(Q39760907)

14 September 2017

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title

Biological and biochemical properties of new anticancer folate antagonists (English)

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14 September 2017

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D W Fry

1

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PubMed ID

3549036

14 September 2017

R C Jackson

series ordinal

2

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14 September 2017

1 January 1987

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Cancer and Metastasis Reviews

14 September 2017

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14 September 2017

5

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14 September 2017

251-270

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14 September 2017

3

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https://scigraph.springernature.com/pub.10.1007/bf00047000

14 September 2017

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Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies.

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DDMP (2,4-diamino-5-(3',4'-dichlorophenyl)-methylpyrimidine).

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Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-(( 2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino) benzoyl)-L-glutamic acid (CB3717), on human lymphoblastoid cells

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12 December 2020

Biochemical and chemotherapeutic studies on 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine (BW 301U), a novel lipid-soluble inhibitor of dihydrofolate reductase

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Pharmacology and toxicity of a potent "nonclassical" 2,4-diamino quinazoline folate antagonist, trimetrexate, in normal dogs.

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Antitumor properties of a new folate analog, 10-deaza-aminopterin, in mice

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Paradoxical effect of BW 301U, a lipophilic antifolate, on methotrexate-inhibitable deoxyuridine incorporation by human hematopoietic cells

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New folate analogs of the 10-deaza-aminopterin series: markedly increased antitumor activity of the 10-ethyl analog compared to the parent compound and methotrexate against some human tumor xenografts in nude mice.

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Cytotoxic effects of folate antagonists against methotrexate-resistant human leukemic lymphoblast CCRF-CEM cell lines

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A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice

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Overcoming methotrexate resistance by a lipophilic antifolate (BW 301U): from theory to models to practice

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Preclinical biochemical pharmacology and toxicology of piritrexim, a lipophilic inhibitor of dihydrofolate reductase.

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Comparison of leucovorin protection from variety of antifolates in human lymphoid cell lines.

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12 December 2020

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12 December 2020

Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate

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12 December 2020

Fluorometric high-performance liquid chromatographic analysis of 10-deazaaminopterin, 10-ethyl-10-deazaaminopterin, and known metabolites

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12 December 2020

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12 December 2020

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12 December 2020

Uptake and efficacy of trimetrexate (TMQ, 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl] quinazoline), a non-classical antifolate in methotrexate-resistant leukemia cells in vitro

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12 December 2020

New folate analogs of the 10-deaza-aminopterin series. Further evidence for markedly increased antitumor efficacy compared with methotrexate in ascitic and solid murine tumor models

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12 December 2020

Inhibition of metabolism of the 'nonclassical' antifolate, trimetrexate (2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline) by drugs containing an imidazole moiety

1 reference

12 December 2020

Activity of the new antifolate N10-propargyl-5,8-dideazafolate and its polyglutamates against human dihydrofolate reductase, human thymidylate synthetase, and KB cells containing different levels of dihydrofolate reductase.

1 reference

12 December 2020

Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine

1 reference

12 December 2020

Biochemical and pharmacologic properties of a new folate analog, 10-deaza-aminopterin, in mice

1 reference

12 December 2020

New folate analogs of the 10-deaza-aminopterin series. Basis for structural design and biochemical and pharmacologic properties

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12 December 2020

Inhibitory action of 10-deazaaminopterins and their polyglutamates on human thymidylate synthase

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12 December 2020

Identifiers

DOI

10.1007/BF00047000

1 reference

14 September 2017

1 reference

PubMed ID

3549036