(Q39620587)

English

Decitabine-induced apoptosis is derived by Puma and Noxa induction in chronic myeloid leukemia cell line as well as in PBL and is potentiated by SAHA.

scientific article published on 14 December 2010

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1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Decitabine-induced apoptosis is derived by Puma and Noxa induction in chronic myeloid leukemia cell line as well as in PBL and is potentiated by SAHA. (English)

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

chronic myeloid leukemia

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1 reference

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author name string

Barbora Brodská

1

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Petra Otevřelová

2

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Aleš Holoubek

3

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

publication date

14 December 2010

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Molecular and Cellular Biochemistry

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Europe PubMed Central

PubMed publication ID

13 September 2017

350

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

1-2

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

71-80

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Epigenetic therapy of leukemia: An update

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5-azacitidine prolongs overall survival in patients with myelodysplastic syndrome--a systematic review and meta-analysis

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p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage.

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5-Aza-2'-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation.

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An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment

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p21Waf1/Cip1 plays a critical role in modulating senescence through changes of DNA methylation

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Methylation silencing of the Apaf-1 gene in acute leukemia

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Demethylating agent 5-aza-2'-deoxycytidine enhances susceptibility of bladder transitional cell carcinoma to Cisplatin

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5-Aza-2'-deoxycytidine restores proapoptotic function of p53 in cancer cells resistant to p53-induced apoptosis.

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Decitabine activates specific caspases downstream of p73 in myeloid leukemia

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Decitabine induces cell cycle arrest at the G1 phase via p21(WAF1) and the G2/M phase via the p38 MAP kinase pathway

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Mechanisms of resistance to 5-aza-2'-deoxycytidine in human cancer cell lines

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Histone deacetylase inhibitors as anti-neoplastic agents.

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Three epigenetic drugs up-regulate homeobox gene Rhox5 in cancer cells through overlapping and distinct molecular mechanisms

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Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells

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c-Myc overexpression sensitizes Bim-mediated Bax activation for apoptosis induced by histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through regulating Bcl-2/Bcl-xL expression

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Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in mantle cell lymphoma

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Cell cycle and apoptotic effects of SAHA are regulated by the cellular microenvironment in HCT116 multicellular tumour spheroids.

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Combined effects of sulindac and suberoylanilide hydroxamic acid on apoptosis induction in human lung cancer cells

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Suberoylanilide hydroxamic acid (SAHA) at subtoxic concentrations increases the adhesivity of human leukemic cells to fibronectin.

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Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma.

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Variations in c-Myc and p21WAF1 expression protect normal peripheral blood lymphocytes against BimEL-mediated cell death.

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Identification of candidate tumor suppressor genes inactivated by promoter methylation in melanoma

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Repression of induced apoptosis in the 2-cell bovine embryo involves DNA methylation and histone deacetylation

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HDAC inhibitors act with 5-aza-2'-deoxycytidine to inhibit cell proliferation by suppressing removal of incorporated abases in lung cancer cells

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Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice

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IGF-1 suppresses Bim expression in multiple myeloma via epigenetic and posttranslational mechanisms.

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In vitro basis for treatment with hypomethylating agents and histone deacetylase inhibitors: can epigenetic changes be used to monitor treatment?

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The combination effect of sodium butyrate and 5-Aza-2'-deoxycytidine on radiosensitivity in RKO colorectal cancer and MCF-7 breast cancer cell lines

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Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo

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Actinomycin D upregulates proapoptotic protein Puma and downregulates Bcl-2 mRNA in normal peripheral blood lymphocytes

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Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosis

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Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members

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DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication

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Blockade of MEK signaling potentiates 5-Aza-2'-deoxycytidine-induced apoptosis and upregulation of p21(waf1) in acute myelogenous leukemia cells.

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The proteasome: a novel target for cancer chemotherapy

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Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).

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5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells.

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DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.

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Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis

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Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine

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MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

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Myeloid cell leukemia-1 as a therapeutic target

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

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Caspase-dependent apoptosis and -independent poly(ADP-ribose) polymerase cleavage induced by transforming growth factor beta1.

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1 reference

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Identifiers

10.1007/S11010-010-0683-3

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

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