(Q38021518)

English

Corticosteroid resistance and novel anti-inflammatory therapies in chronic obstructive pulmonary disease: current evidence and future direction.

scientific article published on July 2012

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scholarly article

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22731962%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Corticosteroid resistance and novel anti-inflammatory therapies in chronic obstructive pulmonary disease: current evidence and future direction (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22731962%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

chronic obstructive pulmonary disease

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22731962%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22731962%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

author name string

Omar S Usmani

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22731962%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

language of work or name

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based on heuristic

inferred from title

publication date

1 July 2012

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22731962%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22731962%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

72

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22731962%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

10

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22731962%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1299-1312

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22731962%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Chronic obstructive pulmonary disease: a growing but neglected global epidemic

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Global burden of COPD: risk factors, prevalence, and future trends

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Role of oxidants/antioxidants in smoking-induced lung diseases

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Beyond corticosteroids: future prospects in the management of inflammation in COPD.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Chronic obstructive pulmonary disease: molecular and cellularmechanisms

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Immunology of asthma and chronic obstructive pulmonary disease

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Cellular and structural bases of chronic obstructive pulmonary disease

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Multicentre randomised placebo-controlled trial of inhaled fluticasone propionate in patients with chronic obstructive pulmonary disease. International COPD Study Group.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Long-term effects of inhaled corticosteroids on FEV1 in patients with chronic obstructive pulmonary disease. A meta-analysis

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Effect of discontinuation of inhaled corticosteroids in patients with chronic obstructive pulmonary disease: the COPE study

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Withdrawal of fluticasone propionate from combined salmeterol/fluticasone treatment in patients with COPD causes immediate and sustained disease deterioration: a randomised controlled trial

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Inhaled corticosteroids in COPD: a controversy

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Growth hormone response to growth hormone-releasing hormone is reduced in adult asthmatic patients receiving long-term inhaled corticosteroid treatment

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Bone ultrasonometric features and growth hormone secretion in asthmatic patients during chronic inhaled corticosteroid therapy

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Systemic adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysis

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Cluster analysis and clinical asthma phenotypes.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Current controversies and future perspectives in chronic obstructive pulmonary disease

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Asthma quality of life during 1 year of treatment with budesonide with or without formoterol.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Interaction between glucocorticoids and beta2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Effectiveness of fluticasone propionate and salmeterol combination delivered via the Diskus device in the treatment of chronic obstructive pulmonary disease

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Maintenance therapy with budesonide and formoterol in chronic obstructive pulmonary disease

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Impact of salmeterol/fluticasone propionate versus salmeterol on exacerbations in severe chronic obstructive pulmonary disease

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Methodological issues in therapeutic trials of COPD.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Pneumonia risk in COPD patients receiving inhaled corticosteroids alone or in combination: TORCH study results.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

The influence of smoking on the treatment response in patients with asthma

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Smoking and lung function of Lung Health Study participants after 11 years.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy study

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Corticosteroids: the drugs to beat

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Glucocorticosteroids: current and future directions

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Lung deposition of BDP/formoterol HFA pMDI in healthy volunteers, asthmatic, and COPD patients

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Decreased histone deacetylase activity in chronic obstructive pulmonary disease.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Ligand-independent phosphorylation of the glucocorticoid receptor integrates cellular stress pathways with nuclear receptor signaling

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Steroid receptor phosphorylation: a key modulator of multiple receptor functions

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Importin 13 regulates nuclear import of the glucocorticoid receptor in airway epithelial cells

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Importin 7 and importin alpha/importin beta are nuclear import receptors for the glucocorticoid receptor

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Systemic glucocorticoid reduces bronchial mucosal activation of activator protein 1 components in glucocorticoid-sensitive but not glucocorticoid-resistant asthmatic patients

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Effect of low-dose theophylline plus beclometasone on lung function in smokers with asthma: a pilot study

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Emerging pharmacotherapies for COPD.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Ser/Thr protein phosphatase type 5 (PP5) is a negative regulator of glucocorticoid receptor-mediated growth arrest

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Phosphoinositide 3-kinase signalling in lung disease: leucocytes and beyond.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Phosphoinositide 3-kinase gamma required for lipopolysaccharide-induced transepithelial neutrophil trafficking in the lung

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Therapeutic potential of phosphoinositide 3-kinase inhibitors.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

The pharmacology of two novel long-acting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6-trimethylphenylimino)-3-(n-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6-diis

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

p38alpha-selective mitogen-activated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

An oral inhibitor of p38 MAP kinase reduces plasma fibrinogen in patients with chronic obstructive pulmonary disease.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

p38 mitogen-activated protein kinase pathways in asthma and COPD.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

IkappaB kinase-2-independent and -dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Inhibition of tumor necrosis factor-alpha-inducible inflammatory genes by interferon-gamma is associated with altered nuclear factor-kappaB transactivation and enhanced histone deacetylase activity.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Chemokine receptors as therapeutic targets in chronic obstructive pulmonary disease.

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Tocilizumab: blockade of interleukin-6 signaling pathway as a therapeutic strategy for inflammatory disorders

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Airway mucosal inflammation in COPD is similar in smokers and ex-smokers: a pooled analysis

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Prevention of Death in COPD

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Assessing and treating small airways disease in asthma and chronic obstructive pulmonary disease

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Validation of the Anti-Inflammatory Properties of Small-Molecule I B Kinase (IKK)-2 Inhibitors by Comparison with Adenoviral-Mediated Delivery of Dominant-Negative IKK1 and IKK2 in Human Airways Smooth Muscle

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Effect of 1-Year Treatment with Roflumilast in Severe Chronic Obstructive Pulmonary Disease

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Increased activation of p38 MAPK in COPD

1 reference

https://api.crossref.org/works/10.2165%2F11634350-000000000-00000

21 January 2018

Pathogenesis of COPD. Part I. The role of protease-antiprotease imbalance in emphysema

1 reference

https://pubmed.ncbi.nlm.nih.gov/22731962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined corticosteroid and long-acting beta-agonist in one inhaler versus placebo for chronic obstructive pulmonary disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22731962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CXCR3 and CCR5 Chemokines in Induced Sputum From Patients With COPD

1 reference

https://pubmed.ncbi.nlm.nih.gov/22731962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of High Dose Inhaled Steroid on Cells, Cytokines, and Proteases in Induced Sputum in Chronic Obstructive Pulmonary Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22731962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I

1 reference

https://pubmed.ncbi.nlm.nih.gov/22731962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/22731962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated T-lymphocytes and macrophages in bronchial mucosa of subjects with chronic bronchitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22731962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological Modulation of Th17

1 reference

https://pubmed.ncbi.nlm.nih.gov/22731962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of smoking on airway inflammation and remodelling in asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22731962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD

1 reference

https://pubmed.ncbi.nlm.nih.gov/22731962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of long-term treatment with corticosteroids in COPD

1 reference

https://pubmed.ncbi.nlm.nih.gov/22731962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphodiesterase-4: selective and dual-specificity inhibitors for the therapy of chronic obstructive pulmonary disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22731962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhaled corticosteroids in COPD: the case against

1 reference

https://pubmed.ncbi.nlm.nih.gov/22731962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New therapies for chronic obstructive pulmonary disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22731962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased content of thiobarbituric acid-reactive substances and hydrogen peroxide in the expired breath condensate of patients with stable chronic obstructive pulmonary disease: no significant effect of cigarette smoking

1 reference

https://pubmed.ncbi.nlm.nih.gov/22731962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhaled corticosteroids are not beneficial in chronic obstructive pulmonary disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22731962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Allen & Hanburys Limited UK Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/22731962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhaled corticosteroids for stable chronic obstructive pulmonary disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22731962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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