated apoptotic cells induces autoantibody production

21 January 2018

1 reference

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

21 January 2018

1 reference

Calreticulin exposure dictates the immunogenicity of cancer cell death

21 January 2018

1 reference

Defects in the disposal of dying cells lead to autoimmunity

21 January 2018

1 reference

CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis

21 January 2018

1 reference

Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma

21 January 2018

1 reference

Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia

21 January 2018

1 reference

Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells

21 January 2018

1 reference

Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47

21 January 2018

1 reference

Annexin 1: the new face of an old molecule

21 January 2018

1 reference

Three isoforms of annexin I are preferentially expressed in normal esophageal epithelia but down-regulated in esophageal squamous cell carcinomas

21 January 2018

1 reference

Dysregulation of the annexin family protein family is associated with prostate cancer progression

21 January 2018

1 reference

Differentiation-dependent expression of phosphatidylserine in mammalian plasma membranes: quantitative assessment of outer-leaflet lipid by prothrombinase complex formation

21 January 2018

1 reference

Binding of annexin V to a human ovarian carcinoma cell line (OC-2008). Contrasting effects on cell surface factor VIIa/tissue factor activity and prothrombinase activity

21 January 2018

1 reference

Enhanced exposure of phosphatidylserine in human gastric carcinoma cells overexpressing the half-size ABC transporter BCRP (ABCG2).

21 January 2018

1 reference

Surface exposure of phosphatidylserine in pathological cells

21 January 2018

1 reference

Evaluation of cell surface expression of phosphatidylserine in ovarian carcinoma effusions using the annexin-V/7-AAD assay: clinical relevance and comparison with other apoptosis parameters

21 January 2018

1 reference

Antibodies selected from combinatorial libraries block a tumor antigen that plays a key role in immunomodulation

21 January 2018

1 reference

Immune modulation by melanoma and ovarian tumor cells through expression of the immunosuppressive molecule CD200.

21 January 2018

1 reference

CD200 is a new prognostic factor in multiple myeloma

21 January 2018

1 reference

CD200 as a prognostic factor in acute myeloid leukaemia.

21 January 2018

1 reference

CD200 expression on tumor cells suppresses antitumor immunity: new approaches to cancer immunotherapy

21 January 2018

1 reference

The immunosuppressive surface ligand CD200 augments the metastatic capacity of squamous cell carcinoma.

21 January 2018

1 reference

Dysregulation of CD47 and the ligands thrombospondin 1 and 2 in multiple myeloma

21 January 2018

1 reference

CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia

21 January 2018

1 reference

Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organization

21 January 2018

1 reference

Type 3 repeat/C-terminal domain of thrombospondin-1 triggers caspase-independent cell death through CD47/alphavbeta3 in promyelocytic leukemia NB4 cells

21 January 2018

1 reference

The proliferating role of insulin and insulin-like growth factors in cancer

21 January 2018

1 reference

Induction of vascular endothelial growth factor and matrix metalloproteinase-9 via CD47 signaling in neurovascular cells.

21 January 2018

1 reference

Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47.

21 January 2018

1 reference

CD47 augments Fas/CD95-mediated apoptosis.

21 January 2018

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Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling

21 January 2018

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Stem cells, cancer, and cancer stem cells

21 January 2018

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Impaired p53 expression, function, and nuclear localization in calreticulin-deficient cells

21 January 2018

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ER chaperones in mammalian development and human diseases

21 January 2018

1 reference

Clinicopathological significance of calreticulin in breast invasive ductal carcinoma.

21 January 2018

1 reference

Identification of calreticulin as a prognosis marker and angiogenic regulator in human gastric cancer.

21 January 2018

1 reference

p53 mutations in human cancers

21 January 2018

1 reference

Mammalian stress response: induction of the glucose-regulated protein family

21 January 2018

1 reference

The role of the unfolded protein response in tumour development: friend or foe?

21 January 2018

1 reference

The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death

21 January 2018

1 reference

ERP57 membrane translocation dictates the immunogenicity of tumor cell death by controlling the membrane translocation of calreticulin

21 January 2018

1 reference

Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression

21 January 2018

1 reference

The low-density lipoprotein receptor-related protein regulates cancer cell survival and metastasis development

21 January 2018

1 reference

Gene transfer of vasostatin, a calreticulin fragment, into neuroendocrine tumor cells results in enhanced malignant behavior

21 January 2018

1 reference

Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth

21 January 2018

1 reference

The leukemic fusion gene AML1-MDS1-EVI1 suppresses CEBPA in acute myeloid leukemia by activation of Calreticulin

21 January 2018

1 reference

Unfolded protein response suppresses CEBPA by induction of calreticulin in acute myeloid leukaemia

21 January 2018

1 reference

HLA class I antigen down-regulation in primary laryngeal squamous cell carcinoma lesions as a poor prognostic marker.

21 January 2018

1 reference

Integrin-associated protein (CD47) and its ligands

21 January 2018

1 reference

CD47 in the immune response: role of thrombospondin and SIRP-alpha reverse signaling

21 January 2018

1 reference

Functions and molecular mechanisms of the CD47-SIRPalpha signalling pathway

21 January 2018

1 reference

Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice.

21 January 2018

1 reference

Physiological migration of hematopoietic stem and progenitor cells.

21 January 2018

1 reference

Stem cell research: paths to cancer therapies and regenerative medicine

21 January 2018

1 reference

Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy

21 January 2018

1 reference

21 January 2018

Surfing the p53 network

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p53 in health and disease

21 January 2018

1 reference

Diagnosing and exploiting cancer's addiction to blocks in apoptosis

21 January 2018

1 reference

Somatic mutations in the death domain of the Fas (Apo-1/CD95) gene in gastric cancer.

21 January 2018

1 reference

Gene expression profiling of Polycomb, Hox and Meis genes in patients with acute myeloid leukaemia.

21 January 2018

1 reference

The Hox genes and their roles in oncogenesis.

21 January 2018

1 reference

Hox genes in hematopoiesis and leukemogenesis.

21 January 2018

1 reference

PTEN loss in the continuum of common cancers, rare syndromes and mouse models.

21 January 2018

1 reference

IAP-targeted therapies for cancer

21 January 2018

1 reference

Annexin A1 down-regulation in head and neck cancer is associated with epithelial differentiation status.

21 January 2018

1 reference

Calreticulin Is at the Surface of Circulating Neutrophils and Uses CD59 as an Adaptor Molecule

21 January 2018

1 reference

Integrin-Associated Protein Binding Domain of Thrombospondin-1 Enhances Insulin-Like Growth Factor-I Receptor Signaling in Vascular Smooth Muscle Cells

21 January 2018

1 reference

Calreticulin exposure is required for the immunogenicity of γ-irradiation and UVC light-induced apoptosis

21 January 2018

1 reference

Distribution of the Immune Inhibitory Molecules CD200 and CD200R in the Normal Central Nervous System and Multiple Sclerosis Lesions Suggests Neuron-Glia and Glia-Glia Interactions

21 January 2018

1 reference

The clearance of apoptotic cells in the liver is mediated by the asialoglycoprotein receptor

21 January 2018

1 reference

Constitutive apoptosis in human neutrophils requires synergy between calpains and the proteasome downstream of caspases

31 March 2020

1 reference

Cell-surface exposure of phosphatidylserine correlates with the stage of fludarabine-induced apoptosis in chronic lymphocytic leukemia and expression of apoptosis-regulating genes

31 March 2020

1 reference

CD200/OX2, a cell surface molecule with immuno-regulatory function, is consistently expressed on hairy cell leukaemia neoplastic cells

31 March 2020

1 reference

CD200: a putative therapeutic target in cancer

31 March 2020

1 reference

Evidence of a role for CD200 in regulation of immune rejection of leukaemic tumour cells in C57BL/6 mice

31 March 2020

1 reference

Calnexin, calreticulin and the folding of glycoproteins

31 March 2020

1 reference

Mutations of tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and receptor 2 (TRAIL-R2) genes in metastatic breast cancers

31 March 2020

1 reference

12 December 2020

Rare loss-of-function mutation of a death receptor gene in head and neck cancer

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12 December 2020

Mutations in the Fas antigen in patients with multiple myeloma.

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12 December 2020

Alterations of the DR5/TRAIL receptor 2 gene in non-small cell lung cancers

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12 December 2020

Association of tapasin and HLA class I antigen down-regulation in primary maxillary sinus squamous cell carcinoma lesions with reduced survival of patients

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12 December 2020

In vivo expression of alternatively spliced forms of integrin-associated protein (CD47)

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12 December 2020

Monoclonal antibody against human ovarian tumor-associated antigens.

1 reference

12 December 2020

Somatic Fas mutations in non-Hodgkin's lymphoma: association with extranodal disease and autoimmunity.

1 reference

12 December 2020

Changes in expression of differentiation markers between normal ovarian cells and derived tumors.

1 reference

12 December 2020

Elevated expression of phosphatidylserine in the outer membrane leaflet of human tumor cells and recognition by activated human blood monocytes

1 reference

12 December 2020

Nucleotide substitution in the ectodomain of trail receptor DR4 is associated with lung cancer and head and neck cancer

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12 December 2020

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12 December 2020

CD200 is induced by ERK and is a potential therapeutic target in melanoma

1 reference

12 December 2020

Loss of annexin 1 correlates with early onset of tumorigenesis in esophageal and prostate carcinoma

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12 December 2020

Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells

1 reference

12 December 2020

Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin

1 reference

12 December 2020

Calreticulin and calreticulin fragments are endothelial cell inhibitors that suppress tumor growth

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC3171

1 reference

26 August 2017

1 reference

PubMed ID

22158022