(Q38056099)

27 August 2017

The emerging role of Polycomb repressors in the response to DNA damage (English)

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27 August 2017

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Joseph H A Vissers

1

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27 August 2017

Maarten van Lohuizen

series ordinal

2

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27 August 2017

Elisabetta Citterio

series ordinal

3

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27 August 2017

language of work or name

English

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publication date

1 September 2012

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27 August 2017

Journal of Cell Science

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27 August 2017

125

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27 August 2017

3939-3948

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27 August 2017

Pt 17

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The ubiquitous role of ubiquitin in the DNA damage response

27 August 2017

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Determinants and dynamics of genome accessibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Molecular control of pluripotency

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Polycomb group proteins: navigators of lineage pathways led astray in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

An anticlastogenic function for the Polycomb Group gene Bmi1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

The DNA Damage Response: Making It Safe to Play with Knives

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Cellular functions of the DUBs

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

DNA damage, homology-directed repair, and DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Multiple roles of ATM in monitoring and maintaining DNA integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

53BP1 facilitates long-range DNA end-joining during V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Activation of multiple DNA repair pathways by sub-nuclear damage induction methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

A phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Polycomb group proteins in the DNA damage response: a link between radiation resistance and "stemness".

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

The role of the histone H2A ubiquitinase Sce in Polycomb repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Coping with DNA double strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

DNA Damage, Aging, and Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

The polycomb protein Pc2 is a SUMO E3

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Modification of proteins by ubiquitin and ubiquitin-like proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Breaking the chains: structure and function of the deubiquitinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Bmi1 regulates mitochondrial function and the DNA damage response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Tumor suppression by Ink4a-Arf: progress and puzzles

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Close encounters of the RNF8th kind: when chromatin meets DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

The Polycomb complex PRC2 and its mark in life

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

An improved zinc-finger nuclease architecture for highly specific genome editing

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Brca1 controls homology-directed DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Histone methyltransferase activity of a Drosophila Polycomb group repressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

DNA repair: easy to visualize, difficult to elucidate

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

ATR signalling: more than meeting at the fork

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Genomic instability--an evolving hallmark of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Human USP3 is a chromatin modifier required for S phase progression and genome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Monoubiquitination of H2AX protein regulates DNA damage response signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

DNAPKcs-dependent arrest of RNA polymerase II transcription in the presence of DNA breaks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

The polycomb group protein Suz12 is required for embryonic stem cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Ubiquitin: structures, functions, mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Stem cell regulation by polycomb repressors: postponing commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Double-strand break-induced transcriptional silencing is associated with loss of tri-methylation at H3K4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Neighborly DISCourse: DNA double strand breaks silence transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Mechanisms of polycomb gene silencing: knowns and unknowns

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Polycomb silencers control cell fate, development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Signals and combinatorial functions of histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Polycomb group proteins set the stage for early lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Connecting the Dots: Interplay between Ubiquitylation and SUMOylation at DNA Double-Strand Breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Ubiquitin and SUMO in DNA repair at a glance

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

The many faces of ubiquitinated histone H2A: insights from the DUBs

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Role of histone H2A ubiquitination in Polycomb silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

The mechanism of OTUB1-mediated inhibition of ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Critical role of monoubiquitination of histone H2AX protein in histone H2AX phosphorylation and DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Histone ubiquitination associates with BRCA1-dependent DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Polycomb protein EZH2 regulates cancer cell fate decision in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

DNA double-strand break repair: all's well that ends well

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1242%2FJCS.107375

21 January 2018

Identifiers

DOI

10.1242/JCS.107375

1 reference

27 August 2017

1 reference