(Q38587668)

4 September 2017

title

A basic overview of multiple sclerosis immunopathology (English)

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4 September 2017

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N Grigoriadis

1

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4 September 2017

V van Pesch

series ordinal

2

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4 September 2017

ParadigMS Group

series ordinal

3

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4 September 2017

publication date

1 October 2015

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European Journal of Neurology

4 September 2017

published in

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4 September 2017

volume

22 Suppl 2

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4 September 2017

page(s)

3-13

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Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis

4 September 2017

cites work

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21 January 2018

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Multiple sclerosis genetics--is the glass half full, or half empty?

21 January 2018

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Two subsets of dendritic cells are present in human cerebrospinal fluid

21 January 2018

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Dendritic cells in multiple sclerosis: key players in the immunopathogenesis, key players for new cellular immunotherapies?

21 January 2018

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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

21 January 2018

1 reference

Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12

21 January 2018

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Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis

21 January 2018

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T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-beta.

21 January 2018

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Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis

21 January 2018

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Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis.

21 January 2018

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Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis

21 January 2018

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Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis

21 January 2018

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Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells.

21 January 2018

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Cellular mechanisms of IL-17-induced blood-brain barrier disruption

21 January 2018

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How do immune cells overcome the blood-brain barrier in multiple sclerosis?

21 January 2018

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Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation

21 January 2018

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Reduced severity of experimental autoimmune encephalomyelitis in GMF-deficient mice

21 January 2018

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RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.

21 January 2018

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GM-CSF-dependent, CD103+ dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization.

21 January 2018

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Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease.

21 January 2018

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Immunopathogenesis and immunotherapy of multiple sclerosis

21 January 2018

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21 January 2018

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Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis

21 January 2018

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Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis

21 January 2018

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Production and functions of IL-17 in microglia

21 January 2018

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Interactions between microglia and T cells in multiple sclerosis pathobiology.

21 January 2018

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CCR1+/CCR5+ mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis.

21 January 2018

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Fate mapping analysis reveals that adult microglia derive from primitive macrophages

21 January 2018

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A lineage of myeloid cells independent of Myb and hematopoietic stem cells

21 January 2018

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Differential roles of microglia and monocytes in the inflamed central nervous system

21 January 2018

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The formation of inflammatory demyelinated lesions in cerebral white matter.

21 January 2018

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Expansion and preferential activation of the CD14(+)CD16(+) monocyte subset during multiple sclerosis.

21 January 2018

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The yin and yang of microglia

21 January 2018

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Protective effects of microglia in multiple sclerosis.

21 January 2018

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M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

21 January 2018

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Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes

21 January 2018

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Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells.

21 January 2018

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Role of CD8 T cell subsets in the pathogenesis of multiple sclerosis

21 January 2018

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CD8(+) T cells in multiple sclerosis.

21 January 2018

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Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on α4 integrin.

21 January 2018

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Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction

21 January 2018

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Disease exacerbation of multiple sclerosis is characterized by loss of terminally differentiated autoregulatory CD8+ T cells.

21 January 2018

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High-throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV-reactive CD8+ T cells

21 January 2018

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Clonal expansions of activated gamma/delta T cells in recent-onset multiple sclerosis

21 January 2018

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Enriched CD161high CCR6+ γδ T cells in the cerebrospinal fluid of patients with multiple sclerosis

21 January 2018

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Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis

21 January 2018

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CD16+ gammadelta T cells mediate antibody dependent cellular cytotoxicity: potential mechanism in the pathogenesis of multiple sclerosis.

21 January 2018

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Mechanism of gammadelta T cell-induced human oligodendrocyte cytotoxicity: relevance to multiple sclerosis

21 January 2018

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γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism.

21 January 2018

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Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.

21 January 2018

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NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor

21 January 2018

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Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells

21 January 2018

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Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responses

21 January 2018

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Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis.

21 January 2018

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Targets of the humoral autoimmune response in multiple sclerosis

21 January 2018

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B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes

21 January 2018

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Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis.

21 January 2018

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B cells and antibodies in MS.

21 January 2018

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Clonally expanded plasma cells in the cerebrospinal fluid of patients with central nervous system autoimmune demyelination produce "oligoclonal bands".

21 January 2018

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Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination

21 January 2018

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Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology.

21 January 2018

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Specific peripheral B cell tolerance defects in patients with multiple sclerosis

21 January 2018

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IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

21 January 2018

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B cells regulate autoimmunity by provision of IL-10.

21 January 2018

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Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial

21 January 2018

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Emerging roles of astrocytes in neural circuit development

21 January 2018

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Inhibition of reactive astrocytosis in established experimental autoimmune encephalomyelitis favors infiltration by myeloid cells over T cells and enhances severity of disease.

21 January 2018

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Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation.

21 January 2018

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High fat diet exacerbates neuroinflammation in an animal model of multiple sclerosis by activation of the Renin Angiotensin system.

21 January 2018

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Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

21 January 2018

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Gut microbiome and the risk factors in central nervous system autoimmunity.

21 January 2018

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Gut commensalism, cytokines, and central nervous system demyelination

21 January 2018

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Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination.

21 January 2018

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Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

21 January 2018

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Diagnosis of inflammatory demyelination in biopsy specimens: a practical approach

21 January 2018

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Mechanisms of white matter damage in multiple sclerosis

21 January 2018

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Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time

21 January 2018

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Diffuse axonal and tissue injury in patients with multiple sclerosis with low cerebral lesion load and no disability

21 January 2018

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Axonal damage in multiple sclerosis: a complex issue in a complex disease

21 January 2018

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Axonal transection in the lesions of multiple sclerosis

21 January 2018

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Mitochondrial changes within axons in multiple sclerosis

21 January 2018

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Progressive ventricular enlargement in patients with clinically isolated syndromes is associated with the early development of multiple sclerosis

21 January 2018

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Clinical relevance of brain volume measures in multiple sclerosis

21 January 2018

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Cortical demyelination and diffuse white matter injury in multiple sclerosis.

21 January 2018

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Subpial demyelination in the cerebral cortex of multiple sclerosis patients

21 January 2018

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Multiple sclerosis: lessons from molecular neuropathology

21 January 2018

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Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron

21 January 2018

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Multiple sclerosis - candidate mechanisms underlying CNS atrophy

21 January 2018

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Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis.

21 January 2018

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Clinical trials of multiple sclerosis therapies: improvements to demonstrate long-term patient benefit

21 January 2018

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The immune pathogenesis of multiple sclerosis.

21 January 2018

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Drugs in development for relapsing multiple sclerosis

21 January 2018

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Neuroinflammation in multiple sclerosis: evidence for autoimmune dysregulation, not simple autoimmune reaction

21 January 2018

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Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy

21 January 2018

1 reference

Impact of alemtuzumab treatment on the survival and function of human regulatory T cells in vitro.

21 January 2018

1 reference

Differential reconstitution of T cell subsets following immunodepleting treatment with alemtuzumab (anti-CD52 monoclonal antibody) in patients with relapsing-remitting multiple sclerosis.

21 January 2018

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Multiple sclerosis: reprogramming the immune repertoire with alemtuzumab in MS.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/ENE.12798

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4 September 2017

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