(Q39798829)

English

TheAhLocus: Genetic Regulation of the Metabolism of Carcinogens, Drugs, and Other Environmental Chemicals by Cytochrome P-450-Mediated Monooxygenase

scientific article published on January 1, 1979

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

1 reference

Europe PubMed Central

The Ah locus: genetic regulation of the metabolism of carcinogens, drugs, and other environmental chemicals by cytochrome P-450-mediated monooxygenases (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

TheAhLocus: Genetic Regulation of the Metabolism of Carcinogens, Drugs, and Other Environmental Chemicals by Cytochrome P-450-Mediated Monooxygenase (English)

1 reference

10.3109/10409237909105427

https://api.crossref.org/works/10.3109/10409237909105427

12 April 2023

author name string

D. W. Nebert

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A378536

12 April 2023

N. M. Jensen

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A378536

12 April 2023

language of work or name

1 reference

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publication date

1 January 1979

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

full work available at URL

http://www.tandfonline.com/doi/pdf/10.3109/10409237909105427

1 reference

10.3109/10409237909105427

https://api.crossref.org/works/10.3109/10409237909105427

12 April 2023

CRC critical reviews in biochemistry

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

401-437

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Arene oxides: a new aspect of drug metabolism

1 reference

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21 January 2018

Chemical carcinogenesis

1 reference

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21 January 2018

Enzymic reduction of aromatic hydrocarbon epoxides by the microsomal fraction of rat liver

1 reference

https://api.crossref.org/works/10.3109%2F10409237909105427

21 January 2018

Evidence for the involvement of cytochrome P-450 in reduction of benzo(a)pyrene 4,5-oxide by rat liver microsomes

1 reference

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21 January 2018

Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse

1 reference

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21 January 2018

Genetic aspects of toxicity during development

1 reference

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21 January 2018

Genetic association of increases in naphthalene, acetanilide, and biphenyl hydroxylations with inducible aryl hydrocarbon hydroxylase in mice

1 reference

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21 January 2018

The stimulation of hydroxylation by carcinogenic and non-carcinogenic compounds.

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21 January 2018

Influence of inducers and inhibitors on the hydroxylation pattern of n -hexane in rat liver microsomes

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21 January 2018

Effects of Inducers and Epoxide Hydrase on the Metabolism of Benzo[ a ]pyrene by Liver Microsomes and a Reconstituted System: Analysis by High Pressure Liquid Chromatography

1 reference

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21 January 2018

Arene oxides and the NIH shift: the metabolism, toxicity and carcinogenicity of aromatic compounds.

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21 January 2018

A rapid assay for epoxide hydratase activity with benzo (a)pyrene 4,5-(K-region)-oxide as substrate

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21 January 2018

Genetic expression of aryl hydrocarbon hydroxylase induction. VI. Control of other aromatic hydrocarbon-inducible mono-oxygenase activities at or near the same genetic locus

1 reference

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21 January 2018

Phenolic benzo(a)pyrene metabolites are mutagens

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21 January 2018

Effects of microsomal enzyme inducers in vivo and inhibitors in vitro on the covalent binding of benzo[a]pyrene metabolites to DNA catalyzed by liver microsomes from genetically responsive and nonresponsive mice

1 reference

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21 January 2018

Benzo[a]pyrene 7,8-dihydrodiol is more carcinogenic than benzo[a]pyrene in newborn mice

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21 January 2018

Carcinogenicity of benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides on mouse skin

1 reference

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21 January 2018

Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells

1 reference

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21 January 2018

Mutagenicity of non-K-region diols and diol-epoxides of benz(a)anthracene and benzo(a)pyrene in S. typhimurium TA 100

1 reference

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21 January 2018

Birth defects and aplastic anemia: differences in polycyclic hydrocarbon toxicity associated with the Ah locus

1 reference

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21 January 2018

The genetic basis of susceptibility to leukemia induction in mice by 3-methylcholanthrene applied percutaneously

1 reference

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21 January 2018

Mutagenic and cytotoxic activity of benzol[a]pyrene 4,5-, 7,8-, and 9,10-oxides and the six corresponding phenols

1 reference

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21 January 2018

β-Glucuronidase Catalyzed Hydrolysis of Benzo[ a ]pyrene-3-Glucuronide and Binding to DNA

1 reference

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21 January 2018

Genetic control of glucuronidase induction in mice

1 reference

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21 January 2018

Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test

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21 January 2018

Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals

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21 January 2018

Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion

1 reference

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21 January 2018

Conversion of naphthalene to trans-naphthalene dihydrodiol: Evidence for the presence of a coupled aryl monooxygenase-epoxide hydrase system in hepatic microsomes

1 reference

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21 January 2018

Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters.

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21 January 2018

Lens Cataract Formation and Reversible Alteration in Crystallin Synthesis in Cultured Lenses

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21 January 2018

α-Crystallin. The isolation and characterization of distinct macromolecular fractions

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21 January 2018

Absence of low-molecular-weight alpha crystallin in nuclear region of old human lenses

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21 January 2018

THE NATURE OF THE OCULAR LESIONS PRODUCED EXPERIMENTALLY BY NAPHTHALENE.

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21 January 2018

The metabolism of naphthalene and its toxic effect on the eye.

1 reference

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21 January 2018

Ah Locus: Genetic Differences in Susceptibility to Cataracts Induced by Acetaminophen

1 reference

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21 January 2018

Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma.

1 reference

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21 January 2018

Assignment of a locus required for flavoprotein-linked monooxygenase expression to human chromosome 2

1 reference

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21 January 2018

Independent regulation of two types of aryl hydrocarbon (benzo(a)pyrene) hydroxylase in mammalian cells

1 reference

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21 January 2018

The molecular genetics of mammalian glucuronidase

1 reference

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21 January 2018

Relationships between aryl hydrocarbon hydroxylase inducibility and sensitivity to chemically induced subcutaneous sarcomas in various strains of mice

1 reference

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21 January 2018

Evidence of a Genetic Relationship Between Susceptibility to 3-Methylcholanthrene-Induced Subcutaneous Tumors and Inducibility of Aryl Hydrocarbon Hydroxylase2

1 reference

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21 January 2018

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

1 reference

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21 January 2018

Epoxides in polycyclic aromatic hydrocarbon metabolism and carcinogenesis.

4

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12 April 2023

Molecular Pharmacology

9

11

874

author name string

Kawalek J. C.

publication date

1975

1 reference

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12 April 2023

A gel-electrophoretically homogeneous preparation of cytochrome P-450 from liver microsomes of phenobarbital-pretreated rabbits

10

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12 April 2023

Purification of a substrate complex of cytochrome P-450 from liver microsomes of 3-methylcholanthrene-treated rabbits

11

1 reference

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Highly purified cytochrome P-450 from liver microsomal membranes: recent studies on the mechanism of catalysis

14

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Molecular Pharmacology

16

12

322

author name string

Sugiura M.

publication date

1976

1 reference

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12 April 2023

Enzymic reduction of aromatic hydrocarbon epoxides by the microsomal fraction of rat liver

17

1 reference

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12 April 2023

Cancer Research

20

37

1443

author name string

Alexandrov K.

publication date

1977

1 reference

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12 April 2023

Evidence for a 2,3-epoxide as an intermediate in the microsomal metabolism of benzo[a]pyrene to 3-hydroxybenzo[a]pyrene

21

1 reference

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12 April 2023

Deuterium isotope effects during formation of phenols by hepatic monoxygenases. Evidence for an alternative to the arene oxide pathway

22

1 reference

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12 April 2023

Evidence for the Activation of 3-Methylcholanthrene as a Carcinogen in vivo and as a Mutagen in vitro by P1-450 from Inbred Strains of Mice

26

1 reference

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12 April 2023

Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo

28

1 reference

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12 April 2023

Molecular Pharmacology

30

11

159

author name string

Thorgeirsson S. S.

publication date

1975

1 reference

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12 April 2023

Metabolism of benzo[a]pyrene. Effect of substrate concentration and 3-methylcholanthrene pretreatment on hepatic metabolism by microsomes from rats and mice

31

1 reference

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12 April 2023

Molecular Pharmacology

33

11

850

author name string

Robinson J. R.

publication date

1975

1 reference

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12 April 2023

Studies on microsomal hydroxylation and the demonstration of a new carbon monoxide binding pigment in liver microsomes

35

1 reference

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12 April 2023

Phenobarbital-mediated increase in ring- and N-hydroxylation of the carcinogen N-2-fluorenylacetamide, and decrease in amounts bound to liver deoxyribonucleic acid

36

1 reference

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12 April 2023

Molecular Pharmacology

37

9

398

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Thorgeirsson S. S.

publication date

1973

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12 April 2023

Journal of Pharmacology and Experimental Therapeutics

38

187

218

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Zampaglione N.

publication date

1973

1 reference

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12 April 2023

Cancer Research

40

33

1937

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Kinoshita N.

publication date

1973

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12 April 2023

Cancer Research

41

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2290

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Rasmussen R. E.

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1974

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12 April 2023

The metabolism of benzo[a]pyrene by rat-liver homogenates

46

1 reference

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12 April 2023

Separation of ten benzo(a)pyrene phenols by recycle high pressure liquid chromatography and identification of four phenols as metabolites

47

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12 April 2023

Metabolism of benzo[a]pyrene. III. An evaluation of the fluorescence assay

48

1 reference

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12 April 2023

A simple radioisotope assay for microsomal aryl hydroxylase

49

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12 April 2023

Molecular Pharmacology

53

8

651

author name string

Nebert D. W.

publication date

1972

1 reference

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12 April 2023

Guidelines for nomenclature of genetically determined biochemical variants in the house mouse, Mus musculus

54

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12 April 2023

Aryl Hydrocarbon Hydroxylase Induction by Polycyclic Hydrocarbons: Simple Autosomal Dominant Trait in the Mouse

56

1 reference

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12 April 2023

The genetics of aryl hydrocarbon hydroxylase induction in mice: A single gene difference between C57BL/6J and DBA/2J

57

1 reference

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12 April 2023

Genetics of aryl hydrocarbon hydroxylase induction in mice: additive inheritance in crosses between C3H-HeJ and DBA-2J

59

1 reference

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12 April 2023

Association of the Ah locus with specific changes in metyrapone and ethylisocyanide binding to mouse liver microsomes

63

1 reference

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12 April 2023

Enzymatic conjugation of benzo (a) pyrene oxides, phenols and dihydrodiols with UDP-glucuronic acid

65

1 reference

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12 April 2023

Molecular Pharmacology

69

10

484

author name string

Robinson J. R.

publication date

1974

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12 April 2023

Molecular Pharmacology

70

12

225

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Felton J. S.

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1976

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12 April 2023

Cancer Research

72

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460

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Burke M. D.

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1977

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12 April 2023

Molecular Pharmacology

75

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259

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Boobis A. R.

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1977

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12 April 2023

Organic solvent soluble sulphate ester conjugates of monohydroxybenzo(a)pyrenes

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12 April 2023

Molecular Pharmacology

81

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476

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Rispin A. S.

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1976

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12 April 2023

Cancer Research

84

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2059

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Marquardt H.

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1976

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12 April 2023

Cancer Research

85

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3625

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Kapitulnik J.

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1976

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12 April 2023

Cancer Research

89

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3474

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Selkirk J. K.

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1974

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12 April 2023

Cancer Research

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4476

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Selkirk J. K.

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1976

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12 April 2023

Molecular Pharmacology

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Robinson J. R.

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12 April 2023

Cancer Research

100

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2378

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Baird W. M.

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1973

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12 April 2023

Cancer Research

104

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2777

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Kouri R. E.

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1978

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12 April 2023

High-pressure liquid chromatography of carcinogen-nucleoside conjugates: separation of 7,12-dimethylbenzanthracene derivatives

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12 April 2023

Cancer Research

108

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1263

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King H. W. S.

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1975

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12 April 2023

Molecular Pharmacology

112

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Pelkonen O.

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1978

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12 April 2023

Pharmacological Reviews

120

25

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Weisburger J. H.

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1973

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12 April 2023

Enzyme-catalyzed reactions of the carcinogen N-hydroxy-2-fluorenylacetamide with nucleic acid

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12 April 2023

Cancer Research

122

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DeBaun J. R.

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1970

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12 April 2023

Cancer Research

124

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King C. M

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1974

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12 April 2023

On the metabolic activation of the carcinogen N-hydroxy-N-2-acetylaminofluorene. 3. Oxidation with horseradish peroxidase to yield 2-nitrosofluorene and N-acetoxy-N-2-acetylaminofluorene

125

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12 April 2023

N-acetoxy-N-acetylaminoarenes and nitrosoarenes one-electron non-enzymatic and enzymatic oxidation products of various carcinogenic aromatic acethydroxamic acids

126

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12 April 2023

Journal of Pharmacology and Experimental Therapeutics

127

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Mitchell J. R.

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1973

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12 April 2023

Journal of Pharmacology and Experimental Therapeutics

142

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195

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Jollow D. J.

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1973

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12 April 2023

Journal of Pharmacology and Experimental Therapeutics

143

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211

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Mitchell J. R.

publication date

1973

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12 April 2023

Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy.

145

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12 April 2023

Acetaminophen overdoses at a county hospital: a year's experience

146

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12 April 2023

Aryl hydrocarbon hydroxylase induction in human lymphocyte cultures by 2,3,7,8-tetrachlorodibenzo-p-dioxin

149

1 reference

10.3109/10409237909105427

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12 April 2023

Cancer Research

150

35

1235

author name string

Gurtoo H. L.

publication date

1975

1 reference

10.3109/10409237909105427

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12 April 2023

Cancer Research

151

36

4619

author name string

Atlas S. A.

publication date

1976

1 reference

10.3109/10409237909105427

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12 April 2023

Cancer Research

153

37

3904

author name string

Okuda T.

publication date

1977

1 reference

10.3109/10409237909105427

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12 April 2023

Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice

160

1 reference

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12 April 2023

162

17

213

author name string

Levitt R. C.

publication date

1975

1 reference

10.3109/10409237909105427

https://api.crossref.org/works/10.3109/10409237909105427

12 April 2023

Effects of harman and norharman on the mutagenicity and binding to DNA of benzo[a]pyrene metabolites in vitro and on aryl hydrocarbon hydroxylase induction in cell culture

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12 April 2023

Identifiers

10.3109/10409237909105427

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

ResearchGate publication ID

0 references

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