(Q38059777)

28 August 2017

How cancer metabolism is tuned for proliferation and vulnerable to disruption (English)

1 reference

PubMed ID

23151579

Erratum: Corrigendum: How cancer metabolism is tuned for proliferation and vulnerable to disruption

28 August 2017

corrigendum / erratum

1 reference

12 July 2019

http://api.crossref.org/works?select=update-to&filter=doi:10.1038/NATURE11827

author

Adrian Harris

series ordinal

2

1 reference

28 August 2017

Almut Schulze

1

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language of work or name

English

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publication date

1 November 2012

1 reference

28 August 2017

1 reference

28 August 2017

491

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28 August 2017

364-373

1 reference

28 August 2017

7424

1 reference

https://scigraph.springernature.com/pub.10.1038/nature11706

28 August 2017

0 references

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

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Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models

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Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

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12 December 2020

Why do cancers have high aerobic glycolysis?

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12 December 2020

Dysregulation of the mevalonate pathway promotes transformation

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Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

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Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

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IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

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Lack of effect of lowering LDL cholesterol on cancer: meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy

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Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

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CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

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Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review

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An integrated genomic analysis of human glioblastoma multiforme

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Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

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12 December 2020

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

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12 December 2020

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

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12 December 2020

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

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12 December 2020

Global reconstruction of the human metabolic network based on genomic and bibliomic data

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12 December 2020

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

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12 December 2020

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence

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12 December 2020

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

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Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

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Targeting cancer metabolism: a therapeutic window opens

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

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Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas

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Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo

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Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

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Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

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Recurring mutations found by sequencing an acute myeloid leukemia genome

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12 December 2020

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

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12 December 2020

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

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12 December 2020

Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target

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12 December 2020

Lipid metabolism in cancer

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12 December 2020

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

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12 December 2020

Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation.

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12 December 2020

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

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12 December 2020

Histone deacetylase inhibition increases levels of choline kinase α and phosphocholine facilitating noninvasive imaging in human cancers

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12 December 2020

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

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12 December 2020

Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

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12 December 2020

Pyruvate kinase M2 is a phosphotyrosine-binding protein

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12 December 2020

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

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12 December 2020

The monocarboxylate transporter family--role and regulation

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12 December 2020

ATP-citrate lyase links cellular metabolism to histone acetylation

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12 December 2020

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

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12 December 2020

C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight

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12 December 2020

Hypoxia, HIF1 and glucose metabolism in the solid tumour

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12 December 2020

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.

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12 December 2020

IDH1 and IDH2 mutations in gliomas

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12 December 2020

Reductive carboxylation supports growth in tumour cells with defective mitochondria.

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12 December 2020

Mitochondrial reactive oxygen species regulate hypoxic signaling

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12 December 2020

FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression

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12 December 2020

Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells

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12 December 2020

13C MRS studies of neuroenergetics and neurotransmitter cycling in humans

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12 December 2020

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

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12 December 2020

Mitochondrial tumour suppressors: a genetic and biochemical update

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12 December 2020

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

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12 December 2020

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

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12 December 2020

SnapShot: Tumor angiogenesis

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12 December 2020

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

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12 December 2020

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

1 reference

12 December 2020

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

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12 December 2020

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

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12 December 2020

IDH mutation impairs histone demethylation and results in a block to cell differentiation

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12 December 2020

Understanding the Warburg effect: the metabolic requirements of cell proliferation

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12 December 2020

Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival.

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12 December 2020

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

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12 December 2020

Metabolic modulation of glioblastoma with dichloroacetate

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12 December 2020

p53 regulates mitochondrial respiration

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12 December 2020

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

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12 December 2020

Aerobic glycolysis: meeting the metabolic requirements of cell proliferation

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12 December 2020

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

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12 December 2020

Normal and cancer cell metabolism: lymphocytes and lymphoma.

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12 December 2020

Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2.

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12 December 2020

Deregulated MYC expression induces dependence upon AMPK-related kinase 5.

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12 December 2020

New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation

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12 December 2020

Predicting selective drug targets in cancer through metabolic networks.

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12 December 2020

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

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12 December 2020

Current and potential applications of clinical 13C MR spectroscopy

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12 December 2020

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

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12 December 2020

HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition

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12 December 2020

Targeting metabolic transformation for cancer therapy.

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12 December 2020

Identifiers

DOI

10.1038/NATURE11706

1 reference

PubMed ID

23151579

Dimensions Publication ID

28 August 2017

0 references

1 reference

PubMed ID

23151579