(Q39579728)

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Identification of PUMA as an estrogen target gene that mediates the apoptotic response to tamoxifen in human breast cancer cells and predicts patient outcome and tamoxifen responsiveness in breast cancer.

scientific article published on 7 March 2011

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scholarly article

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24 January 2020

Identification of PUMA as an estrogen target gene that mediates the apoptotic response to tamoxifen in human breast cancer cells and predicts patient outcome and tamoxifen responsiveness in breast cancer (English)

1 reference

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24 January 2020

apoptotic process

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based on heuristic

inferred from title

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based on heuristic

inferred from title

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24 January 2020

Rachael A McCloy

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author name string

C G Roberts

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24 January 2020

S A O'Toole

3

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24 January 2020

C M McNeil

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24 January 2020

G M Lehrbach

5

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24 January 2020

P Tobelmann

7

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24 January 2020

E A Musgrove

9

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24 January 2020

R L Sutherland

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language of work or name

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publication date

7 March 2011

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24 January 2020

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24 January 2020

3186-3197

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24 January 2020

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24 January 2020

https://scigraph.springernature.com/pub.10.1038/onc.2011.36

0 references

BAG-1 overexpression attenuates luminal apoptosis in MCF-10A mammary epithelial cells through enhanced RAF-1 activation.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

Cell cycle machinery: links with genesis and treatment of breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

Live or let die: oestrogen regulation of survival signalling in endocrine response

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

A novel plant toxin, persin, with in vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

Bad expression predicts outcome in patients treated with tamoxifen.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

Genome-wide analysis of estrogen receptor binding sites

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

Neoadjuvant comparisons of aromatase inhibitors and tamoxifen: pretreatment determinants of response and on-treatment effect

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

Stromal gene expression predicts clinical outcome in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

Rational management of endocrine resistance in breast cancer: a comprehensive review of estrogen receptor biology, treatment options, and future directions.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

A century of deciphering the control mechanisms of sex steroid action in breast and prostate cancer: the origins of targeted therapy and chemoprevention

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

BAG-1 predicts patient outcome and tamoxifen responsiveness in ER-positive invasive ductal carcinoma of the breast.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

Identification of functional networks of estrogen- and c-Myc-responsive genes and their relationship to response to tamoxifen therapy in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

Biological determinants of endocrine resistance in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

PUMA, a novel proapoptotic gene, is induced by p53

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

The HER4/4ICD estrogen receptor coactivator and BH3-only protein is an effector of tamoxifen-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

17beta-estradiol inhibits apoptosis in MCF-7 cells, inducing bcl-2 expression via two estrogen-responsive elements present in the coding sequence.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

Tumour Fas ligand:Fas ratio greater than 1 is an independent marker of relative resistance to tamoxifen therapy in hormone receptor positive breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

Mutations in p53 as potential molecular markers for human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

SERMs for the treatment and prevention of breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

A gene-expression signature as a predictor of survival in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

PUMA induces the rapid apoptosis of colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

The transcriptional targets of p53 in apoptosis control

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

PUMA, a potent killer with or without p53

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

21 January 2018

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

31 March 2020

PUMA expression is significantly reduced in human cutaneous melanomas

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

31 March 2020

Apoptosis. p53 and PUMA: a deadly duo

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.36

31 March 2020

Identifiers

10.1038/ONC.2011.36

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21383694%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference

Europe PubMed Central

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24 January 2020

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