(Q40093452)

English

MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas

scientific article published on 13 August 2007

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scholarly article

1 reference

Europe PubMed Central

17 September 2017

MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas (English)

1 reference

Europe PubMed Central

17 September 2017

hypermethylation

1 reference

based on heuristic

inferred from title

author name string

Judith W M Jeuken

1

1 reference

Europe PubMed Central

17 September 2017

Sandra J B Cornelissen

2

1 reference

Europe PubMed Central

17 September 2017

Martine Vriezen

3

1 reference

Europe PubMed Central

17 September 2017

Marieke M G Dekkers

4

1 reference

Europe PubMed Central

17 September 2017

Abdellatif Errami

5

1 reference

Europe PubMed Central

17 September 2017

Angelique Sijben

6

1 reference

Europe PubMed Central

17 September 2017

Sandra H E Boots-Sprenger

7

1 reference

Europe PubMed Central

17 September 2017

Pieter Wesseling

8

1 reference

Europe PubMed Central

17 September 2017

publication date

13 August 2007

1 reference

Europe PubMed Central

17 September 2017

Laboratory Investigation

1 reference

Europe PubMed Central

17 September 2017

87

1 reference

Europe PubMed Central

17 September 2017

1055-1065

1 reference

Europe PubMed Central

17 September 2017

10

1 reference

Europe PubMed Central

17 September 2017

https://scigraph.springernature.com/pub.10.1038/labinvest.3700664

0 references

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MGMT: its role in cancer aetiology and cancer therapeutics

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Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea

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Effect of sequence context on O(6)-methylguanine repair and replication in vivo

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DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

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CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas

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Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

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Identification and resolution of artifacts in bisulfite sequencing.

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Quantification of the methylation status of the PWS/AS imprinted region: comparison of two approaches based on bisulfite sequencing and methylation-sensitive MLPA

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Methylation-specific MLPA (MS-MLPA): simultaneous detection of CpG methylation and copy number changes of up to 40 sequences

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Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification

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Multiplex ligation-dependent probe amplification: a diagnostic tool for simultaneous identification of different genetic markers in glial tumors

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Multiplex ligation-dependent probe amplification for the detection of chromosomal gains and losses in formalin-fixed tissue

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Prognostic significance of O6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas

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Immunohistochemical study for O6-methylguanine-DNA methyltransferase in the non-neoplastic and neoplastic components of gliomas

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MGMT gene silencing and benefit from temozolomide in glioblastoma

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Variability and regulation of O6-alkylguanine-DNA alkyltransferase

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A simplified laboratory validated assay for MGMT promoter hypermethylation analysis of glioma specimens from formalin-fixed paraffin-embedded tissue.

1 reference

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Quantitative analysis of O6-alkylguanine-DNA alkyltransferase in malignant glioma.

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Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors.

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Phase II study of first-line chemotherapy with temozolomide in recurrent oligodendroglial tumors: the European Organization for Research and Treatment of Cancer Brain Tumor Group Study 26971.

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Cancer epigenetics comes of age

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Identifiers

10.1038/LABINVEST.3700664

1 reference

Europe PubMed Central

17 September 2017

1 reference

Europe PubMed Central

17 September 2017

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