(Q39872431)

English

An active-site mutation in the human immunodeficiency virus type 1 proteinase (PR) causes reduced PR activity and loss of PR-mediated cytotoxicity without apparent effect on virus maturation and infectivity

scientific article published on November 1995

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scholarly article

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19 October 2019

An active-site mutation in the human immunodeficiency virus type 1 proteinase (PR) causes reduced PR activity and loss of PR-mediated cytotoxicity without apparent effect on virus maturation and infectivity (English)

1 reference

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19 October 2019

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Konvalinka J

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19 October 2019

Hans-Georg Kräusslich

7

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Kräusslich HG

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19 October 2019

author name string

Litterst MA

2

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19 October 2019

Welker R

3

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19 October 2019

Kottler H

4

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19 October 2019

Rippmann F

5

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19 October 2019

Heuser AM

6

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19 October 2019

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publication date

1 November 1995

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19 October 2019

Journal of Virology

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19 October 2019

69

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19 October 2019

7180-7186

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19 October 2019

11

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19 October 2019

Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles.

1 reference

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Proteolytic processing of Ty3 proteins is required for transposition

1 reference

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22 September 2017

Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity

1 reference

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Active foamy virus proteinase is essential for virus infectivity but not for formation of a Pol polyprotein

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22 September 2017

Rapid and efficient site-specific mutagenesis without phenotypic selection

1 reference

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22 September 2017

Standardized and simplified nomenclature for proteins common to all retroviruses

1 reference

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22 September 2017

Active human immunodeficiency virus protease is required for viral infectivity

1 reference

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22 September 2017

Phenotypic variation in the response to the human immunodeficiency virus among derivatives of the CEM T and WIL-2 B cell lines

1 reference

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22 September 2017

Viral proteinases

1 reference

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22 September 2017

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

1 reference

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Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay

1 reference

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22 September 2017

Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease

1 reference

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22 September 2017

Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases

1 reference

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22 September 2017

Human immunodeficiency virus type 1 protease cleaves the intermediate filament proteins vimentin, desmin, and glial fibrillary acidic protein

1 reference

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22 September 2017

Use of T7 RNA polymerase to direct expression of cloned genes

1 reference

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22 September 2017

The structure and function of the aspartic proteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=189639

22 September 2017

Sensitive, soluble chromogenic substrates for HIV-1 proteinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=189639

22 September 2017

Rational design of peptide-based HIV proteinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=189639

22 September 2017

Human immunodeficiency virus type 1 Gag proteins are processed in two cellular compartments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=189639

22 September 2017

Human immunodeficiency virus proteinase dimer as component of the viral polyprotein prevents particle assembly and viral infectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=189639

22 September 2017

Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=189639

22 September 2017

Specific inhibitor of human immunodeficiency virus proteinase prevents the cytotoxic effects of a single-chain proteinase dimer and restores particle formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=189639

22 September 2017

Degradation of cytoskeletal proteins by the human immunodeficiency virus type 1 protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=189639

22 September 2017

Cleavage of bovine brain microtubule-associated protein-2 by human immunodeficiency virus proteinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=189639

22 September 2017

Structural studies of the retroviral proteinase from avian myeloblastosis associated virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=189639

22 September 2017

Structure-based inhibitors of HIV-1 protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=189639

25 September 2017

Kinetic studies of human immunodeficiency virus type 1 protease and its active-site hydrogen bond mutant A28S

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=189639

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Analysis of protein expression and virus-like particle formation in mammalian cell lines stably expressing HIV-1 gag and env gene products with or without active HIV proteinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=189639

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Restricted expression of human T-cell leukemia--lymphoma virus (HTLV) in transformed human umbilical cord blood lymphocytes

1 reference

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17 June 2018

Avian retroviral protease and cellular aspartic proteases are distinguished by activities on peptide substrates.

1 reference

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Processing of the precursor of NF-kappa B by the HIV-1 protease during acute infection

1 reference

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Role of the gag and pol genes of human immunodeficiency virus in the morphogenesis and maturation of retrovirus-like particles expressed by recombinant vaccinia virus: an ultrastructural study

1 reference

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Specificity studies on retroviral proteinase from myeloblastosis-associated virus

1 reference

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17 June 2018

An engineered retroviral proteinase from myeloblastosis associated virus acquires pH dependence and substrate specificity of the HIV-1 proteinase

1 reference

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Analysis of substrate interactions of the Rous sarcoma virus wild type and mutant proteases and human immunodeficiency virus-1 protease using a set of systematically altered peptide substrates

1 reference

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Myeloblastosis associated virus (MAV) proteinase site-mutated to be HIV-like has a higher activity and allows production of infectious but morphologically altered virus

1 reference

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Expression in Escherichia coli and purification of human immunodeficiency virus type 1 capsid protein (p24).

1 reference

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20 August 2018

Analysis of HIV particle formation using transient expression of subviral constructs in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7474139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic Processing of Particle-Associated Retroviral Polyproteins by Homologous and Heterologous Viral Proteinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/7474139

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.69.11.7180-7186.1995

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7474139%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7474139%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

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