(Q38165133)

30 August 2017

title

The multifaceted activities of AMPK in tumor progression--why the "one size fits all" definition does not fit at all? (English)

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30 August 2017

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Marcelo G Bonini

1

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30 August 2017

Benjamin N Gantner

series ordinal

2

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30 August 2017

publication date

1 November 2013

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30 August 2017

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30 August 2017

volume

65

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30 August 2017

issue

11

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30 August 2017

page(s)

889-896

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AMP-activated protein kinase: new regulation, new roles?

30 August 2017

cites work

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5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle

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Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism

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Activation of glycogen phosphorylase and glycogenolysis in rat skeletal muscle by AICAR--an activator of AMP-activated protein kinase

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Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway.

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AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release.

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AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

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Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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Diabetes, cancer, and metformin: connections of metabolism and cell proliferation

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The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin.

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Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

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AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells.

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AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators

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AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C.

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

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5'AMP-activated protein kinase alpha deficiency enhances stress-induced apoptosis in BHK and PC12 cells

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Survival advantage of AMPK activation to androgen-independent prostate cancer cells during energy stress

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Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy.

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Role of the alpha2-isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia.

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Inhibition of AMP-activated protein kinase α (AMPKα) by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts and cardiomyocytes: role of p53 and SIRT1.

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Activation of AMP-activated protein kinase alpha1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and survivin

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Survivin is an independent predictor of short-term survival in poor prognostic breast cancer patients

21 January 2018

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p53 and bcl-2 expression in high-grade B-cell lymphomas: correlation with survival time

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Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation

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The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis

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Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin

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Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

21 January 2018

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Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism

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Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.

21 January 2018

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Metformin activates AMP kinase through inhibition of AMP deaminase

21 January 2018

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AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

21 January 2018

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The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

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Cancer cell metabolism: Warburg and beyond

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The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

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The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis

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CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells

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AMPK and GCN2-ATF4 signal the repression of mitochondria in colon cancer cells.

21 January 2018

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The Akt-mTOR tango and its relevance to cancer

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AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3.

21 January 2018

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AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia

21 January 2018

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AMPK exerts dual regulatory effects on the PI3K pathway.

21 January 2018

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mTOR: from growth signal integration to cancer, diabetes and ageing

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IRS-1: auditing the effectiveness of mTOR inhibitors

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Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.

21 January 2018

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Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells

21 January 2018

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Metabolic reprogramming: a cancer hallmark even warburg did not anticipate

21 January 2018

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From single cells to deep phenotypes in cancer

21 January 2018

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Accessories to the crime: functions of cells recruited to the tumor microenvironment

21 January 2018

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Nuclear reprogramming to a pluripotent state by three approaches

21 January 2018

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A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts

21 January 2018

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AMP-activated protein kinase is required for induction of apoptosis and epithelial-to-mesenchymal transition

21 January 2018

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Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells

21 January 2018

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Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity.

21 January 2018

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NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

21 January 2018

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Nuclear reprogramming with c-Myc potentiates glycolytic capacity of derived induced pluripotent stem cells.

21 January 2018

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The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming

21 January 2018

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FM19G11 favors spinal cord injury regeneration and stem cell self-renewal by mitochondrial uncoupling and glucose metabolism induction

21 January 2018

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ARK5 is a tumor invasion-associated factor downstream of Akt signaling

21 January 2018

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Deregulated MYC expression induces dependence upon AMPK-related kinase 5.

21 January 2018

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mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: a roadmap from energy metabolism to stem cell renewal and aging

21 January 2018

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mTOR-STAT3-notch signalling contributes to ALDH2-induced protection against cardiac contractile dysfunction and autophagy under alcoholism

21 January 2018

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Wnt signaling activation in adipose progenitors promotes insulin-independent muscle glucose uptake

21 January 2018

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Coordinated time-dependent modulation of AMPK/Akt/mTOR signaling and autophagy controls osteogenic differentiation of human mesenchymal stem cells

21 January 2018

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AMP-activated Protein Kinase and the Regulation of Autophagic Proteolysis

21 January 2018

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5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase-Independent Effect on Glucokinase Translocation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IUB.1213

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30 August 2017

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