(Q38077051)

28 August 2017

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title

The eIF2α kinases: their structures and functions (English)

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28 August 2017

Adrienne M Gorman

2

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Afshin Samali

object named as

Afshin Samali

series ordinal

4

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author name string

Neysan Donnelly

series ordinal

1

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PubMed ID

23354059

28 August 2017

Sanjeev Gupta

series ordinal

3

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28 August 2017

26 January 2013

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Cellular and Molecular Life Sciences

28 August 2017

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28 August 2017

70

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28 August 2017

3493-3511

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28 August 2017

19

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https://scigraph.springernature.com/pub.10.1007/s00018-012-1252-6

28 August 2017

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cites work

Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection

1 reference

12 December 2020

IRE1 signaling affects cell fate during the unfolded protein response

1 reference

12 December 2020

Inactivation of the PKR protein kinase and stimulation of mRNA translation by the cellular co-chaperone P58(IPK) does not require J domain function

1 reference

12 December 2020

Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses

1 reference

12 December 2020

ER stress, hypoxia tolerance and tumor progression.

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12 December 2020

Stress-induced gene expression requires programmed recovery from translational repression

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12 December 2020

PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control

1 reference

12 December 2020

Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition

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12 December 2020

Oxidative folding: cellular strategies for dealing with the resultant equimolar production of reactive oxygen species

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12 December 2020

Haem-regulated eIF2alpha kinase is necessary for adaptive gene expression in erythroid precursors under the stress of iron deficiency.

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12 December 2020

Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAX.

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12 December 2020

Dual function of pancreatic endoplasmic reticulum kinase in tumor cell growth arrest and survival.

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12 December 2020

Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway

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12 December 2020

PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha

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12 December 2020

PKR-dependent CHOP induction limits hyperoxia-induced lung injury.

1 reference

12 December 2020

Functional expression and characterization of the interferon-induced double-stranded RNA activated P68 protein kinase from Escherichia coli

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12 December 2020

C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene

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12 December 2020

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase

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12 December 2020

Snf1 promotes phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 by activating Gcn2 and inhibiting phosphatases Glc7 and Sit4.

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12 December 2020

PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53

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12 December 2020

Melanoma differentiation-associated gene-7 protein physically associates with the double-stranded RNA-activated protein kinase PKR.

1 reference

12 December 2020

Modular structure of PACT: distinct domains for binding and activating PKR

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12 December 2020

RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules

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12 December 2020

Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway

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12 December 2020

Mediators of endoplasmic reticulum stress-induced apoptosis

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12 December 2020

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

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12 December 2020

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

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12 December 2020

Ero1 and redox homeostasis in the endoplasmic reticulum.

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12 December 2020

The structure of the PERK kinase domain suggests the mechanism for its activation

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12 December 2020

Heterologous dimerization domains functionally substitute for the double-stranded RNA binding domains of the kinase PKR.

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12 December 2020

Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.

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12 December 2020

Targeting the endoplasmic reticulum-stress response as an anticancer strategy

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12 December 2020

A model for the double-stranded RNA (dsRNA)-dependent dimerization and activation of the dsRNA-activated protein kinase PKR.

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12 December 2020

Translational control in stress and apoptosis

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12 December 2020

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

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12 December 2020

Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.

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12 December 2020

Multiple autophosphorylation is essential for the formation of the active and stable homodimer of heme-regulated eIF2alpha kinase

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12 December 2020

The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR

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12 December 2020

NF-kappaB and cancer-identifying targets and mechanisms

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12 December 2020

Stress-induced phosphorylation of PACT reduces its interaction with TRBP and leads to PKR activation

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12 December 2020

Inhibition of PKR by RNA and DNA viruses

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12 December 2020

Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR

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12 December 2020

Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions

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12 December 2020

Essential role of PACT-mediated PKR activation in tunicamycin-induced apoptosis

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12 December 2020

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

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12 December 2020

Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.

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12 December 2020

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

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12 December 2020

Stress hypERactivation in the β-cell

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12 December 2020

PKR-like endoplasmic reticulum kinase (PERK) activation following brain ischemia is independent of unfolded nascent proteins

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12 December 2020

The Gcn2 kinase as a cell cycle regulator

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12 December 2020

Amino Acid Limitation Induces Expression ofCHOP, a CCAAT/Enhancer Binding Protein-related Gene, at Both Transcriptional and Post-transcriptional Levels

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12 December 2020

Activation of PKR: an open and shut case?

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12 December 2020

The double-strand RNA-dependent protein kinase PKR plays a significant role in a sustained ER stress-induced apoptosis

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12 December 2020

TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death

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12 December 2020

The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores

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12 December 2020

Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone

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12 December 2020

Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis

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12 December 2020

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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12 December 2020

The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid.

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12 December 2020

The eIF2alpha kinases inhibit vesicular stomatitis virus replication independently of eIF2alpha phosphorylation

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12 December 2020

Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis

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12 December 2020

Roles of CHOP/GADD153 in endoplasmic reticulum stress

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12 December 2020

Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR

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12 December 2020

The mechanism of eukaryotic translation initiation and principles of its regulation

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12 December 2020

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

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12 December 2020

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

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12 December 2020

Regulated translation initiation controls stress-induced gene expression in mammalian cells

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12 December 2020

Translation initiation control by heme-regulated eukaryotic initiation factor 2alpha kinase in erythroid cells under cytoplasmic stresses

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12 December 2020

Domain stabilities in protein kinase R (PKR): evidence for weak interdomain interactions

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12 December 2020

Regulation of autophagy by ATF4 in response to severe hypoxia.

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12 December 2020

A global map of p53 transcription-factor binding sites in the human genome

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12 December 2020

Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency

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12 December 2020

Involvement of Double-stranded RNA-activated Protein Kinase in the Synergistic Activation of Nuclear Factor-κB by Tumor Necrosis Factor-α and γ-Interferon in Preneuronal Cells

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12 December 2020

PKR is not a universal target of tumor suppressor p53 in response to genotoxic stress

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12 December 2020

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

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12 December 2020

Kinetic studies on the successive reaction of neuronal nitric oxide synthase from L-arginine to nitric oxide and L-citrulline

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12 December 2020

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

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12 December 2020

The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53.

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12 December 2020

Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition

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12 December 2020

Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase

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12 December 2020

Divergent effects of PERK and IRE1 signaling on cell viability

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12 December 2020

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

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12 December 2020

Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress

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12 December 2020

An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease

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12 December 2020

5' untranslated sequences are required for the translational control of a yeast regulatory gene

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12 December 2020

Unactivated PKR exists in an open conformation capable of binding nucleotides

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12 December 2020

Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.

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12 December 2020

Analysis of PKR structure by small-angle scattering

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12 December 2020

Activators and target genes of Rel/NF-kappaB transcription factors

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12 December 2020

Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53

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12 December 2020

Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest

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12 December 2020

Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses

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12 December 2020

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.

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12 December 2020

The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress

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12 December 2020

Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response

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12 December 2020

PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.

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12 December 2020

Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs

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12 December 2020

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

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12 December 2020

Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation

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12 December 2020

PACT and PKR: turning on NF-kappa B in the absence of virus

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12 December 2020

Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells

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12 December 2020

Phosphorylation of eIF2alpha in response to 26S proteasome inhibition is mediated by the haem-regulated inhibitor (HRI) kinase.

1 reference

12 December 2020

Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: a consequence of endoplasmic reticulum (ER) stress induction, activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2alpha (eIF2alpha)-kinase

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12 December 2020

Functional characterization of Drosophila melanogaster PERK eukaryotic initiation factor 2alpha (eIF2alpha) kinase.

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12 December 2020

Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR.

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12 December 2020

Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization

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12 December 2020

Requirement for kinase-induced conformational change in eukaryotic initiation factor 2alpha (eIF2alpha) restricts phosphorylation of Ser51.

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12 December 2020

Two heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertion

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12 December 2020

Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation

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12 December 2020

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

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12 December 2020

Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice

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12 December 2020

Upstream open reading frames: molecular switches in (patho)physiology

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12 December 2020

Mechanisms of ferriheme reduction by nitric oxide: nitrite and general base catalysis

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12 December 2020

Homologous regions of the alpha subunit of eukaryotic translational initiation factor 2 (eIF2alpha) and the vaccinia virus K3L gene product interact with the same domain within the dsRNA-activated protein kinase (PKR)

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12 December 2020

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity

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12 December 2020

Translational regulation of GCN4 and the general amino acid control of yeast

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12 December 2020

Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2

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12 December 2020

Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR

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12 December 2020

An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells

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12 December 2020

Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKR

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12 December 2020

Thalassemia: pathophysiology of red cell changes

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12 December 2020

PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway

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12 December 2020

PI(3)king apart PTEN's role in cancer.

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12 December 2020

Impaired dexamethasone-mediated induction of tryptophan 2,3-dioxygenase in heme-deficient rat hepatocytes: translational control by a hepatic eIF2alpha kinase, the heme-regulated inhibitor

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12 December 2020

Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI

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12 December 2020

Central Role of Double-Stranded RNA-Activated Protein Kinase in Microbial Induction of Nitric Oxide Synthase

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12 December 2020

Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways.

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12 December 2020

Double-stranded RNA-activated protein kinase is required for the LPS-induced activation of STAT1 inflammatory signaling in rat brain glial cells

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12 December 2020

EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

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12 December 2020

Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB.

1 reference

12 December 2020

The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus.

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12 December 2020

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells

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12 December 2020

Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity

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12 December 2020

PACT, a stress-modulated cellular activator of interferon-induced double-stranded RNA-activated protein kinase, PKR.

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12 December 2020

Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway

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12 December 2020

Mutations in the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2 alpha) that overcome the inhibitory effect of eIF-2 alpha phosphorylation on translation initiation

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12 December 2020

Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase

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12 December 2020

Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways

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12 December 2020

PKR; a sentinel kinase for cellular stress

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12 December 2020

Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK.

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12 December 2020

Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2.

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12 December 2020

Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target

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12 December 2020

Nrf2 signaling and cell survival

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12 December 2020

Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR

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12 December 2020

The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin

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12 December 2020

Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase

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12 December 2020

Role of protein kinase R in double-stranded RNA-induced expression of nitric oxide synthase in human astroglia

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12 December 2020

Activating transcription factor 4.

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12 December 2020

Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2).

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12 December 2020

ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice

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12 December 2020

RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling

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12 December 2020

Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR).

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12 December 2020

Inhibition of the double-stranded RNA-dependent protein kinase PKR by mammalian ribosomes

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12 December 2020

Eukaryotic translation initiation factors and regulators

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12 December 2020

An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation

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12 December 2020

Intrinsic capacities of molecular sensors of the unfolded protein response to sense alternate forms of endoplasmic reticulum stress

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12 December 2020

Erythroid expression of the heme-regulated eIF-2 alpha kinase

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12 December 2020

The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation

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12 December 2020

A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR.

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12 December 2020

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

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12 December 2020

Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.

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12 December 2020

Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.

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12 December 2020

PERK mediates cell-cycle exit during the mammalian unfolded protein response

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12 December 2020

The dsRNA protein kinase PKR: virus and cell control

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12 December 2020

UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4/CHOP stimulation of TRB3 expression.

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12 December 2020

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice

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12 December 2020

S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration

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12 December 2020

PERK in beta cell biology and insulin biogenesis

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12 December 2020

ER stress triggers apoptosis by activating BH3-only protein Bim

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12 December 2020

Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis.

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12 December 2020

eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver

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12 December 2020

A synthetic peptide substrate for initiation factor-2 kinases

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12 December 2020

The role of p58IPK in protecting the stressed endoplasmic reticulum

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12 December 2020

Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death

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12 December 2020

Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions

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12 December 2020

P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling

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12 December 2020

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

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12 December 2020

Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response

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12 December 2020

RNA dimerization promotes PKR dimerization and activation

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12 December 2020

Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions

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12 December 2020

Nutritional control of gene expression: how mammalian cells respond to amino acid limitation

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12 December 2020

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

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12 December 2020

PACT, a protein activator of the interferon-induced protein kinase, PKR.

1 reference

12 December 2020

The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

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12 December 2020

Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation

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12 December 2020

Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox

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12 December 2020

GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation

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12 December 2020

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

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12 December 2020

Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias

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12 December 2020

Perk is essential for translational regulation and cell survival during the unfolded protein response

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12 December 2020

PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway

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12 December 2020

IRE1α disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level

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12 December 2020

Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis

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12 December 2020

Activation of heme-regulated eukaryotic initiation factor 2alpha kinase by nitric oxide is induced by the formation of a five-coordinate NO-heme complex: optical absorption, electron spin resonance, and resonance raman spectral studies

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12 December 2020

Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies.

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12 December 2020

JNK2 and IKKbeta are required for activating the innate response to viral infection

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12 December 2020

Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis.

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12 December 2020

RNA granules: the good, the bad and the ugly

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12 December 2020

GCN2 whets the appetite for amino acids

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12 December 2020

CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells

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12 December 2020

Nitric oxide and endoplasmic reticulum stress

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12 December 2020

Nitric oxide: from a mysterious labile factor to the molecule of the Nobel Prize. Recent progress in nitric oxide research.

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12 December 2020

Viral control of mitochondrial apoptosis

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12 December 2020

Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control

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12 December 2020

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

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12 December 2020

Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cells

1 reference

12 December 2020

Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha.

1 reference

12 December 2020

Myxoma virus immunomodulatory protein M156R is a structural mimic of eukaryotic translation initiation factor eIF2alpha

1 reference

12 December 2020

Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication

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12 December 2020

Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response

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12 December 2020

The unfolded protein response signals through high-order assembly of Ire1

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12 December 2020

Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

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12 December 2020

Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation

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12 December 2020

Defects in translational regulation mediated by the alpha subunit of eukaryotic initiation factor 2 inhibit antiviral activity and facilitate the malignant transformation of human fibroblasts

1 reference

12 December 2020

Evidence for translational regulation of the activator of general amino acid control in yeast

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12 December 2020

Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia

1 reference

12 December 2020

10.1007/S00018-012-1252-6

Identifiers

DOI

1 reference

28 August 2017

1 reference

PubMed ID

23354059