(Q39773875)

English

Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo.

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19917641%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo (English)

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19917641%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

phosphorylation

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Daniel R McMasters

10

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12 February 2020

author name string

Denise M Kenski

1

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12 February 2020

Abby J Cooper

2

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12 February 2020

Jenny J Li

3

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12 February 2020

Aarron T Willingham

4

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12 February 2020

Henry J Haringsma

5

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12 February 2020

Tracy A Young

6

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12 February 2020

Nelly A Kuklin

7

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12 February 2020

Jeffrey J Jones

8

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12 February 2020

Mark T Cancilla

9

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12 February 2020

Melina Mathur

11

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12 February 2020

Alan B Sachs

12

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12 February 2020

W Michael Flanagan

13

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12 February 2020

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16 November 2009

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12 February 2020

Nucleic Acids Research

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12 February 2020

38

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12 February 2020

660-671

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12 February 2020

2

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12 February 2020

describes a project that uses

1 reference

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2811019/fullTextXML

based on heuristic

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C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

MicroRNA-like off-target transcript regulation by siRNAs is species specific.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

Structure of the guide-strand-containing argonaute silencing complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

Comparison of multiple DNA dyes for real-time PCR: effects of dye concentration and sequence composition on DNA amplification and melting temperature.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

Interfering with disease: a progress report on siRNA-based therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

2'-fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

RNA learns from antisense

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

A potential protein-RNA recognition event along the RISC-loading pathway from the structure of A. aeolicus Argonaute with externally bound siRNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

A brief history of RNAi: the silence of the genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

Real-time quantification of microRNAs by stem-loop RT-PCR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

Purified Argonaute2 and an siRNA form recombinant human RISC

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

In vivo activity of nuclease-resistant siRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

siRNAs: applications in functional genomics and potential as therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

Asymmetry in the assembly of the RNAi enzyme complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

RNA interference is mediated by 21- and 22-nucleotide RNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

22 September 2017

Identification of essential genes in cultured mammalian cells using small interfering RNAs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

25 September 2017

Binding and cleavage specificities of human Argonaute2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

17 June 2018

Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

17 June 2018

Inhibition of MDR1 expression with altritol-modified siRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

17 June 2018

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

17 June 2018

siRNA function in RNAi: a chemical modification analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

17 June 2018

Unlocked nucleic acid (UNA) and UNA derivatives: thermal denaturation studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

20 August 2018

Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

20 August 2018

Efficient RNase H-directed cleavage of RNA promoted by antisense DNA or 2'F-ANA constructs containing acyclic nucleotide inserts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

20 August 2018

Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

20 August 2018

Short 5'-phosphorylated double-stranded RNAs induce RNA interference in Drosophila.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811019

20 August 2018

2'-O-methyl-modified RNAs act as TLR7 antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/19917641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of Abasic Locked Nucleic Acid and Twoseco-LNA Derivatives and Evaluation of Their Hybridization Properties Compared with Their More Flexible DNA Counterparts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19917641

12 December 2020

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inferred from PubMed ID database lookup

Synthesis and evaluation of oligodeoxynucleotides containing acyclic nucleosides: Introduction of three novel analogues and a summary

1 reference

https://pubmed.ncbi.nlm.nih.gov/19917641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/NAR/GKP913

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12 February 2020

1 reference

Europe PubMed Central

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12 February 2020

1 reference

Europe PubMed Central

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12 February 2020

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