(Q38068912)

28 August 2017

1 reference

title

Species differences in drug transporters and implications for translating preclinical findings to humans (English)

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28 August 2017

Xiaoyan Chu

1

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28 August 2017

Kelly Bleasby

series ordinal

2

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28 August 2017

Raymond Evers

series ordinal

3

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28 August 2017

language of work or name

English

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publication date

21 December 2012

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Expert Opinion on Drug Metabolism & Toxicology

28 August 2017

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28 August 2017

9

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28 August 2017

237-252

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28 August 2017

3

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Membrane transporters in drug development

28 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

P-glycoprotein related drug interactions: clinical importance and a consideration of disease states

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Utility of Mdr1-gene deficient mice in assessing the impact of P-glycoprotein on pharmacokinetics and pharmacodynamics in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Liquid chromatography/tandem mass spectrometry based targeted proteomics quantification of P-glycoprotein in various biological samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Quantitative membrane protein expression at the blood-brain barrier of adult and younger cynomolgus monkeys.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Establishment and characterization of the transformants stably-expressing MDR1 derived from various animal species in LLC-PK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Kinetic analyses for species differences in P-glycoprotein-mediated drug transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Drug interactions at the blood-brain barrier: fact or fantasy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Species differences of inhibitory effects on P-glycoprotein-mediated drug transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Pgp-mediated interaction between (R)-[11C]verapamil and tariquidar at the human blood-brain barrier: a comparison with rat data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Verapamil P-glycoprotein transport across the rat blood-brain barrier: cyclosporine, a concentration inhibition analysis, and comparison with human data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

P-glycoprotein-based loperamide-cyclosporine drug interaction at the rat blood-brain barrier: prediction from in vitro studies and extrapolation to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

In vitro and in vivo evidence for the importance of breast cancer resistance protein transporters (BCRP/MXR/ABCP/ABCG2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Distribution of breast cancer resistance protein (BCRP/ABCG2) mRNA expression along the human GI tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Expression profiles of metabolic enzymes and drug transporters in the liver and along the intestine of beagle dogs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

21 January 2018

ABCG2: a perspective.

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

The challenge of exploiting ABCG2 in the clinic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Identification of interspecies difference in hepatobiliary transporters to improve extrapolation of human biliary secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

LC-MS/MS mediated absolute quantification and comparison of bile salt export pump and breast cancer resistance protein in livers and hepatocytes across species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Sex-dependent expression and activity of the ATP-binding cassette transporter breast cancer resistance protein (BCRP/ABCG2) in liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Physiological and pharmacological roles of ABCG2 (BCRP): recent findings in Abcg2 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Investigation of efflux transport of dehydroepiandrosterone sulfate and mitoxantrone at the mouse blood-brain barrier: a minor role of breast cancer resistance protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of phytoestrogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Quantitative investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) in limiting brain and testis penetration of xenobiotic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Relationship between drug/metabolite exposure and impairment of excretory transport function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

A family of drug transporters: the multidrug resistance-associated proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Functional analysis of mouse and monkey multidrug resistance-associated protein 2 (Mrp2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Species-dependent transport and modulation properties of human and mouse multidrug resistance protein 2 (MRP2/Mrp2, ABCC2/Abcc2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

On the putative co-transport of drugs by multidrug resistance proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Absolute difference of hepatobiliary transporter multidrug resistance-associated protein (MRP2/Mrp2) in liver tissues and isolated hepatocytes from rat, dog, monkey, and human.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Interindividual variability in hepatic expression of the multidrug resistance-associated protein 2 (MRP2/ABCC2): quantification by liquid chromatography/tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Characterization of mice lacking the multidrug resistance protein MRP2 (ABCC2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Plasma membrane localization of multidrug resistance-associated protein homologs in brain capillary endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

MRP2 and 3 in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Multidrug resistance-associated proteins 3, 4, and 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Up-regulation of Mrp4 expression in kidney of Mrp2-deficient TR- rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimethamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Characterization of the human MATE2 proton-coupled polyspecific organic cation exporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Physiological and pharmacokinetic roles of H+/organic cation antiporters (MATE/SLC47A).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Uptake transporters of the human OATP family: molecular characteristics, substrates, their role in drug-drug interactions, and functional consequences of polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Role of OATP transporters in the disposition of drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Cloning/characterization of the canine organic anion transporting polypeptide 1b4 (Oatp1b4) and classification of the canine OATP/SLCO members

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Role of the murine organic anion-transporting polypeptide 1b2 (Oatp1b2) in drug disposition and hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Functions of OATP1A and 1B transporters in vivo: insights from mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Prediction of pharmacokinetic profile of valsartan in human based on in vitro uptake transport data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Simultaneous assessment of uptake and metabolism in rat hepatocytes: a comprehensive mechanistic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Human renal organic anion transporter 4 operates as an asymmetric urate transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Role of organic cation transporters in drug-induced toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Gene expression and regulation of drug transporters in the intestine and kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Cellular localization of the organic cation transporters, OCT1 and OCT2, in brain microvessel endothelial cells and its implication for MPTP transport across the blood-brain barrier and MPTP-induced dopaminergic toxicity in rodents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Involvement of Mrp2/MRP2 in the species different excretion route of benzylpenicillin between rat and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Xenobiotic transporters: ascribing function from gene knockout and mutation studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Characterization of multidrug resistance 1a/P-glycoprotein knockout rats generated by zinc finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Physiologically-based pharmacokinetics in drug development and regulatory science

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.741589

10.1517/17425255.2013.741589

21 January 2018

Identifiers

DOI

1 reference

28 August 2017

1 reference