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Transcriptional Addiction in Cancer.
scientific article published on February 2017
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Europe PubMed Central
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5308559
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2 April 2020
title
Transcriptional Addiction in Cancer
(English)
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Europe PubMed Central
PMCID
5308559
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28187285%20AND%20SRC:MED&resulttype=core&format=json
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2 April 2020
author
Denes Hnisz
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2
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Europe PubMed Central
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5308559
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2 April 2020
Richard A. Young
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3
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Europe PubMed Central
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5308559
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2 April 2020
author name string
James E Bradner
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1
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language of work or name
English
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publication date
1 February 2017
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2 April 2020
published in
Cell
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5308559
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volume
168
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5308559
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2 April 2020
page(s)
629-643
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2 April 2020
issue
4
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2 April 2020
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Retinoic acid and arsenic trioxide for acute promyelocytic leukemia
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Chromatin insulators: linking genome organization to cellular function
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Mechanisms and models of somatic cell reprogramming
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Dysregulation of the basal RNA polymerase transcription apparatus in cancer
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Selective inhibition of tumor oncogenes by disruption of super-enhancers
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Master transcription factors and mediator establish super-enhancers at key cell identity genes
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Lessons from the cancer genome
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Cancer genome landscapes
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Transcriptional regulation and its misregulation in disease.
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22 June 2018
Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
The hierarchy of the 3D genome
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Targeting MYCN in neuroblastoma by BET bromodomain inhibition
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Activating RNAs associate with Mediator to enhance chromatin architecture and transcription
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
A blueprint for engineering cell fate: current technologies to reprogram cell identity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Transcriptional amplification in tumor cells with elevated c-Myc.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Molecular roadblocks for cellular reprogramming
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
An integrated encyclopedia of DNA elements in the human genome
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Lineage conversion methodologies meet the reprogramming toolbox
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
Transcription factors: from enhancer binding to developmental control
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
Induced pluripotent stem cells: past, present, and future
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Ubiquitin and proteasomes in transcription
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
Master transcription factors determine cell-type-specific responses to TGF-β signaling
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
BET bromodomain inhibition as a therapeutic strategy to target c-Myc
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Enhancer function: new insights into the regulation of tissue-specific gene expression
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Functional and mechanistic diversity of distal transcription enhancers
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Glucocorticoid use in acute lymphoblastic leukaemia
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
Selective inhibition of BET bromodomains
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
Mediator and cohesin connect gene expression and chromatin architecture
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
p53 Research: the past thirty years and the next thirty years.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
c-Myc regulates transcriptional pause release
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
The landscape of somatic copy-number alteration across human cancers
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Forcing cells to change lineages
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Direct inhibition of the NOTCH transcription factor complex
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Histones: annotating chromatin
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
The cancer genome
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Linking somatic genetic alterations in cancer to therapeutics
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
A census of human transcription factors: function, expression and evolution
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
H3K79 methylation profiles define murine and human MLL-AF4 leukemias
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
Modelling Myc inhibition as a cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Acute promyelocytic leukemia: from highly fatal to highly curable
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
Chromatin modifications and their function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
Transcription factors as targets for cancer therapy
1 reference
stated in
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Transcriptional regulation: Kamikaze activators
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Reversible tumorigenesis by MYC in hematopoietic lineages
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
retrieved
22 June 2018
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Multiple new phenotypes induced in and 3T3 cells treated with 5-azacytidine
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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22 June 2018
Methylation-dependent and -independent genomic targeting principles of the MBD protein family.
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5308559
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21 August 2018
15/17 translocation, a consistent chromosomal change in acute promyelocytic leukaemia
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/28187285
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Sustained loss of a neoplastic phenotype by brief inactivation of MYC
1 reference
stated in
PubMed
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https://pubmed.ncbi.nlm.nih.gov/28187285
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CELL.2016.12.013
1 reference
stated in
Europe PubMed Central
PMCID
5308559
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28187285%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
PMCID
5308559
1 reference
stated in
Europe PubMed Central
PMCID
5308559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28187285%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
PubMed ID
28187285
1 reference
stated in
Europe PubMed Central
PMCID
5308559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28187285%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
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