(Q38363869)

2 September 2017

title

Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase (English)

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2 September 2017

4

F Peter Guengerich

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2 September 2017

Liping Liu

1

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2 September 2017

Anthony E Pegg

series ordinal

2

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2 September 2017

Kevin M Williams

series ordinal

3

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2 September 2017

language of work or name

English

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publication date

31 July 2002

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Journal of Biological Chemistry

2 September 2017

published in

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2 September 2017

volume

277

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2 September 2017

issue

40

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2 September 2017

page(s)

37920-37928

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Regulation and expression of the adaptive response to alkylating agents

2 September 2017

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Bacterial and mammalian DNA alkyltransferases sensitize Escherichia coli to the lethal and mutagenic effects of dibromoalkanes.

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The role of human O(6)-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in Escherichia coli

21 January 2018

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The effectiveness of the O(6)-alkylguanine-DNA alkyltransferase encoded by the ogt(ST) gene from S. typhimurium in protection against alkylating drugs, resistance to O(6)-benzylguanine and sensitisation to dibromoalkane genotoxicity

21 January 2018

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Mammalian cells expressing Escherichia coli O6-alkylguanine-DNA alkyltransferases are hypersensitive to dibromoalkanes.

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Genotoxic effects of 1,2-dibromoethane and 1,2-dichloroethane

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An analysis of the mutagenicity of 1,2-dibromoethane to Escherichia coli: influence of DNA repair activities and metabolic pathways

21 January 2018

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Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

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The role of glutathione conjugation in the mutagenicity of 1,2-dibromoethane

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Decreased dimethylnitrosamine-induced O6- and N7-methyldeoxyguanosine levels correlate with development and progression of lesions in rat hepatocarcinogenesis

21 January 2018

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Evidence for formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA.

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Pyridyloxobutyl adduct O6-[4-oxo-4-(3-pyridyl)butyl]guanine is present in 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-treated DNA and is a substrate for O6-alkylguanine-DNA alkyltransferase.

21 January 2018

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21 January 2018

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Expression of the inactive C145A mutant human O6-alkylguanine-DNA alkyltransferase in E.coli increases cell killing and mutations by N-methyl-N'-nitro-N-nitrosoguanidine.

21 January 2018

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21 January 2018

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Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents

21 January 2018

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Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine

21 January 2018

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Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding

21 January 2018

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Degradation of the alkylated form of the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase

21 January 2018

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21 January 2018

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Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine

21 January 2018

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21 January 2018

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21 January 2018

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ogt alkyltransferase enhances dibromoalkane mutagenicity in excision repair–deficientescherichia coli K-12

21 January 2018

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Human O6 -alkylguanine-DNA alkyltransferase: protection against alkylating agents and sensitization to dibromoalkanes

21 January 2018

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The metabolic formation of N-acetyl-S-2-hydroxyethyl-L-cysteine from tetradeutero-1,2-dibromoethane. relative importance of oxidation and glutathione conjugation in vivo

21 January 2018

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Roles of the vinyl chloride oxidation products 1-chlorooxirane and 2-chloroacetaldehyde in the in vitro formation of etheno adducts of nucleic acid bases [corrected]

21 January 2018

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Mechanism of formation of ethenoguanine adducts from 2-haloacetaldehydes: 13C-labeling patterns with 2-bromoacetaldehyde

21 January 2018

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Polymerase blockage and misincorporation of dNTPs opposite the ethylene dibromide-derived DNA adducts S-[2-(N7-guanyl)ethyl]glutathione, S-[2-(N2-guanyl)ethyl]glutathione, and S-[2-(O6-guanyl)ethyl]glutathione

21 January 2018

1 reference

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Repair of O6-benzylguanine by the Escherichia coli Ada and Ogt and the human O6-alkylguanine-DNA alkyltransferases

21 January 2018

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Synthesis of oligonucleotides containing the ethylene dibromide-derived DNA adducts S-[2-(N7-guanyl)ethyl]glutathione, S-[2-(N2-guanyl)ethyl]glutathione, and S-[2-(O6-guanyl)ethyl]glutathione at a single site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205548200

21 January 2018

Identifiers

DOI

10.1074/JBC.M205548200

1 reference

2 September 2017

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