(Q38782465)

6 September 2017

Grouping 34 Chemicals Based on Mode of Action Using Connectivity Mapping (English)

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6 September 2017

K Nadira De Abrew

1

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6 September 2017

Raghunandan M Kainkaryam

2

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6 September 2017

Yuqing K Shan

3

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6 September 2017

Gary J Overmann

4

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6 September 2017

Raja S Settivari

5

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6 September 2017

Xiaohong Wang

6

1 reference

6 September 2017

Jun Xu

7

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6 September 2017

Rachel L Adams

8

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6 September 2017

Jay P Tiesman

9

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6 September 2017

Edward W Carney

10

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6 September 2017

Jorge M Naciff

11

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6 September 2017

George P Daston

12

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6 September 2017

29 March 2016

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6 September 2017

Toxicological Sciences

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6 September 2017

151

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6 September 2017

447-461

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6 September 2017

2

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An Improved Bacterial Test System for the Detection and Classification of Mutagens and Carcinogens

6 September 2017

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Biokinetic modeling and in vitro-in vivo extrapolations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Development of an androgen reporter gene assay (AR-LUX) utilizing a human cell line with an endogenously regulated androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

IPCS framework for analyzing the relevance of a cancer mode of action for humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

IPCS framework for analyzing the relevance of a noncancer mode of action for humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Toxicology. Transforming environmental health protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

SEURAT: Safety Evaluation Ultimately Replacing Animal Testing--recommendations for future research in the field of predictive toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

US Environmental Protection Agency's revised guidelines for Carcinogen Risk Assessment: incorporating mode of action data

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

The ToxCast program for prioritizing toxicity testing of environmental chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Identification of a nuclear receptor that is activated by farnesol metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

affy--analysis of Affymetrix GeneChip data at the probe level

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Development of a peptide reactivity assay for screening contact allergens

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

The estrogen receptor gene: promoter organization and expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Summaries of Affymetrix GeneChip probe level data

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

DNA methylation of estrogen receptor alpha gene by phthalates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Expression of RANK is dependent upon differentiation into the macrophage/osteoclast lineage: induction by 1alpha,25-dihydroxyvitamin D3 and TPA in a human myelomonocytic cell line, HL60.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Predictive models and computational toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Antibiotic amoxicillin induces DNA lesions in mammalian cells possibly via the reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Xenoestrogens and the induction of proliferative effects in breast cancer cells via direct activation of oestrogen receptor alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Reactive oxygen species-independent oxidation of thioredoxin in hypoxia: inactivation of ribonucleotide reductase and redox-mediated checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

A unified nomenclature system for the nuclear receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Microarrays and toxicology: the advent of toxicogenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Antiepileptic drugs inhibit cell growth in the human breast cancer cell line MCF7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Griseofulvin stabilizes microtubule dynamics, activates p53 and inhibits the proliferation of MCF-7 cells synergistically with vinblastine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Effect of selected insecticides on growth rate and stress protein expression in cultured human A549 and SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

limma powers differential expression analyses for RNA-sequencing and microarray studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Accelerating the development of 21st-century toxicology: outcome of a Human Toxicology Project Consortium workshop

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Thyroid hormone causes mitogen-activated protein kinase-dependent phosphorylation of the nuclear estrogen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Toward the identification of liver toxicity markers: a proteome study in human cell culture and rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Improving the human hazard characterization of chemicals: a Tox21 update

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Rapid and sensitive reporter gene assays for detection of antiandrogenic and estrogenic effects of environmental chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

The adverse outcome pathway concept: a pragmatic tool in toxicology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

The food contaminants bisphenol A and 4-nonylphenol act as agonists for estrogen receptor alpha in MCF7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Incorporating population variability and susceptible subpopulations into dosimetry for high-throughput toxicity testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

A framework for using structural, reactivity, metabolic and physicochemical similarity to evaluate the suitability of analogs for SAR-based toxicological assessments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

Data mining reveals a network of early-response genes as a consensus signature of drug-induced in vitro and in vivo toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW058

21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFW058

1 reference

6 September 2017

1 reference