(Q39141872)

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Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts

scientific article published on 8 November 2015

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Europe PubMed Central

PMC publication ID

9 September 2017

Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts (English)

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Europe PubMed Central

PMC publication ID

9 September 2017

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Huynh-Hoa Bui

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9 September 2017

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Sebastien A Burel

1

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9 September 2017

Christopher E Hart

2

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9 September 2017

Patrick Cauntay

3

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9 September 2017

Jill Hsiao

4

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9 September 2017

Todd Machemer

5

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9 September 2017

Melanie Katz

6

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9 September 2017

Andy Watt

7

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9 September 2017

Husam Younis

9

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9 September 2017

Mahyar Sabripour

10

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9 September 2017

Susan M Freier

11

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9 September 2017

Gene Hung

12

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9 September 2017

Amy Dan

13

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T P Prakash

14

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Punit P Seth

15

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9 September 2017

Eric E Swayze

16

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9 September 2017

C Frank Bennett

17

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Stanley T Crooke

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Scott P Henry

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9 September 2017

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8 November 2015

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9 September 2017

Nucleic Acids Research

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9 September 2017

44

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9 September 2017

5

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9 September 2017

2093-2109

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9 September 2017

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Creative Commons Attribution-NonCommercial 4.0 International

11 November 2016

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April 2022 Public Data File from Crossref

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1 reference

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Sequence motifs associated with hepatotoxicity of locked nucleic acid--modified antisense oligonucleotides.

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Human RNase H1 discriminates between subtle variations in the structure of the heteroduplex substrate

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The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysis.

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The influence of locked nucleic acid residues on the thermodynamic properties of 2'-O-methyl RNA/RNA heteroduplexes

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Expression profiling reveals off-target gene regulation by RNAi

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The clinical experience of antisense therapy to ICAM-1 in Crohn's disease

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Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a 4-week study in CD-1 mice

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1 reference

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inferred from PubMed ID database lookup

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10.1093/NAR/GKV1210

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 September 2017

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