(Q38327407)

English

The tyrosines in the bidentate motif of the env-sea oncoprotein are essential for cell transformation and are binding sites for Grb2 and the tyrosine phosphatase SHP-2.

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scholarly article

1 reference

Europe PubMed Central

2 September 2017

The tyrosines in the bidentate motif of the env-sea oncoprotein are essential for cell transformation and are binding sites for Grb2 and the tyrosine phosphatase SHP-2. (English)

1 reference

Europe PubMed Central

2 September 2017

author name string

Park CY

1

1 reference

Europe PubMed Central

2 September 2017

Hayman MJ

2

1 reference

Europe PubMed Central

2 September 2017

language of work or name

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publication date

1 March 1999

1 reference

Europe PubMed Central

2 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

2 September 2017

274

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Europe PubMed Central

2 September 2017

7583-7590

1 reference

Europe PubMed Central

2 September 2017

11

1 reference

Europe PubMed Central

2 September 2017

Molecular themes in oncogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Cooperation between oncogenes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

SH2 and SH3 domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Protein modules and signalling networks

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

SH2 domains recognize specific phosphopeptide sequences

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

The v-sea oncogene of avian erythroblastosis retrovirus S13: another member of the protein-tyrosine kinase gene family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

The putative transforming protein of S13 avian erythroblastosis virus is a transmembrane glycoprotein with an associated protein kinase activity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Temperature-sensitive v-sea transformed erythroblasts: a model system to study gene expression during erythroid differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

The protooncogene c-sea encodes a transmembrane protein-tyrosine kinase related to the Met/hepatocyte growth factor/scatter factor receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Identification of two additional v-sea-encoded proteins in avian erythroblastosis virus, S13-infected fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

High-efficiency transformation of mammalian cells by plasmid DNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Structure and function of SH2-domain containing tyrosine phosphatases.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

From form to function: signaling by protein tyrosine phosphatases.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Roles of protein-tyrosine phosphatases in growth factor signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Form and function in protein dephosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Altered expression of protein-tyrosine phosphatase 2C in 293 cells affects protein tyrosine phosphorylation and mitogen-activated protein kinase activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Constitutive activation of the RON gene promotes invasive growth but not transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

A point mutation in the MET oncogene abrogates metastasis without affecting transformation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7583

21 January 2018

Identifiers

10.1074/JBC.274.11.7583

1 reference

Europe PubMed Central

2 September 2017

1 reference

Europe PubMed Central

2 September 2017

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