(Q40122807)

English

BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts.

scientific article published on 7 June 2007

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scholarly article

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31 December 2019

BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts (English)

1 reference

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31 December 2019

3

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31 December 2019

Stefan K. Bohlander

6

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31 December 2019

author name string

Kohl TM

1

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31 December 2019

Hellinger C

2

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31 December 2019

Buske C

4

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31 December 2019

Hiddemann W

5

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31 December 2019

Spiekermann K

7

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31 December 2019

publication date

7 June 2007

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31 December 2019

1 reference

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31 December 2019

21

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31 December 2019

1763-1772

1 reference

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31 December 2019

8

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31 December 2019

https://scigraph.springernature.com/pub.10.1038/sj.leu.2404776

0 references

Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing

1 reference

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Drug therapy for acute myeloid leukemia

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Genetics of myeloid malignancies: pathogenetic and clinical implications

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Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

1 reference

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Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

1 reference

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7 January 2021

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The role of FLT3 in haematopoietic malignancies

1 reference

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7 January 2021

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FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia.

1 reference

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7 January 2021

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Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

1 reference

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7 January 2021

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FLT3 internal tandem duplication in CD34+/CD33- precursors predicts poor outcome in acute myeloid leukemia

1 reference

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7 January 2021

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Finding the next Gleevec: FLT3 targeted kinase inhibitor therapy for acute myeloid leukemia

1 reference

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7 January 2021

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Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412.

1 reference

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7 January 2021

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The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3.

1 reference

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7 January 2021

based on heuristic

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The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: the induction of cytotoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases

1 reference

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7 January 2021

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A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy

1 reference

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7 January 2021

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Generalized Equations for the Analysis of Inhibitions of Michaelis-Menten and Higher-Order Kinetic Systems with Two or More Mutually Exclusive and Nonexclusive Inhibitors

1 reference

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7 January 2021

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Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD–transformed hematopoietic cells

1 reference

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7 January 2021

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Variable cytotoxicity of diphtheria toxin 388-granulocyte-macrophage colony-stimulating factor fusion protein for acute myelogenous leukemia stem cells

1 reference

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7 January 2021

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

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7 January 2021

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Overexpression of Bax sensitizes human pancreatic cancer cells to apoptosis induced by chemotherapeutic agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404776

7 January 2021

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KIT exon 8 mutations associated with core-binding factor (CBF)-acute myeloid leukemia (AML) cause hyperactivation of the receptor in response to stem cell factor.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404776

7 January 2021

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KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404776

7 January 2021

based on heuristic

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FLT3-ITD-TKD dual mutants associated with AML confer resistance to FLT3 PTK inhibitors and cytotoxic agents by overexpression of Bcl-x(L).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404776

7 January 2021

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Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404776

7 January 2021

based on heuristic

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404776

7 January 2021

based on heuristic

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'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404776

7 January 2021

based on heuristic

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Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404776

7 January 2021

based on heuristic

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

1 reference

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7 January 2021

based on heuristic

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404776

7 January 2021

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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

1 reference

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Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

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Iressa induces cytostasis and augments Fas-mediated apoptosis in acinic cell adenocarcinoma overexpressing HER2/neu

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7 January 2021

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Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

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7 January 2021

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Synergistic effect of SU11248 with cytarabine or daunorubicin on FLT3 ITD-positive leukemic cells

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A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease

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Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia

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Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias

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A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.

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MicroRNAs as a potential magic bullet in cancer.

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1 reference

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based on heuristic

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Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis: protection is correlated with up regulation of Bcl-xL.

1 reference

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1 reference

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Identifiers

10.1038/SJ.LEU.2404776

1 reference

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31 December 2019

Dimensions Publication ID

0 references

1 reference

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31 December 2019

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