(Q38529724)

3 September 2017

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title

Control of mammalian gene expression by selective mRNA export (English)

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Vihandha O Wickramasinghe

3 September 2017

object named as

Vihandha O Wickramasinghe

series ordinal

1

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author name string

Ronald A Laskey

series ordinal

2

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3 September 2017

17 June 2015

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Nature Reviews Molecular Cell Biology

3 September 2017

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3 September 2017

16

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3 September 2017

431-442

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3 September 2017

7

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https://scigraph.springernature.com/pub.10.1038/nrm4010

3 September 2017

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cites work

Human mRNA export machinery recruited to the 5' end of mRNA

1 reference

Recruitment of the human TREX complex to mRNA during splicing

21 January 2018

1 reference

TREX is a conserved complex coupling transcription with messenger RNA export

21 January 2018

1 reference

The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans

21 January 2018

1 reference

Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export

21 January 2018

1 reference

Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex

21 January 2018

1 reference

Sus1, Cdc31, and the Sac3 CID Region Form a Conserved Interaction Platform that Promotes Nuclear Pore Association and mRNA Export

21 January 2018

1 reference

Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery

21 January 2018

1 reference

The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores

21 January 2018

1 reference

The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates

21 January 2018

1 reference

The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human

21 January 2018

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mRNA export from mammalian cell nuclei is dependent on GANP.

21 January 2018

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Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP

21 January 2018

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Selective nuclear export of specific classes of mRNA from mammalian nuclei is promoted by GANP.

21 January 2018

1 reference

Human inositol polyphosphate multikinase regulates transcript-selective nuclear mRNA export to preserve genome integrity

21 January 2018

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The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming

21 January 2018

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The oncogene eIF4E reprograms the nuclear pore complex to promote mRNA export and oncogenic transformation

21 January 2018

1 reference

Identification of mRNAs that are spliced but not exported to the cytoplasm in the absence of THOC5 in mouse embryo fibroblasts

21 January 2018

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THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo

21 January 2018

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Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP

21 January 2018

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Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA

21 January 2018

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eIF4E is a central node of an RNA regulon that governs cellular proliferation

21 January 2018

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Regulation of mRNA trafficking by nuclear pore complexes.

21 January 2018

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mRNA nuclear export in yeast

21 January 2018

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Postage for the messenger: designating routes for nuclear mRNA export

21 January 2018

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mRNA export and the TREX complex

21 January 2018

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Keeping mRNPs in check during assembly and nuclear export.

21 January 2018

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Linking gene regulation to mRNA production and export.

21 January 2018

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Nuclear export dynamics of RNA-protein complexes.

21 January 2018

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A day in the life of the spliceosome

21 January 2018

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Coupling mRNA processing with transcription in time and space.

21 January 2018

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How cells get the message: dynamic assembly and function of mRNA-protein complexes

21 January 2018

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Counting on co-transcriptional splicing

21 January 2018

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A role for TREX components in the release of spliced mRNA from nuclear speckle domains

21 January 2018

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Poly(A)+ RNAs roam the cell nucleus and pass through speckle domains in transcriptionally active and inactive cells

21 January 2018

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Nuclear speckles: a model for nuclear organelles

21 January 2018

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In vivo analysis of the stability and transport of nuclear poly(A)+ RNA.

21 January 2018

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Real-time dynamics of RNA polymerase II clustering in live human cells

21 January 2018

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Spatial organization of RNA polymerase II inside a mammalian cell nucleus revealed by reflected light-sheet superresolution microscopy.

21 January 2018

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Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors

21 January 2018

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Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum.

21 January 2018

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Akt phosphorylation and nuclear phosphoinositide association mediate mRNA export and cell proliferation activities by ALY.

21 January 2018

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Clustering of multiple specific genes and gene-rich R-bands around SC-35 domains: evidence for local euchromatic neighborhoods

21 January 2018

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To the pore and through the pore: a story of mRNA export kinetics

21 January 2018

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The dynamic pathway of nuclear RNA in eukaryotes

21 January 2018

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Nuclear export of single native mRNA molecules observed by light sheet fluorescence microscopy

21 January 2018

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Dynamics of single mRNP nucleocytoplasmic transport and export through the nuclear pore in living cells.

21 January 2018

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In vivo imaging of labelled endogenous β-actin mRNA during nucleocytoplasmic transport

21 January 2018

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Dynamics of single mRNPs in nuclei of living cells.

21 January 2018

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Movement of nuclear poly(A) RNA throughout the interchromatin space in living cells

21 January 2018

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The life of an mRNA in space and time

21 January 2018

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Nucleocytoplasmic transport of proteins and poly(A)+ RNA in reconstituted Tpr-less nuclei in living mammalian cells

21 January 2018

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Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion

21 January 2018

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The human TREX-2 complex is stably associated with the nuclear pore basket.

21 January 2018

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TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export

21 January 2018

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Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1

21 January 2018

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Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor

21 January 2018

1 reference

The permeability of reconstituted nuclear pores provides direct evidence for the selective phase model

21 January 2018

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Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA.

21 January 2018

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The Tpr protein regulates export of mRNAs with retained introns that traffic through the Nxf1 pathway

21 January 2018

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Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention

21 January 2018

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The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner

21 January 2018

1 reference

A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export

21 January 2018

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Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export

21 January 2018

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The Dbp5 cycle at the nuclear pore complex during mRNA export II: nucleotide cycling and mRNP remodeling by Dbp5 are controlled by Nup159 and Gle1

21 January 2018

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The Dbp5 cycle at the nuclear pore complex during mRNA export I: dbp5 mutants with defects in RNA binding and ATP hydrolysis define key steps for Nup159 and Gle1

21 January 2018

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Dbp5, Gle1-IP6 and Nup159: a working model for mRNP export

21 January 2018

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Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export

21 January 2018

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ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex

21 January 2018

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The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability

21 January 2018

1 reference

A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae

21 January 2018

1 reference

Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export

21 January 2018

1 reference

REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export.

21 January 2018

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Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.

21 January 2018

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Definition of global and transcript-specific mRNA export pathways in metazoans

21 January 2018

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Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly

21 January 2018

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Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p

21 January 2018

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Chtop is a component of the dynamic TREX mRNA export complex

21 January 2018

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The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export

21 January 2018

1 reference

UIF, a New mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA

21 January 2018

1 reference

Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA

21 January 2018

1 reference

Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor

21 January 2018

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Comprehensive proteomic analysis of the human spliceosome

21 January 2018

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The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus

21 January 2018

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SRprises along a messenger's journey

21 January 2018

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A molecular link between SR protein dephosphorylation and mRNA export

21 January 2018

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Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA

21 January 2018

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SR splicing factors serve as adapter proteins for TAP-dependent mRNA export

21 January 2018

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Evidence that a consensus element found in naturally intronless mRNAs promotes mRNA export

21 January 2018

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NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs.

21 January 2018

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Knockdown of SLBP results in nuclear retention of histone mRNA

21 January 2018

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Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery

21 January 2018

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A systems view of mRNP biology

21 January 2018

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Genome-wide analysis of nuclear mRNA export pathways in Drosophila

21 January 2018

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A transcriptome-wide atlas of RNP composition reveals diverse classes of mRNAs and lncRNAs

21 January 2018

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Transcriptome Maps of mRNP Biogenesis Factors Define Pre-mRNA Recognition

21 January 2018

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Recruitment of TREX to the transcription machinery by its direct binding to the phospho-CTD of RNA polymerase II

21 January 2018

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Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles

21 January 2018

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Depletion of REF/Aly alters gene expression and reduces RNA polymerase II occupancy

21 January 2018

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Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery

21 January 2018

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SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope

21 January 2018

1 reference

MCM3AP is transcribed from a promoter within an intron of the overlapping gene for GANP.

21 January 2018

1 reference

GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy

21 January 2018

1 reference

CRM1-mediated nuclear export: to the pore and beyond.

21 January 2018

1 reference

Aiding and abetting cancer: mRNA export and the nuclear pore

21 January 2018

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Exporting RNA from the nucleus to the cytoplasm

21 January 2018

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hnRNP C tetramer measures RNA length to classify RNA polymerase II transcripts for export.

21 January 2018

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Protein ligands to HuR modulate its interaction with target mRNAs in vivo

21 January 2018

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21 January 2018

1 reference

Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin.

21 January 2018

1 reference

The eIF4E RNA regulon promotes the Akt signaling pathway

21 January 2018

1 reference

Post-transcriptional RNA regulons affecting cell cycle and proliferation

21 January 2018

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RNA regulons: coordination of post-transcriptional events

21 January 2018

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Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB.

21 January 2018

1 reference

Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity

21 January 2018

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Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate

21 January 2018

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Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early sudden cardiac death

21 January 2018

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Nucleoporin levels regulate cell cycle progression and phase-specific gene expression

21 January 2018

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The Nucleoporin Nup96 Is Required for Proper Expression of Interferon-Regulated Proteins and Functions

21 January 2018

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21 January 2018

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Hallmarks of Cancer: The Next Generation

21 January 2018

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Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

21 January 2018

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Frequent pathway mutations of splicing machinery in myelodysplasia

21 January 2018

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Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts

21 January 2018

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Increased expression of germinal center-associated nuclear protein RNA-primase is associated with lymphomagenesis.

21 January 2018

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Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers

21 January 2018

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An integrated approach in the discovery and characterization of a novel nuclear protein over-expressed in liver and pancreatic tumors

21 January 2018

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Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

21 January 2018

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Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

21 January 2018

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Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease

21 January 2018

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Deleterious mutations in the essential mRNA metabolism factor, hGle1, in amyotrophic lateral sclerosis

21 January 2018

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A syndrome of multiple congenital contractures: neuropathological analysis on five fetal cases

21 January 2018

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A lethal autosomal recessive syndrome of multiple congenital contractures

21 January 2018

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Gle1 functions during mRNA export in an oligomeric complex that is altered in human disease

21 January 2018

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R loops: from transcription byproducts to threats to genome stability

21 January 2018

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Cotranscriptionally Formed DNA:RNA Hybrids Mediate Transcription Elongation Impairment and Transcription-Associated Recombination

21 January 2018

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The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability.

21 January 2018

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Genome instability and transcription elongation impairment in human cells depleted of THO/TREX

21 January 2018

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BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.

21 January 2018

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Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines

21 January 2018

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RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export.

21 January 2018

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The nucleoporin nup153 plays a critical role in multiple types of nuclear export

21 January 2018

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Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling

21 January 2018

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A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export

21 January 2018

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Centrin 2 localizes to the vertebrate nuclear pore and plays a role in mRNA and protein export

21 January 2018

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Sem1 is a functional component of the nuclear pore complex-associated messenger RNA export machinery

21 January 2018

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A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing

21 January 2018

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High-resolution three-dimensional mapping of mRNA export through the nuclear pore

21 January 2018

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Eukaryotic mRNPs may represent posttranscriptional operons

31 March 2020

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ALY as a potential contributor to metastasis in human oral squamous cell carcinoma

31 March 2020

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Linking transcriptional elongation and messenger RNA export to metastatic breast cancers

31 March 2020

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Dss1 associating with the proteasome functions in selective nuclear mRNA export in yeast

31 March 2020

1 reference

Nuclear PtdIns(4,5)P2 assembles in a mitotically regulated particle involved in pre-mRNA splicing

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26081607

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRM4010

1 reference

PubMed ID

26081607

Dimensions Publication ID

3 September 2017

0 references

1 reference

PubMed ID

26081607