(Q38302052)

1 September 2017

title

The role of cytosolic phospholipase A2 α in amyloid precursor protein induction by amyloid beta1-42 : implication for neurodegeneration (English)

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1 September 2017

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Chen Sagy-Bross

1

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1 September 2017

Ksenia Kasianov

2

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1 September 2017

Yulia Solomonov

3

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1 September 2017

Alex Braiman

4

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1 September 2017

Alon Friedman

5

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Nurit Hadad

6

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1 September 2017

Rachel Levy

7

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1 September 2017

language of work or name

English

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publication date

1 December 2014

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Journal of Neurochemistry

1 September 2017

published in

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1 September 2017

volume

132

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1 September 2017

issue

5

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1 September 2017

page(s)

559-571

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Neurodegenerative diseases and oxidative stress

1 September 2017

cites work

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5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo

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Purification of a 110-kilodalton cytosolic phospholipase A2 from the human monocytic cell line U937.

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Reactive glia express cytosolic phospholipase A2 after transient global forebrain ischemia in the rat.

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In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease

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Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling

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Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation

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Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo

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Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration

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Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

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Critical role of cPLA2 in Aβ oligomer-induced neurodegeneration and memory deficit.

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Rodent models of Alzheimer's disease: rat A beta infusion approaches to amyloid deposits

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Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology

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Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules

21 January 2018

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Endothelial ICAM-1 protein induction is regulated by cytosolic phospholipase A2α via both NF-κB and CREB transcription factors

21 January 2018

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Induction of Fc gammaRIIA expression in myeloid PLB cells during differentiation depends on cytosolic phospholipase A2 activity and is regulated via activation of CREB by PGE2.

21 January 2018

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Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL

21 January 2018

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Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer disease

21 January 2018

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Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo

21 January 2018

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Neuron-derived D-serine release provides a novel means to activate N-methyl-D-aspartate receptors.

21 January 2018

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Expression of APP in the early stage of brain damage

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Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

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Assay and purification of phospholipase A2 from human synovial fluid in rheumatoid arthritis

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Neurodegenerative tauopathies: human disease and transgenic mouse models

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Cytosolic phospholipase A2 is responsible for prostaglandin E2 and leukotriene B4 formation in phagocyte-like PLB-985 cells: studies of differentiated cPLA2-deficient PLB-985 cells

21 January 2018

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Evidence of Abeta- and transgene-dependent defects in ERK-CREB signaling in Alzheimer's models

21 January 2018

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Prostaglandin E2 regulates amyloid precursor protein expression via the EP2 receptor in cultured rat microglia.

21 January 2018

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Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons

21 January 2018

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Cyclooxygenase (COX)-2 and COX-1 Potentiate β-Amyloid Peptide Generation through Mechanisms That Involve γ-Secretase Activity

21 January 2018

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Reduction of cPLA2alpha overexpression: an efficient anti-inflammatory therapy for collagen-induced arthritis

21 January 2018

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Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration.

21 January 2018

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Cytosolic phospholipase A2α upregulation mediates apoptotic neuronal death induced by aggregated amyloid-β peptide1-42.

21 January 2018

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Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

21 January 2018

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Phosphorylation of APP-CTF-AICD domains and interaction with adaptor proteins: signal transduction and/or transcriptional role--relevance for Alzheimer pathology

21 January 2018

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Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons

21 January 2018

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Amyloid beta-protein precursor accumulates in dystrophic neurites of senile plaques in Alzheimer-type dementia

21 January 2018

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Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain

21 January 2018

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Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration

21 January 2018

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Role of cytosolic phospholipase A2 in oxidative and inflammatory signaling pathways in different cell types in the central nervous system

21 January 2018

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Regulatory role of cytosolic phospholipase A2alpha in NADPH oxidase activity and in inducible nitric oxide synthase induction by aggregated Abeta1-42 in microglia.

21 January 2018

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Amyloid precursor protein trafficking, processing, and function

21 January 2018

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Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling

21 January 2018

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Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type

21 January 2018

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APP processing in Alzheimer's disease

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/JNC.13012

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1 September 2017

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