(Q39834900)

15 September 2017

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title

Importance of drug enantiomers in clinical pharmacology (English)

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15 September 2017

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K Williams

1

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PubMed ID

3905334

15 September 2017

E Lee

series ordinal

2

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15 September 2017

1 October 1985

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15 September 2017

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15 September 2017

30

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15 September 2017

333-354

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15 September 2017

4

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https://scigraph.springernature.com/pub.10.2165/00003495-198530040-00003

15 September 2017

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12 December 2020

Epimers of moxalactam: in vitro comparison of activity and stability

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12 December 2020

Enantiomers of indacrinone: a new approach to producing an isouricemic diuretic

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12 December 2020

Interrelationships between xenobiotic metabolism and lipid biosynthesis

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12 December 2020

Dynamic interaction between disulfiram and separated enantiomorphs of racemic warfarin

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12 December 2020

Inotropic and electrophysiological actions of verapamil and D 600 in mammalian myocardium. III. Effects of the optical isomers on transmembrane action potentials

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12 December 2020

Optical isomers of verapamil on canine heart. Prevention of ventricular fibrillation induced by coronary artery occlusion, impaired atrioventricular conductance and negative inotropic and chronotropic effects

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12 December 2020

The stereoselective interaction of warfarin and metronidazole in man

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12 December 2020

Pharmacokinetic implications of stereoselective changes in plasma-protein binding: warfarin/sulfinpyrazone

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12 December 2020

Steric aspects of adrenergic drugs

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12 December 2020

Stereoselective binding of propranolol to human plasma, alpha 1-acid glycoprotein, and albumin

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12 December 2020

Pathways of metabolism of amphetamine and related compounds

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12 December 2020

Studies on the interaction of warfarin and clofibrate in man.

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12 December 2020

Serum protein binding as a determinant of warfarin body clearance and anticoagulant effect

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12 December 2020

Kinetics of misonidazole enantiomers

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12 December 2020

Sulphinpyrazone and warfarin: a probable drug interaction

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12 December 2020

Effect of l-propoxyphene on plasma levels and analgesic activity of d-propoxyphene in the rat.

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12 December 2020

Stereoselective disposition of ibuprofen enantiomers in man

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12 December 2020

The binding of the optical isomers of methadone, alpha-methadol, alpha-acetylmethadol and their N-demethylated derivatives to the opiate receptors of rat brain

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12 December 2020

Propranolol and essential tremor: rôle of the membrane effect

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12 December 2020

Pharmacology of enantiomers and (–) p-OH metabolite of indacrinone

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12 December 2020

Stereoselective binding of disopyramide to human plasma protein

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12 December 2020

Oxidation of (R)- and (S)-propranolol in human and dog liver microsomes. Species differences in stereoselectivity

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12 December 2020

Comparative pharmacokinetics of coumarin anticoagulants XXXVI: Predicted steady-state patterns of prothrombin complex activity produced by equieffective doses of (R)-(+)- and (S)-(-)-warfarin in humans

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12 December 2020

High stereospecificity of the benzodiazepine binding site on human serum albumin. Studies with d- and l-oxazepam hemisuccinate

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12 December 2020

Enhancement of uricosuric properties of indacrinone by manipulation of the enantiomer ratio

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12 December 2020

Phenylbutazone-warfarin interaction in man: further stereochemical and metabolic considerations

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12 December 2020

Effects of pretreatment with phenobarbitone and phenytoin on the pharmacokinetics and toxicity of phenytoin on the pharmacokinetics and toxicity of misonidazole in mice

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12 December 2020

Respiratory and subjective effects of dand l-pentazocine.

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12 December 2020

Relationship of antiarrhythmic to inotropic activity and antiarrhythmic qualities of the optical isomers of verapamil

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12 December 2020

Methadone in man: Pharmacokinetic and excretion studies in acute and chronic treatment

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12 December 2020

Stereoselective inversion of (R)-(-)-benoxaprofen to the (S)-(+)-enantiomer in humans

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12 December 2020

Potentiation of anticoagulant effect of warfarin by phenylbutazone

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12 December 2020

Possible interaction of sulfinpyrazone with coumarins

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12 December 2020

Separation of morphine-like effects by optical resolution. Levo isomers as strong analgetics and narcotic antagonists

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12 December 2020

Optical studies on the mechanism of the interaction of the enantiomers of the antiocagulant drugs phenprocoumon and warfarin with human serum albumin

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12 December 2020

Some comparative effects of racemic methadone and its optical isomers in rodents

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12 December 2020

Potentiation of warfarin action by sulphinpyrazone

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12 December 2020

Antimalarial activity of the optical isomers of chloroquine diphosphate

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12 December 2020

Stereoselective interaction of trimethoprim-sulfamethoxazole with the separated enantiomorphs of racemic warfarin in man

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12 December 2020

Regional hemodynamic effects of beta-adrenergic blockade with propranolol in the unanesthetized primate

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12 December 2020

Pharmacokinetics of (+)-, (-)- and (+/-)-verapamil after intravenous administration

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12 December 2020

Kinetics of microsomal metabolism and binding of enantiomerically related substrates.

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12 December 2020

Stereospecific binding of timolol, a beta-adrenergic blocking agent

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12 December 2020

The disposition of propranolol. VII. The effects of saturable hepatic tissue uptake on drug clearance by the perfused rat liver

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12 December 2020

Stereoselective inversion of (R)-fenoprofen to (S)-fenoprofen in humans

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12 December 2020

Modification of Parkinsonism--chronic treatment with L-dopa

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12 December 2020

Stereoselective oral bioavailability of (+/-)-propranolol in the dog. A GC-MS study using a stable isotope technique

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12 December 2020

Recent advances in methods of direct optical resolution

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12 December 2020

Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology

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12 December 2020

Ticrynafen-racemic warfarin interaction: hepatotoxic or stereoselective?

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12 December 2020

Stereoselective disposition of methadone in man.

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12 December 2020

The relation between biological activity and the degree of resolution of optical isomers

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12 December 2020

Stereoselective binding of propranolol enantiomers to human alpha 1-acid glycoprotein and human plasma

1 reference

12 December 2020

Plasma levels of (+) and (-)-propranolol and 4-hydroxypropranolol after administration of racemic (+/-)-propranolol in man

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12 December 2020

The participation of ethyl 4-benzyloxybenzoate (BRL 10894) and other aryl-substituted acids in glycerolipid metabolism

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12 December 2020

Stereoselective first-pass metabolism of highly cleared drugs: studies of the bioavailability of L- and D-verapamil examined with a stable isotope technique

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12 December 2020

Noninvasive chemical methods of estimating pharmacokinetic parameters

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12 December 2020

Absorption, distribution and toxicity of ibuprofen

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12 December 2020

Analgesic and other effects of the d- and l-isomers of penzocine

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12 December 2020

Pharmacokinetics of the enantiomers of indoprofen in man

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12 December 2020

Commentary: a physiological approach to hepatic drug clearance

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12 December 2020

Single dose pharmacokinetics and bioavailability of methadone in man studied with a stable isotope method

1 reference

12 December 2020

The disposition of propranolol. 3. Decreased half-life and volume of distribution as a result of plasma binding in man, monkey, dog and rat

1 reference

12 December 2020

Pharmacokinetics of the enantiomers of acenocoumarol in man.

1 reference

12 December 2020

Effects of verapamil on P-R-intervals in relation to verapamil plasma levels following single i.v. and oral administration and during chronic treatment

1 reference

12 December 2020

Quantitation of methadone enantiomers in humans using stable isotope-labeled [2H3]-, [2H5]-, and [2H8]Methadone

1 reference

12 December 2020

Studies on the optical enantiomorphs of warfarin in man

1 reference

12 December 2020

Benzodiazepines: specific competitors for the binding of L-tryptophan to human serum albumin

1 reference

12 December 2020

The importance of stereochemistry in the clinical pharmacokinetics of the 2-arylpropionic acid non-steroidal anti-inflammatory drugs

1 reference

12 December 2020

Interaction of clofibrate with warfarin. I. Effect of clofibrate on the disposition of the optical enantiomorphs of warfarin

1 reference

12 December 2020

Observations on the differential metabolism and biological activity of the optical isomers of cyclophosphamide

1 reference

12 December 2020

Mechanism of Action of Barbiturates

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12 December 2020

Effects of phenylbutazone, tolbutamide, and clofibric acid on binding of racemic warfarin and its enantiomers to human serum albumin

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12 December 2020

Interaction of secobarbital with warfarin pseudoracemates

1 reference

12 December 2020

Side effects of levomethadone and racemic methadone in a maintenance program

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12 December 2020

Indacrinone: natriuretic and uricosuric effects of various ratios of its enantiomers in healthy men.

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12 December 2020

Optical resolution of some homobenzomorphan derivatives and their pharmacological properties

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12 December 2020

Present status of enantiomeric analysis by gas chromatography

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12 December 2020

Liquid Chromatographic Determination and Plasma Concentration Profile of Optical Isomers of Ibuprofen in Humans

1 reference

12 December 2020

Protein binding of warfarin enantiomers in serum of humans and rats

1 reference

12 December 2020

The effect of d-timolol on intraocular pressure in patients with ocular hypertension

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12 December 2020

No stereoselective first-pass hepatic extraction of propranolol

1 reference

12 December 2020

Pharmacokinetics of warfarin enantiomers: A search for intrasubject correlations

1 reference

12 December 2020

The specific binding of L-tryptophan to serum albumin

1 reference

12 December 2020

Stereochemical aspects of para-chloroamphetamine metabolism. Rabbit liver microsomal metabolism of RS-, R(-)-. and S(+)-para-chloroamphetamine

1 reference

12 December 2020

The metabolism of ibuprofen

1 reference

12 December 2020

Pharmacological differences between the optical isomers of ibuprofen: evidence for metabolic inversion of the (—)-isomer

1 reference

12 December 2020

Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers

1 reference

12 December 2020

Racemic Warfarin and Trimethoprim-Sulfamethoxazole Interaction in Humans

1 reference

12 December 2020

Cerebral protection with barbiturates: relation to anesthetic effect

1 reference

12 December 2020

Stereoselective interaction of phenylbutazone with [12C/13C]warfarin pseudoracemates in man

1 reference

12 December 2020

Treatment of acute focal cerebral ischemia with propranolol.

1 reference

12 December 2020

Effects of verapamil and its optical isomers on repetitive slow responses induced by electrical depolarization in canine ventricular myocardium

1 reference

12 December 2020

The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias

1 reference

12 December 2020

Drug interactions with warfarin

1 reference

12 December 2020

Entero-hepatic cycling of methotrexate estimated by use of the D-isomer as a reference marker

1 reference

12 December 2020

Effects of enantiomers of indacrinone (MK-196) on cation transport by the loop of Henle and distal tubule studied by microperfusion in vivo

1 reference

12 December 2020

Clinical effects and pharmacokinetics of racemic methadone and its optical isomers

1 reference

12 December 2020

Anticoagulant activity of the enantiomers of acenocoumarol

1 reference

12 December 2020

Stereoselective interaction of sulfinpyrazone with racemic warfarin and its separated enantiomorphs in man

1 reference

12 December 2020

Effects of phenytoin, phenobarbital, and ascorbic acid on misonidazole elimination

1 reference

12 December 2020

The metabolism and antitumour activity of the enantiomers of cis- and trans-4-methylcyclophosphamide

1 reference

12 December 2020

A critical evaluation of the application of amino acid racemization to geochronology and geothermometry

1 reference

12 December 2020

Stereospecific inversion of (R)-(-)-benoxaprofen in rat and man

1 reference

12 December 2020

Optical isomers of miscellaneous strong analgetics

1 reference

12 December 2020

Enzyme Reaction Stereospecificity: A Critical Revie

1 reference

12 December 2020

Stereospecific radioimmunoassay for propranolol isomers

1 reference

12 December 2020

Stereoselectivity in the disposition and metabolism of the uricosuric-diuretic agent, indacrinone, in Rhesus monkeys

1 reference

12 December 2020

The metabolic chiral inversion of 2-arylpropionic acids—a novel route with pharmacological consequences

1 reference

12 December 2020

High-performance liquid chromatographic determination of stereoselective disposition of carprofen in humans

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of the enantiomers of warfarin in man

1 reference

12 December 2020

Stereospecific assay for (-)- and (+)-propranolol in human and dog plasma

1 reference

12 December 2020

Determination of moxalactam in human body fluids by liquid chromatographic and microbiological methods

1 reference

12 December 2020

Stereoselective binding of the (-)-enantiomer of propranolol to plasma and extravascular binding sites in the dog

1 reference

12 December 2020

Active Transport of L-Dopa in the Intestine

1 reference

12 December 2020

Molecular geometry and adrenergic drug activity.

1 reference

12 December 2020

Warfarin. Stereochemical aspects of its metabolism and the interaction with phenylbutazone

1 reference

12 December 2020

The hemodynamic effects of beta adrenergic blockade on the flow-dependent hepatic clearance of propranolol

1 reference

12 December 2020

Comparative Pharmacokinetics of Coumarin Anticoagulants XIV: Relationship between Protein Binding, Distribution, and Elimination Kinetics of Warfarin in Rats

1 reference

12 December 2020

Comparative interaction of sulfinpyrazone and phenylbutazone with racemic warfarin: alteration in vivo of free fraction of plasma warfarin

1 reference

12 December 2020

The influence of stereochemical factors on drug disposition

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12 December 2020

Coronary vasodilator and cardiac effects of optical isomers of verapamil in the dog.

1 reference

12 December 2020

Stereoselective disposition--basis for variability in response to NSAID's

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12 December 2020

Stereoisomerism and drug action in the nervous system

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12 December 2020

Stereospecific salivary excretion of tocainide enantiomers in man.

1 reference

12 December 2020

Altered Hepatic Blood Flow and Drug Disposition1

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12 December 2020

Chromatographic resolution of enantiomers selective review

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12 December 2020

The enantiomers of phenprocoumon: pharmacodynamic and pharmacokinetic studies

1 reference

12 December 2020

Effect of pentobarbital on the formation of diastereomeric oxazepam glucuronides in man: analysis by high performance liquid chromatography

1 reference

12 December 2020

10.2165/00003495-198530040-00003

Identifiers

DOI

1 reference

PubMed ID

3905334

Dimensions Publication ID

15 September 2017

0 references

1 reference

PubMed ID

3905334