(Q39986537)

16 September 2017

title

Characterization of the human QT interval: novel distribution-based assessment of the repolarization effects of moxifloxacin (English)

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16 September 2017

Henry H Holzgrefe

1

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16 September 2017

Georg Ferber

2

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16 September 2017

Royce Morrison

3

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16 September 2017

Olivier Meyer

4

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16 September 2017

Andrea Greiter-Wilke

5

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16 September 2017

Thomas Singer

6

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16 September 2017

publication date

9 June 2011

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The Journal of Clinical Pharmacology

16 September 2017

published in

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16 September 2017

volume

52

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16 September 2017

issue

8

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16 September 2017

page(s)

1222-1239

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

16 September 2017

cites work

1 reference

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Facts, fancies and follies of drug-induced QT/QTc interval shortening

21 January 2018

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Novel probabilistic method for precisely correcting the QT interval for heart rate in telemetered dogs and cynomolgus monkeys

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270011409234

Accurately measured and properly heart-rate corrected QTc intervals show little daytime variability

21 January 2018

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Pharmacokinetics and pharmacodynamics of three moxifloxacin dosage forms: implications for blinding in active-controlled cardiac repolarization studies.

21 January 2018

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"Optimum" formulae for heart rate correction of the QT interval.

21 January 2018

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Problems of heart rate correction in assessment of drug-induced QT interval prolongation.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270011409234

QT dispersion does not represent electrocardiographic interlead heterogeneity of ventricular repolarization

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270011409234

Statistical methods for assessing agreement between two methods of clinical measurement

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270011409234

Application of a probabilistic method for the determination of drug-induced QT prolongation in telemetered cynomolgus monkeys: effects of moxifloxacin

21 January 2018

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Statistical power of multiplicity adjustment strategies for correlated binary endpoints.

21 January 2018

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Comparison of QTinno, a fully automated electrocardiographic analysis program, to semiautomated electrocardiographic analysis methods in a drug safety study in healthy subjects.

21 January 2018

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Comparison of semiautomated and fully automated methods for QT measurement during a thorough QT/QTc study: variability and sample size considerations.

21 January 2018

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A comparison of three software platforms for automated ECG analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270011409234

Characterization of QT interval adaptation to RR interval changes and its use as a risk-stratifier of arrhythmic mortality in amiodarone-treated survivors of acute myocardial infarction.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270011409234

Mechanisms of ventricular rate adaptation as a predictor of arrhythmic risk

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270011409234

Bias and variance evaluation of QT interval correction methods.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270011409234

Clinical assessment of drug-induced QT prolongation in association with heart rate changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270011409234

QT prolongation modifies dynamic restitution and hysteresis of the beat-to-beat QT-TQ interval relationship during normal sinus rhythm under varying states of repolarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270011409234

Use of the average baseline versus the time-matched baseline in parallel group thorough QT/QTc studies.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270011409234

Circadian modulation of QT rate dependence in healthy volunteers: gender and age differences

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270011409234

Rate-correction technique for QT interval in long-term telemetry ECG recording in beagle dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270011409234

Circadian rhythm of the corrected QT interval: impact of different heart rate correction models

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270011409234

Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology

21 January 2018

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QT-RR relationship in healthy subjects exhibits substantial intersubject variability and high intrasubject stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270011409234

A novel approach to data processing of the QT interval response in the conscious telemetered beagle dog.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270011409234

New confidence bounds for QT studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270011409234

Comment on 'New confidence bounds for QT studies' by Dennis D. Boos, David Hoffman, Robert Kringle and Ji Zhang, Statistics in Medicine 2007; 26:3801-3817.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270011409234

Investigating Drug-Induced QT and QTc Prolongation in the Clinic: A Review of Statistical Design and Analysis Considerations: Report from the Pharmaceutical Research and Manufacturers of America QT Statistics Expert Team

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270011409234

Estimation of the QT/RR hysteresis lag

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270011409234

21 January 2018

Identifiers

DOI

10.1177/0091270011409234

1 reference

16 September 2017

1 reference