(Q38315892)

2 September 2017

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors (English)

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2 September 2017

7

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2 September 2017

Arno Velds

5

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author name string

Thijn R Brummelkamp

1

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2 September 2017

Armida W M Fabius

2

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2 September 2017

Jasper Mullenders

3

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2 September 2017

Mandy Madiredjo

4

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2 September 2017

Ron M Kerkhoven

6

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2 September 2017

Roderick L Beijersbergen

8

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2 September 2017

13 February 2006

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2 September 2017

Nature Chemical Biology

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2 September 2017

2

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2 September 2017

202-206

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2 September 2017

4

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https://scigraph.springernature.com/pub.10.1038/nchembio774

2 September 2017

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cites work

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

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7 January 2021

Turning the key on p53.

1 reference

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7 January 2021

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

Genetic and genomic approaches to identify and study the targets of bioactive small molecules.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

New tools for functional mammalian cancer genetics

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

A resource for large-scale RNA-interference-based screens in mammals.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

A genetic screen for candidate tumor suppressors identifies REST

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

Functional identification of cancer-relevant genes through large-scale RNA interference screens in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

A novel p53 transcriptional repressor element (p53TRE) and the asymmetrical contribution of two p53 binding sites modulate the response of the placental transforming growth factor-beta promoter to p53

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

53BP1, a mediator of the DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

Caffeine inhibits the checkpoint kinase ATM

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

Genetic instabilities in human cancers

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

Platinum(II)-based coordination compounds as nucleic acid labeling reagents: synthesis, reactivity, and applications in hybridization assays.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

Microarray data normalization and transformation

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO774

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO774

1 reference

2 September 2017

1 reference