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Mechanisms and consequences of Jak-STAT signaling in the immune system.
scientific article published on March 2017
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Europe PubMed Central
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28323260
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28323260%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 March 2020
title
Mechanisms and consequences of Jak-STAT signaling in the immune system
(English)
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Europe PubMed Central
PubMed publication ID
28323260
reference URL
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retrieved
13 March 2020
author
Alejandro Villarino
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1
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Europe PubMed Central
PubMed publication ID
28323260
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28323260%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 March 2020
Yuka Kanno
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2
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Europe PubMed Central
PubMed publication ID
28323260
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13 March 2020
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John J O'Shea
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Europe PubMed Central
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28323260
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28323260%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 March 2020
language of work or name
English
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1 March 2017
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Europe PubMed Central
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28323260
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retrieved
13 March 2020
published in
Nature Immunology
1 reference
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Europe PubMed Central
PubMed publication ID
28323260
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28323260%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 March 2020
volume
18
1 reference
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Europe PubMed Central
PubMed publication ID
28323260
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28323260%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 March 2020
issue
4
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Europe PubMed Central
PubMed publication ID
28323260
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retrieved
13 March 2020
page(s)
374-384
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Europe PubMed Central
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28323260
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retrieved
13 March 2020
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Potent efficacy of combined PI3K/mTOR and JAK or ABL inhibition in murine xenograft models of Ph-like acute lymphoblastic leukemia
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JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors
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JAK2/STAT5 inhibition circumvents resistance to PI3K/mTOR blockade: a rationale for cotargeting these pathways in metastatic breast cancer
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Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8(+) T Cells
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Parsing the Interferon Transcriptional Network and Its Disease Associations
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Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy
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Cooperating JAK1 and JAK3 mutants increase resistance to JAK inhibitors
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Glycosylation-Dependent IFN-γR Partitioning in Lipid and Actin Nanodomains Is Critical for JAK Activation.
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The Structural Basis for Class II Cytokine Receptor Recognition by JAK1
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Structure of the unphosphorylated STAT5a dimer
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Structural basis for DNA recognition by STAT6.
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7 January 2021
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GAS elements: a few nucleotides with a major impact on cytokine-induced gene expression.
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7 January 2021
based on heuristic
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Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing
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7 January 2021
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Transcriptional enhancers: from properties to genome-wide predictions
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7 January 2021
based on heuristic
inferred from DOI database lookup
STATs shape the active enhancer landscape of T cell populations
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7 January 2021
based on heuristic
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Latent enhancers activated by stimulation in differentiated cells
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7 January 2021
based on heuristic
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Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling
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7 January 2021
based on heuristic
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Epigenetic control of T-helper-cell differentiation
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7 January 2021
based on heuristic
inferred from DOI database lookup
Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation
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7 January 2021
based on heuristic
inferred from DOI database lookup
Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis.
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7 January 2021
based on heuristic
inferred from DOI database lookup
IFN-γ Induces Histone 3 Lysine 27 Trimethylation in a Small Subset of Promoters to Stably Silence Gene Expression in Human Macrophages.
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Mammary-specific gene activation is defined by progressive recruitment of STAT5 during pregnancy and the establishment of H3K4me3 marks
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha
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7 January 2021
based on heuristic
inferred from DOI database lookup
Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2
1 reference
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reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3
1 reference
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https://api.crossref.org/works/10.1038%2FNI.3691
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7 January 2021
based on heuristic
inferred from DOI database lookup
Functional interactions between Stat5 and the glucocorticoid receptor
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression
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7 January 2021
based on heuristic
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Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
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7 January 2021
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A validated regulatory network for Th17 cell specification
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7 January 2021
based on heuristic
inferred from DOI database lookup
BATF-JUN is critical for IRF4-mediated transcription in T cells
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals
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7 January 2021
based on heuristic
inferred from DOI database lookup
The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
FoxP3 acts as a cotranscription factor with STAT3 in tumor-induced regulatory T cells.
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
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7 January 2021
based on heuristic
inferred from DOI database lookup
The significance of tetramerization in promoter recruitment by Stat5.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
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7 January 2021
based on heuristic
inferred from DOI database lookup
Hierarchy within the mammary STAT5-driven Wap super-enhancer.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
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7 January 2021
based on heuristic
inferred from DOI database lookup
Comprehensive meta-analysis of Signal Transducers and Activators of Transcription (STAT) genomic binding patterns discerns cell-specific cis-regulatory modules
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
STAT4 is required for interleukin-12-induced chromatin remodeling of the CD25 locus.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
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7 January 2021
based on heuristic
inferred from DOI database lookup
Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes
1 reference
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7 January 2021
based on heuristic
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An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction
1 reference
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https://api.crossref.org/works/10.1038%2FNI.3691
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7 January 2021
based on heuristic
inferred from DOI database lookup
Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
STAT5 is a potent negative regulator of TFH cell differentiation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
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7 January 2021
based on heuristic
inferred from DOI database lookup
Role of Blimp-1 in programing Th effector cells into IL-10 producers
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
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7 January 2021
based on heuristic
inferred from DOI database lookup
The Stat3/GR interaction code: predictive value of direct/indirect DNA recruitment for transcription outcome
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
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7 January 2021
based on heuristic
inferred from DOI database lookup
Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
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7 January 2021
based on heuristic
inferred from DOI database lookup
Components of a Stat recognition code: evidence for two layers of molecular selectivity
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https://api.crossref.org/works/10.1038%2FNI.3691
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mutational switch of an IL-6 response to an interferon-gamma-like response
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https://api.crossref.org/works/10.1038%2FNI.3691
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7 January 2021
based on heuristic
inferred from DOI database lookup
Alternative activation of STAT1 and STAT3 in response to interferon-gamma
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https://api.crossref.org/works/10.1038%2FNI.3691
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7 January 2021
based on heuristic
inferred from DOI database lookup
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.
1 reference
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https://api.crossref.org/works/10.1038%2FNI.3691
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7 January 2021
based on heuristic
inferred from DOI database lookup
Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
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7 January 2021
based on heuristic
inferred from DOI database lookup
The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells
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reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
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7 January 2021
based on heuristic
inferred from DOI database lookup
STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
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7 January 2021
based on heuristic
inferred from DOI database lookup
IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
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7 January 2021
based on heuristic
inferred from DOI database lookup
Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The interleukin-4 receptor activates STAT5 by a mechanism that relies upon common gamma-chain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytokine signaling modules in inflammatory responses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+ T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of JAK-STAT signalling in the immune system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein tyrosine phosphatases as wardens of STAT signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SOCS proteins, cytokine signalling and immune regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SOCS3 negatively regulates IL-6 signaling in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SOCS3 regulates the plasticity of gp130 signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-{gamma} and IL-17A production
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The functions of signal transducers and activators of transcriptions 1 and 3 as cytokine-inducible proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An autoregulatory enhancer controls mammary-specific STAT5 functions.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Integrating non-coding RNAs in JAK-STAT regulatory networks
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PDLIM2 inhibits T helper 17 cell development and granulomatous inflammation through degradation of STAT3.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Grail controls Th2 cell development by targeting STAT6 for degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of Jak/STAT signaling in immunity and disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
STAT heterodimers in immunity: A mixed message or a unique signal?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of the amino-terminal protein interaction domain of STAT-4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
STAT1-cooperative DNA binding distinguishes type 1 from type 2 interferon signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytokine-induced megakaryocytic differentiation is regulated by genome-wide loss of a uSTAT transcriptional program.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Function of mitochondrial Stat3 in cellular respiration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
STAT3-driven transcription depends upon the dimethylation of K49 by EZH2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of type I interferon responses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A role for the ITAM signaling module in specifying cytokine-receptor functions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The adaptor TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating signaling via the receptor for IL-2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Encoding of a homolog of the IFN-gamma receptor by myxoma virus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A Tyr/Ser protein phosphatase encoded by vaccinia virus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of IFN-gamma signaling by an Epstein-Barr virus immediate-early protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Toxoplasma gondii TgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ-mediated host defenses.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inborn errors of human JAKs and STATs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The STAT5b Pathway Defect and Autoimmunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Janus kinase deregulation in leukemia and lymphoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Somatic STAT3 mutations in large granular lymphocytic leukemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activating STAT6 mutations in follicular lymphoma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK-STAT pathway in Sézary syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
STAT1-Activating Cytokines Limit Th17 Responses through Both T-bet–Dependent and –Independent Mechanisms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The transcription factor STAT3 is required for T helper 2 cell development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
STAT3 is required for Flt3L-dependent dendritic cell differentiation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A critical role for Stat3 signaling in immune tolerance
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stat5a/b are essential for normal lymphoid development and differentiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nonredundant roles for Stat5a/b in directly regulating Foxp3
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Disparate roles for STAT5 in primary and secondary CTL responses.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of the Stat1 transactivation domain is required for full-fledged IFN-gamma-dependent innate immunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In search of magic bullets: the golden age of immunotherapeutics.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-2: Biology, Design and Application
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
New insights into the mechanisms of hematopoietic cell transformation by activated receptor tyrosine kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nucleic acid-based approaches to STAT inhibition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Therapeutic modulators of STAT signalling for human diseases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI.3691
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential cytokine sensitivities of STAT5-dependent enhancers rely on Stat5 autoregulation.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28323260
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28323260
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Immunocytokines for cancer treatment: past, present and future
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28323260
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/NI.3691
1 reference
stated in
Europe PubMed Central
PubMed publication ID
28323260
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28323260%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 March 2020
PubMed publication ID
28323260
1 reference
stated in
Europe PubMed Central
PubMed publication ID
28323260
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28323260%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 March 2020
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