(Q38799987)

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BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma cells

scientific article published on 25 January 2016

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scholarly article

1 reference

Europe PubMed Central

6 September 2017

BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma cells (English)

1 reference

Europe PubMed Central

6 September 2017

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Joydeep Bhadury

2

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26804177%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

author name string

S V Muralidharan

1

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11 June 2020

L M Nilsson

3

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Europe PubMed Central

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11 June 2020

L C Green

4

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11 June 2020

K G McLure

5

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11 June 2020

J A Nilsson

6

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11 June 2020

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publication date

25 January 2016

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6 September 2017

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11 June 2020

35

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11 June 2020

4689-4697

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11 June 2020

36

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11 June 2020

https://scigraph.springernature.com/pub.10.1038/onc.2015.521

0 references

BET domain co-regulators in obesity, inflammation and cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Selective inhibition of tumor oncogenes by disruption of super-enhancers

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

BET bromodomain proteins are required for glioblastoma cell proliferation.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Therapeutic targeting of c-Myc in T-cell acute lymphoblastic leukemia, T-ALL

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

BET bromodomain inhibition of MYC-amplified medulloblastoma.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Targeting Myc in KSHV-associated primary effusion lymphoma with BET bromodomain inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Targeting MYCN in neuroblastoma by BET bromodomain inhibition

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Androgen receptor promotes ligand-independent prostate cancer progression through c-Myc upregulation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Inhibition of BET bromodomain targets genetically diverse glioblastoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Targeting MYC dependence in cancer by inhibiting BET bromodomains

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Transcriptional pause, arrest and termination sites for RNA polymerase II in mammalian N- and c-myc genes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Intrinsic sites of transcription termination and pausing in the c-myc gene

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Highly active combination of BRD4 antagonist and histone deacetylase inhibitor against human acute myelogenous leukemia cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Cell cycle activation by c-myc in a burkitt lymphoma model cell line.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Identification of tumorigenic and therapeutically actionable mutations in transplantable mouse tumor cells by exome sequencing

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Replication stress and cancer: it takes two to tango.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Efficacy of CHK inhibitors as single agents in MYC-driven lymphoma cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Therapeutic implications for the induced levels of Chk1 in Myc-expressing cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Myc suppression of Nfkb2 accelerates lymphomagenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

The IKK2/NF-{kappa}B pathway suppresses MYC-induced lymphomagenesis.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Nfkb 1 is dispensable for Myc-induced lymphomagenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

p62 at the crossroads of autophagy, apoptosis, and cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Chromatin reader Brd4 functions in Ig class switching as a repair complex adaptor of nonhomologous end-joining

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Combining radiation and immunotherapy: a new systemic therapy for solid tumors?

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Negative regulation of the mammalian UV response by Myc through association with Miz-1

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.521

21 January 2018

RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F

1 reference

https://pubmed.ncbi.nlm.nih.gov/26804177

12 December 2020

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