(Q39089080)

English

A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.

scientific article published on October 2013

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24085192%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24085192%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24085192%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

author name string

Frida Gustafsson

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24085192%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Alison J Foster

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24085192%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Sunil Sarda

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24085192%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Matthew H Bridgland-Taylor

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24085192%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

publication date

1 October 2013

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24085192%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Toxicological Sciences

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24085192%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

137

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24085192%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

189-211

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24085192%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24085192%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Production of DNA strand breaks by N-nitrosodimethylamine and 2-amino-3-methylimidazo[4,5-f]quinoline in THLE cells expressing human CYP isoenzymes and inhibition by sulforaphane

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

High Expression of Human CYP2C in Immortalized Human Liver Epithelial Cells.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

Development of a whole-cell screening system for evaluation of the human CYP1A2-mediated metabolism

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

New technologies and screening strategies for hepatotoxicity: use of in vitro models

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

The significance of mitochondrial toxicity testing in drug development

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

Bioactivation of the cannabinoid receptor antagonist rimonabant to a cytotoxic iminium ion metabolite.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

Cell based approaches for evaluation of drug-induced liver injury.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

Functional consequences of active hepatic uptake on cytochrome P450 inhibition in rat and human hepatocytes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

The mechanism of bioactivation and antigen formation of amodiaquine in the rat

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

Development of a highly sensitive cytotoxicity assay system for CYP3A4-mediated metabolic activation

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

Identification of a reactive metabolite of terbinafine: insights into terbinafine-induced hepatotoxicity

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

CYP2C9-mediated metabolic activation of losartan detected by a highly sensitive cell-based screening assay

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent binding.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

Genetic and molecular factors in drug-induced liver injury: a review.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

Managing the challenge of chemically reactive metabolites in drug development.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

Simian virus 40 large tumor antigen-immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

Hepatotoxicity of ketoconazole in Sprague-Dawley rats: glutathione depletion, flavin-containing monooxygenases-mediated bioactivation and hepatic covalent binding

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

Animal models of idiosyncratic drug-induced liver injury--current status

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

Characterization of THLE-cytochrome P450 (P450) cell lines: gene expression background and relationship to P450-enzyme activity.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

An in vitro approach to detect metabolite toxicity due to CYP3A4-dependent bioactivation of xenobiotics

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

The role of CYP3A4 in amiodarone-associated toxicity on HepG2 cells.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

FDA-approved drug labeling for the study of drug-induced liver injury

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT223

21 January 2018

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q39089080&oldid=1449855676"