(Q38340048)

2 September 2017

Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302. (English)

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2 September 2017

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Eric D Werner

1

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2 September 2017

Jongsoon Lee

2

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2 September 2017

Lone Hansen

3

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2 September 2017

Minsheng Yuan

4

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2 September 2017

Steven E Shoelson

5

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2 September 2017

language of work or name

English

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publication date

14 June 2004

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Journal of Biological Chemistry

2 September 2017

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2 September 2017

279

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2 September 2017

35298-35305

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2 September 2017

34

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Diabetes trends in the U.S.: 1990-1998.

2 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

A central role for JNK in obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Decreased phosphorylation of mutant insulin receptor by protein kinase C and protein kinase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Phosphorylation of purified insulin receptor by cAMP kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Frap-dependent serine phosphorylation of IRS-1 inhibits IRS-1 tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Transactivation of ErbB2 and ErbB3 by tumor necrosis factor-alpha and anisomycin leads to impaired insulin signaling through serine/threonine phosphorylation of IRS proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Role of mTOR in the degradation of IRS-1: regulation of PP2A activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

The PI3-kinase serine kinase phosphorylates its p85 subunit and IRS-1 in PI3-kinase/IRS-1 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Active Rho kinase (ROK-alpha ) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Insulin sensitivity and its measurement: structural commonalities among the methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Insulin-receptor autophosphorylation and endogenous substrate phosphorylation in human adipocytes from control, obese, and NIDDM subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

The Sequence of the Human Genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

The protein kinase complement of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

Yeast forward and reverse 'n'-hybrid systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405203200

21 January 2018

Identifiers

DOI

10.1074/JBC.M405203200

1 reference

2 September 2017

1 reference