(Q38306892)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069947%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

title

Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069947%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

author name string

Y Hashimoto

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069947%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

H Jiang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069947%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

T Niikura

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069947%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Y Ito

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069947%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

A Hagiwara

5

1 reference

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1 November 2019

K Umezawa

6

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1 November 2019

Y Abe

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069947%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Y Murayama

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069947%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

I Nishimoto

9

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1 November 2019

language of work or name

English

0 references

publication date

1 November 2000

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1 November 2019

published in

Journal of Neuroscience

1 reference

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1 November 2019

volume

20

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1 November 2019

page(s)

8401-8409

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1 November 2019

issue

22

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A test of the cytosolic apolipoprotein E hypothesis fails to detect the escape of apolipoprotein E from the endocytic pathway into the cytosol and shows that direct expression of apolipoprotein E in the cytosol is cytotoxic.

1 November 2019

cites work

1 reference

12 December 2020

Attenuation of the neurotoxic effect of A beta amyloid peptide by apolipoprotein E.

1 reference

12 December 2020

Bidirectional regulation of c-fos promoter by an oncogenic gip2 mutant of G alpha i2. A novel implication of retinoblastoma gene product.

1 reference

12 December 2020

Distinctive regulation of the functional linkage between the human cation-independent mannose 6-phosphate receptor and GTP-binding proteins by insulin-like growth factor II and mannose 6-phosphate

1 reference

12 December 2020

In vivo coupling of insulin-like growth factor II/mannose 6-phosphate receptor to heteromeric G proteins. Distinct roles of cytoplasmic domains and signal sequestration by the receptor

1 reference

12 December 2020

Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein is increased in reactive and neoplastic glial cells

1 reference

12 December 2020

Neuronal traits of clonal cell lines derived by fusion of dorsal root ganglia neurons with neuroblastoma cells

1 reference

12 December 2020

Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein E-derived peptide.

1 reference

12 December 2020

Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease.

1 reference

12 December 2020

Apolipoprotein E polymorphism in patients with different neurodegenerative disorders.

1 reference

12 December 2020

The polymorphism in exon 3 of the low density lipoprotein receptor-related protein gene is weakly associated with Alzheimer's disease.

1 reference

12 December 2020

Modulation of the age at onset of Parkinson's disease by apolipoprotein E genotypes

1 reference

12 December 2020

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

1 reference

12 December 2020

Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpha 2MR, and the receptor-associated protein (RAP)

1 reference

12 December 2020

Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo

1 reference

12 December 2020

Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis.

1 reference

12 December 2020

Conversion of G-protein specificity of insulin-like growth factor II/mannose 6-phosphate receptor by exchanging of a short region with beta-adrenergic receptor

1 reference

12 December 2020

Apolipoprotein E polymorphism in patients with Alzheimer's disease, vascular dementia and ischemic cerebrovascular disease.

1 reference

12 December 2020

Isoform-specific binding of apolipoprotein E to beta-amyloid

1 reference

12 December 2020

Increased susceptibility to sporadic Parkinson's disease by a certain combined alpha-synuclein/apolipoprotein E genotype

1 reference

12 December 2020

Effect of apolipoprotein E on neurite outgrowth and beta-amyloid-induced toxicity in developing rat primary hippocampal cultures

1 reference

12 December 2020

Baculovirus-mediated expression of human apolipoprotein E in Manduca sexta larvae generates particles that bind to the low density lipoprotein receptor

1 reference

12 December 2020

Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene.

1 reference

12 December 2020

Etorphine inhibits cell growth and induces apoptosis in SK-N-SH cells: involvement of pertussis toxin-sensitive G proteins

1 reference

12 December 2020

A high frequency of apolipoprotein E4 isoprotein in Japanese patients with late-onset nonfamilial Alzheimer's disease.

1 reference

12 December 2020

Apolipoprotein E epsilon 4 allele is not associated with earlier age at onset in amyotrophic lateral sclerosis

1 reference

12 December 2020

No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease.

1 reference

12 December 2020

Neurite degeneration elicited by apolipoprotein E peptides

1 reference

12 December 2020

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

1 reference

12 December 2020

Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

1 reference

12 December 2020

Complement C5a anaphylatoxin fragment causes apoptosis in TGW neuroblastoma cells

1 reference

12 December 2020

Apolipoprotein E polymorphism in Pick's disease and in Huntington's disease

1 reference

12 December 2020

Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages

1 reference

12 December 2020

Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts

1 reference

12 December 2020

Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer's disease.

1 reference

12 December 2020

Receptors of the low density lipoprotein (LDL) receptor family in man. Multiple functions of the large family members via interaction with complex ligands.

1 reference

12 December 2020

Lack of association of the alpha2-macroglobulin locus on chromosome 12 in AD.

1 reference

12 December 2020

Isolation and characterization of apolipoprotein E

1 reference

12 December 2020

Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.

1 reference

12 December 2020

Alpha-2-macroglobulin intronic polymorphism is not associated with autopsy-confirmed late-onset Alzheimer's disease.

1 reference

12 December 2020

Subcellular localization of the low density lipoprotein receptor-related protein (alpha 2-macroglobulin receptor) in human brain.

1 reference

12 December 2020

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

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12 December 2020

Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutations of amyloid precursor protein.

1 reference

12 December 2020

The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

1 reference

12 December 2020

Introduction of DNA into rat liver with a hand-held gene gun: distribution of the expressed enzyme, [32P]DNA, and Ca2+ flux

1 reference

12 December 2020

G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP.

1 reference

12 December 2020

The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development

1 reference

12 December 2020

Activation of G proteins bidirectionally affects apoptosis of cultured cerebellar granule neurons

1 reference

12 December 2020

Lack of association of a polymorphism in the low-density lipoprotein receptor-related protein gene with Alzheimer disease.

1 reference

12 December 2020

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females

1 reference

12 December 2020

Purification of apolipoprotein E attenuates isoform-specific binding to beta-amyloid

1 reference

12 December 2020

Lack of association between apolipoprotein E genotype and sporadic amyotrophic lateral sclerosis.

1 reference

12 December 2020

Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins.

1 reference

12 December 2020

Alpha2-macroglobulin polymorphism is not associated with AD or AD-type neuropathology in the Japanese.

1 reference

12 December 2020

Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease

1 reference

12 December 2020

G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.

1 reference

12 December 2020

Regulation of brain G-protein go by Alzheimer's disease gene presenilin-1.

1 reference

12 December 2020

A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicity.

1 reference

12 December 2020

Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.

1 reference

12 December 2020

Inhibition of the omega-conotoxin-sensitive calcium current by distinct G proteins

1 reference

12 December 2020

Apolipoprotein E genotyping in sporadic amyotrophic lateral sclerosis: evidence for a major influence on the clinical presentation and prognosis.

1 reference

12 December 2020

Isoform-specific effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures.

1 reference

12 December 2020

Endothelin-induced apoptosis of A375 human melanoma cells

1 reference

12 December 2020

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

1 reference

12 December 2020

Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes.

1 reference

12 December 2020

Risky apolipoprotein in brain

1 reference

12 December 2020

Association between the low density lipoprotein receptor-related protein (LRP) and Alzheimer's disease.

1 reference

12 December 2020

Association at LRP gene locus with sporadic late-onset Alzheimer's disease.

1 reference

12 December 2020

Protease inhibitors generate cytotoxic fragments from Alzheimer amyloid protein precursor in cDNA-transfected glioma cells

1 reference

12 December 2020

Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity.

1 reference

12 December 2020

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

12 December 2020

Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain

1 reference

12 December 2020

The apolipoprotein E epsilon 4 allele in Parkinson's disease with Alzheimer lesions.

1 reference

12 December 2020

Alpha2 macroglobulin and the risk of Alzheimer's disease.

1 reference

12 December 2020

Alpha2-macroglobulin gene polymorphisms show racial diversity and are not associated with Alzheimer's disease

1 reference

12 December 2020

The deletion polymorphism and Val1000Ile in alpha-2-macroglobulin and Alzheimer disease in Caribbean Hispanics

1 reference

12 December 2020

Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein

1 reference

12 December 2020

Beta-amyloid peptide interacts specifically with the carboxy-terminal domain of human apolipoprotein E: relevance to Alzheimer's disease.

1 reference

12 December 2020

Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediated

1 reference

12 December 2020

Association between an alpha(2) macroglobulin DNA polymorphism and late-onset Alzheimer's disease

1 reference

12 December 2020

The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor.

1 reference

12 December 2020

Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population

1 reference

12 December 2020

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

1 reference

12 December 2020

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)

1 reference

12 December 2020

Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease

1 reference

12 December 2020

Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons.

1 reference

12 December 2020

Apolipoprotein E genotype in familial Parkinson's disease. The French Parkinson's Disease Genetics Study Group

1 reference

12 December 2020

Low density lipoprotein receptor related protein gene exon 3 polymorphism association with Alzheimer's disease in Chinese.

1 reference

12 December 2020

No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample.

1 reference

12 December 2020

Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

1 reference

12 December 2020

A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal

1 reference

12 December 2020

Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E

1 reference

12 December 2020

The expression of the LDL receptor-related protein (LRP) correlates with the differentiation of human neuroblastoma cells

1 reference

12 December 2020

A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteins

1 reference

12 December 2020

Rapid elevation of neuronal cytoplasmic calcium by apolipoprotein E peptide

1 reference

12 December 2020

Association between coding variability in the LRP gene and the risk of late-onset Alzheimer's disease.

1 reference

12 December 2020

Alpha-2 macroglobulin is genetically associated with Alzheimer disease.

1 reference

12 December 2020

10.1523/JNEUROSCI.20-22-08401.2000

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069947%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069947%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

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