(Q39868291)

15 September 2017

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans (English)

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15 September 2017

Caenorhabditis elegans

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2

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15 September 2017

6

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15 September 2017

7

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15 September 2017

Jan Wildenhain

3

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author name string

Andrew R Burns

1

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15 September 2017

Mike Tyers

4

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15 September 2017

Guri Giaever

5

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15 September 2017

Sean R Cutler

8

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15 September 2017

Peter J Roy

9

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15 September 2017

30 May 2010

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15 September 2017

Nature Chemical Biology

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15 September 2017

6

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15 September 2017

549-557

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15 September 2017

7

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https://scigraph.springernature.com/pub.10.1038/nchembio.380

15 September 2017

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cites work

Xenobiotic detoxification in the nematode Caenorhabditis elegans

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.380

Selectivity of substance identification by HPLC-DAD in toxicological analysis using a UV spectra library of 2682 compounds

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.380

Reoptimization of MDL keys for use in drug discovery

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.380

Integration of biological networks and gene expression data using Cytoscape

21 January 2018

1 reference

12 December 2020

Chemical substructures that enrich for biological activity

1 reference

12 December 2020

The nongenotoxic carcinogens naphthalene and para-dichlorobenzene suppress apoptosis in Caenorhabditis elegans

1 reference

12 December 2020

Pharmacologic properties of fenbufen

1 reference

12 December 2020

Quantifying biogenic bias in screening libraries

1 reference

12 December 2020

Finding function in novel targets: C. elegans as a model organism.

1 reference

12 December 2020

Scaffold composition and biological relevance of screening libraries.

1 reference

12 December 2020

ZINC--a free database of commercially available compounds for virtual screening

1 reference

12 December 2020

A new class of anthelmintics effective against drug-resistant nematodes

1 reference

12 December 2020

Ionic basis of the resting membrane potential and action potential in the pharyngeal muscle of Caenorhabditis elegans

1 reference

12 December 2020

Using extended-connectivity fingerprints with Laplacian-modified Bayesian analysis in high-throughput screening follow-up

1 reference

12 December 2020

High-throughput screening of small molecules for bioactivity and target identification in Caenorhabditis elegans

1 reference

12 December 2020

N-glucosylation of cytokinins by glycosyltransferases of Arabidopsis thaliana

1 reference

12 December 2020

Fluoxetine-resistant mutants in C. elegans define a novel family of transmembrane proteins

1 reference

12 December 2020

Genetic pharmacology: interactions between drugs and gene products in Caenorhabditis elegans

1 reference

12 December 2020

Cuticle of Caenorhabditis elegans: its isolation and partial characterization

1 reference

12 December 2020

New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products

1 reference

12 December 2020

Food transport in the C. elegans pharynx

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12 December 2020

Chemistry-to-gene screens in Caenorhabditis elegans

1 reference

12 December 2020

An antidepressant that extends lifespan in adult Caenorhabditis elegans

1 reference

12 December 2020

A P-glycoprotein protects Caenorhabditis elegans against natural toxins

1 reference

12 December 2020

New 4-point pharmacophore method for molecular similarity and diversity applications: overview of the method and applications, including a novel approach to the design of combinatorial libraries containing privileged substructures

1 reference

12 December 2020

A small-molecule screen in C. elegans yields a new calcium channel antagonist

1 reference

12 December 2020

Privileged molecules for protein binding identified from NMR-based screening

1 reference

12 December 2020

A lymphotropic prodrug of L-dopa: synthesis, pharmacological properties, and pharmacokinetic behavior of 1,3-dihexadecanoyl-2-[(S)-2-amino-3-(3,4-dihydroxyphenyl)prop anoyl] propane-1,2,3-triol

1 reference

12 December 2020

Evidence from opiate binding studies that heroin acts through its metabolites

1 reference

12 December 2020

Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists

1 reference

12 December 2020

Molecular docking and ligand specificity in fragment-based inhibitor discovery

1 reference

12 December 2020

The properties of known drugs. 1. Molecular frameworks

1 reference

12 December 2020

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

12 December 2020

The L-type voltage-dependent Ca2+ channel EGL-19 controls body wall muscle function in Caenorhabditis elegans

1 reference

12 December 2020

Integrating high-content screening and ligand-target prediction to identify mechanism of action

1 reference

12 December 2020

Classification of kinase inhibitors using a Bayesian model

1 reference

12 December 2020

An integrated platform of genomic assays reveals small-molecule bioactivities

1 reference

12 December 2020

A genetic screen for dihydropyridine (DHP)-resistant worms reveals new residues required for DHP-blockage of mammalian calcium channels

1 reference

12 December 2020

Shift of the high-performance liquid chromatographic retention times of metabolites in relation to the original drug on an RP8 column with acidic mobile phase.

1 reference

12 December 2020

The combinatorial synthesis of bicyclic privileged structures or privileged substructures.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.380

1 reference

15 September 2017

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