(Q39956386)

15 September 2017

title

Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins (English)

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15 September 2017

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8

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15 September 2017

K E Tagscherer

1

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15 September 2017

A Fassl

2

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15 September 2017

B Campos

3

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15 September 2017

M Farhadi

4

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15 September 2017

A Kraemer

5

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15 September 2017

B C Böck

6

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15 September 2017

S Macher-Goeppinger

7

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15 September 2017

O D Wiestler

9

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15 September 2017

C Herold-Mende

10

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15 September 2017

W Roth

11

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15 September 2017

language of work or name

English

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publication date

28 July 2008

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15 September 2017

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15 September 2017

volume

27

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15 September 2017

issue

52

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15 September 2017

page(s)

6646-6656

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Subversion of the Bcl-2 life/death switch in cancer development and therapy.

15 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Antiglioma activity of 2,2':6',2"-terpyridineplatinum(II) complexes in a rat model--effects on cellular redox metabolism

31 March 2020

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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

31 March 2020

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.259

A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.

31 March 2020

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Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Bcl-2 overexpression decreases BCNU sensitivity of a human glioblastoma line through enhancement of catalase activity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

31 March 2020

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BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia.

31 March 2020

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BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

31 March 2020

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Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion

31 March 2020

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Comparative analysis of in vitro conditions for rat adult neural progenitor cells.

31 March 2020

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Chemotherapy resistance of glioblastoma stem cells

31 March 2020

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Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression.

31 March 2020

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Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

31 March 2020

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Determination of cell number in monolayer cultures

31 March 2020

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Death ligand/receptor-independent caspase activation mediates drug-induced cytotoxic cell death in human malignant glioma cells

31 March 2020

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Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas

31 March 2020

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31 March 2020

At the gates of death.

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Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer

31 March 2020

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BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells

31 March 2020

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Expression of survivin in astrocytic tumors: correlation with malignant grade and prognosis

31 March 2020

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Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Different angiogenic phenotypes in primary and secondary glioblastomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

TP53 gene mutations, nuclear p53 accumulation, expression of Waf/p21, Bcl-2, and CD95 (APO-1/Fas) proteins are not prognostic factors in de novo glioblastoma multiforme

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Restoring cancer's death sentence

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Drug insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

APO2 ligand: a novel lethal weapon against malignant glioma?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Neural stem cells and the origin of gliomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Targeting brain-tumor stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Expression and biological activity of X-linked inhibitor of apoptosis (XIAP) in human malignant glioma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

BCL-xL: time-dependent dissociation between modulation of apoptosis and invasiveness in human malignant glioma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

Antisense to apoptosis inhibitors facilitates chemotherapy and TRAIL-induced death signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.259

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.259

1 reference

15 September 2017

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