(Q40050373)

16 September 2017

Genetic knockouts and knockins in human somatic cells (English)

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16 September 2017

2

Bert Vogelstein

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author name string

Carlo Rago

series ordinal

1

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PubMed ID

18007609

16 September 2017

Fred Bunz

series ordinal

3

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16 September 2017

1 January 2007

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16 September 2017

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16 September 2017

2

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16 September 2017

2734-2746

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16 September 2017

11

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https://scigraph.springernature.com/pub.10.1038/nprot.2007.408

16 September 2017

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cites work

Genetic alterations during colorectal-tumor development

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Tumour suppression: disruption of HAUSP gene stabilizes p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

A generic intron increases gene expression in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Analysis of biological selections for high-efficiency gene targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Computational biology. Counting on the neuron.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Activation of the interferon system by short-interfering RNAs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Expression profiling reveals off-target gene regulation by RNAi

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Induction of an interferon response by RNAi vectors in mammalian cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

The multistep nature of cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Prevalence of somatic alterations in the colorectal cancer cell genome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

The consensus coding sequences of human breast and colorectal cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Genetic instability in colorectal cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Genetic instabilities in human cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Hypermutability and mismatch repair deficiency in RER+ tumor cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Construction by gene targeting in human cells of a "conditional' CDC2 mutant that rereplicates its DNA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Targeted transgene insertion into human chromosomes by adeno-associated virus vectors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Interleukin-1 alpha mediates the growth proliferative effects of transforming growth factor-beta in p21 null MCF-10A human mammary epithelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Gene targeting in stem cells from individuals with osteogenesis imperfecta

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Gene targeting and somatic cell genetics--a rebirth or a coming of age?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Chimeric nucleases stimulate gene targeting in human cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Therapeutic gene targeting

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Improved methods for the generation of human gene knockout and knockin cell lines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Human gene targeting by viral vectors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Intervening sequences increase efficiency of RNA 3' processing and accumulation of cytoplasmic RNA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Internal ribosome entry sites in eukaryotic mRNA molecules

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Securin is required for chromosomal stability in human cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Gene targeting using a promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of genes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Loss of ataxia telangiectasia mutated- and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

CDX2 has tumorigenic potential in the human colon cancer cell lines LOVO and SW48.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Hypoxia-inducible factor-1alpha promotes nonhypoxia-mediated proliferation in colon cancer cells and xenografts.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Targeted deletion of MKK4 in cancer cells: a detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Multiple roles for separase auto-cleavage during the G2/M transition.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Glutathione S-transferase pi1 promotes tumorigenicity in HCT116 human colon cancer cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Use of isogenic human cancer cells for high-throughput screening and drug discovery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Genetic targeting of the kinase activity of the Met receptor in cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Quantitative analysis of the packaging capacity of recombinant adeno-associated virus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Design and packaging of adeno-associated virus gene targeting vectors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Preparative and analytical purification of DNA from agarose

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Rapid purification of DNA from agarose gels by centrifugation through a disposable plastic column

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

Gene targeting in embryonic stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2007.408

31 March 2020

Identifiers

DOI

10.1038/NPROT.2007.408

1 reference

PubMed ID

18007609

Dimensions Publication ID

16 September 2017

0 references

1 reference

PubMed ID

18007609