(Q38051447)

English

Intestinal transporters for endogenic and pharmaceutical organic anions: the challenges of deriving in-vitro kinetic parameters for the prediction of clinically relevant drug-drug interactions

scientific article published on 30 March 2012

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scholarly article

1 reference

Europe PubMed Central

27 August 2017

Intestinal transporters for endogenic and pharmaceutical organic anions: the challenges of deriving in-vitro kinetic parameters for the prediction of clinically relevant drug-drug interactions (English)

1 reference

Europe PubMed Central

27 August 2017

drug interaction

0 references

author name string

Anne Sophie Grandvuinet

1

1 reference

Europe PubMed Central

27 August 2017

Henrik Tang Vestergaard

2

1 reference

Europe PubMed Central

27 August 2017

Nicolas Rapin

3

1 reference

Europe PubMed Central

27 August 2017

Bente Steffansen

4

1 reference

Europe PubMed Central

27 August 2017

publication date

30 March 2012

1 reference

Europe PubMed Central

27 August 2017

Journal of Pharmacy and Pharmacology

1 reference

Europe PubMed Central

27 August 2017

64

1 reference

Europe PubMed Central

27 August 2017

1523-1548

1 reference

Europe PubMed Central

27 August 2017

11

1 reference

Europe PubMed Central

27 August 2017

Importance of P-glycoprotein for drug-drug interactions

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Drug-drug interactions affected by the transporter protein, P-glycoprotein (ABCB1, MDR1) II. Clinical aspects

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Membrane transporters in drug development

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Intestinal drug transporters: in vivo function and clinical importance.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Role of OATP transporters in the disposition of drugs

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Adaptive regulation of the ileal apical sodium dependent bile acid transporter (ASBT) in patients with obstructive cholestasis

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Distribution of breast cancer resistance protein (BCRP/ABCG2) mRNA expression along the human GI tract

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: comparison between human segments and Caco-2 cells.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Intestinal drug transporter expression and the impact of grapefruit juice in humans

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Breast cancer resistance protein (ABCG2) and drug disposition: intestinal expression, polymorphisms and sulfasalazine as an in vivo probe

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Expression and membrane localization of MCT isoforms along the length of the human intestine

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Gene and protein expression of P-glycoprotein, MRP1, MRP2, and CYP3A4 in the small and large human intestine.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Differential multidrug resistance-associated protein 1 through 6 isoform expression and function in human intestinal epithelial Caco-2 cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Tissue distribution and induction of human multidrug resistant protein 3

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Model analysis of the concentration-dependent permeability of P-gp substrates

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Mapping of multidrug resistance gene 1 and multidrug resistance-associated protein isoform 1 to 5 mRNA expression along the human intestinal tract

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Analysis of ABCC6 (MRP6) in normal human tissues.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in Human

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Vectorial transport of fexofenadine across Caco-2 cells: involvement of apical uptake and basolateral efflux transporters

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Transporter-Enzyme Interactions: Implications for Predicting Drug-Drug Interactions from In Vitro Data

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Enterohepatic circulation: physiological, pharmacokinetic and clinical implications

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Role of the intestinal bile acid transporters in bile acid and drug disposition

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Bile acid interactions with cholangiocytes

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Xenobiotic, bile acid, and cholesterol transporters: function and regulation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Development of stably transfected monolayer overexpressing the human apical sodium-dependent bile acid transporter (hASBT).

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Computational models for drug inhibition of the human apical sodium-dependent bile acid transporter

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

ABCG2 transports sulfated conjugates of steroids and xenobiotics

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Human breast cancer resistance protein: interactions with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and transport of cimetidine.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Transport of anthelmintic benzimidazole drugs by breast cancer resistance protein (BCRP/ABCG2).

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Protease inhibitors atazanavir, lopinavir and ritonavir are potent blockers, but poor substrates, of ABC transporters in a broad panel of ABC transporter-overexpressing cell lines

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Breast cancer resistance protein exports sulfated estrogens but not free estrogens

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

High-activity p-glycoprotein, multidrug resistance protein 2, and breast cancer resistance protein membrane vesicles prepared from transiently transfected human embryonic kidney 293-epstein-barr virus nuclear antigen cells.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

The calcium channel blockers, 1,4-dihydropyridines, are substrates of the multidrug resistance-linked ABC drug transporter, ABCG2.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance linked ATP binding cassette drug transporter ABCG2

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Breast cancer resistance protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

BCRP transports dipyridamole and is inhibited by calcium channel blockers

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Transport of glyburide by placental ABC transporters: implications in fetal drug exposure.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Leflunomide and its metabolite A771726 are high affinity substrates of BCRP: implications for drug resistance

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Involvement of breast cancer resistance protein (ABCG2) in the biliary excretion mechanism of fluoroquinolones.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

The effect of ABCG2 V12M, Q141K and Q126X, known functional variants in vitro, on the disposition of lamivudine

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

ATP-dependent transport of rosuvastatin in membrane vesicles expressing breast cancer resistance protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Transport and uptake of nateglinide in Caco-2 cells and its inhibitory effect on human monocarboxylate transporter MCT1.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Inhibitory effects of statins on human monocarboxylate transporter 4.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Competitive inhibition by genistein and ATP dependence of daunorubicin transport in intact MRP overexpressing human small cell lung cancer cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4).

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Direct evidence that saquinavir is transported by multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporter (MRP2).

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2).

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Investigation of the inhibitory effects of various drugs on the hepatic uptake of fexofenadine in humans

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa?

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Directional trans-epithelial transport of organic anions in porcine LLC-PK1 cells that co-express human OATP1B1 (OATP-C) and MRP2.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

OATP1B1, OATP1B3, and mrp2 are involved in hepatobiliary transport of olmesartan, a novel angiotensin II blocker

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2)

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of multidrug resistance protein 3.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Cellular entry of thyroid hormones by organic anion transporting polypeptides

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Topotecan is a substrate for multidrug resistance associated protein 4.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6).

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Identification of influx transporter for the quinolone antibacterial agent levofloxacin

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Multispecific amphipathic substrate transport by an organic anion transporter of human liver.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Interaction of imatinib with human organic ion carriers

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Intestinal absorption mechanism of tebipenem pivoxil, a novel oral carbapenem: involvement of human OATP family in apical membrane transport

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Identification of steroid sulfate transport processes in the human mammary gland

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Modification of OATP2B1-mediated transport by steroid hormones

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Pharmacokinetics of the oral direct renin inhibitor aliskiren in combination with digoxin, atorvastatin, and ketoconazole in healthy subjects: the role of P-glycoprotein in the disposition of aliskiren

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Drug-drug interaction between pitavastatin and various drugs via OATP1B1.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

pH dependence of organic anion-transporting polypeptide 2B1 in Caco-2 cells: potential role in antiretroviral drug oral bioavailability and drug-drug interactions

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Molecular characterization of human and rat organic anion transporter OATP-D

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Functional Complementation between a Novel Mammalian Polygenic Transport Complex and an Evolutionarily Ancient Organic Solute Transporter, OSTα-OSTβ

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

A multidrug resistance transporter from human MCF-7 breast cancer cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Breast cancer resistance protein in pharmacokinetics and drug-drug interactions

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

In vitro and in vivo evidence for the importance of breast cancer resistance protein transporters (BCRP/MXR/ABCP/ABCG2).

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Impact of OATP transporters on pharmacokinetics

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Prediction of human pharmacokinetics-biliary and intestinal clearance and enterohepatic circulation

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Intestinal permeability and its relevance for absorption and elimination

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Development, validation and utility of an in vitro technique for assessment of potential clinical drug-drug interactions involving P-glycoprotein

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

P-gp inhibition potential in cell-based models: which "calculation" method is the most accurate?

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Decrease in intracellular concentration causes the shift in Km value of efflux pump substrates.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Estimation of Michaelis-Menten constant of efflux transporter considering asymmetric permeability

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Refining the in vitro and in vivo critical parameters for P-glycoprotein, [I]/IC50 and [I2]/IC50, that allow for the exclusion of drug candidates from clinical digoxin interaction studies

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Establishment of in vitro P-glycoprotein inhibition assay and its exclusion criteria to assess the risk of drug-drug interaction at the drug discovery stage.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Predicting drug-drug interactions involving the inhibition of intestinal CYP3A4 and P-glycoprotein

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Effect of P-glycoprotein expression levels on the concentration-dependent permeability of drugs to the cell membrane

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Permeability, transport, and metabolism of solutes in Caco-2 cell monolayers: a theoretical study.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

The steady-state Michaelis-Menten analysis of P-glycoprotein mediated transport through a confluent cell monolayer cannot predict the correct Michaelis constant Km.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

The elementary mass action rate constants of P-gp transport for a confluent monolayer of MDCKII-hMDR1 cells.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Flux measurements across Caco-2 monolayers may predict transport in human large intestinal tissue

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Coexistence of passive and carrier-mediated processes in drug transport

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Impact of carriers in oral absorption: Permeation across Caco-2 cells for the organic anions estrone-3-sulfate and glipizide.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Interactions between organic anions on multiple transporters in Caco-2 cells.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Knocking down transport: applications of RNA interference in the study of drug transport proteins

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

siRNA--getting the message out.

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

The ABCG2 transporter and its relations with the pharmacokinetics, drug interaction and lipid-lowering effects of statins

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Drug-drug interactions mediated through P-glycoprotein: clinical relevance and in vitro-in vivo correlation using digoxin as a probe drug

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studies

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

The "high solubility" definition of the current FDA Guidance on Biopharmaceutical Classification System may be too strict for acidic drugs

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

The role of transporters in the pharmacokinetics of orally administered drugs

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2012.01505.X

21 January 2018

Identifiers

10.1111/J.2042-7158.2012.01505.X

1 reference

Europe PubMed Central

27 August 2017

1 reference

Europe PubMed Central

27 August 2017

ResearchGate publication ID

0 references

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