(Q40193180)

English

The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.

scientific article published on 17 December 2006

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17178724%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17178724%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

0 references

GRB2 associated binding protein 1

1 reference

GOA release 2020-03-11

endothelial cell chemotaxis to vascular endothelial growth factor

1 reference

GOA release 2020-03-11

Growth factor receptor bound protein 2-associated protein 1

1 reference

GOA release 2020-03-11

7

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23 December 2019

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Mélanie Laramée

1

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23 December 2019

Catherine Chabot

2

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23 December 2019

Monikca Cloutier

3

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23 December 2019

Raphaëlle Stenne

4

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23 December 2019

Marina Holgado-Madruga

5

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23 December 2019

Albert J Wong

6

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23 December 2019

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publication date

17 December 2006

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23 December 2019

Journal of Biological Chemistry

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23 December 2019

282

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23 December 2019

7758-7769

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23 December 2019

11

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23 December 2019

Mechanisms of angiogenesis

1 reference

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Angiogenesis in health and disease

1 reference

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21 January 2018

Vascular-specific growth factors and blood vessel formation

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21 January 2018

Angiogenic factors

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Angiogenesis in cancer, vascular, rheumatoid and other disease

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21 January 2018

Angiogenesis in cancer and other diseases

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21 January 2018

Clinical applications of angiogenic growth factors and their inhibitors

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Tumor angiogenesis: past, present and the near future

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Vascular endothelial growth factor: basic science and clinical progress

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21 January 2018

VEGF signalling: integration and multi-tasking in endothelial cell biology

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21 January 2018

Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability

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21 January 2018

Tumor metastasis but not tumor growth is dependent on Src-mediated vascular permeability

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21 January 2018

Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis

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21 January 2018

Growth factor receptor tyrosine kinases

1 reference

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21 January 2018

A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells

1 reference

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21 January 2018

Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization

1 reference

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21 January 2018

Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF-receptor

1 reference

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21 January 2018

Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues

1 reference

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21 January 2018

VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis

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21 January 2018

Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c-Src

1 reference

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21 January 2018

VEGF-receptor signal transduction

1 reference

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21 January 2018

Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice

1 reference

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21 January 2018

Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis

1 reference

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21 January 2018

Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

1 reference

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21 January 2018

Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.

1 reference

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21 January 2018

Vascular endothelial growth factor up-regulates ICAM-1 expression via the phosphatidylinositol 3 OH-kinase/AKT/Nitric oxide pathway and modulates migration of brain microvascular endothelial cells

1 reference

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21 January 2018

Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611327200

21 January 2018

The "Gab" in signal transduction.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611327200

21 January 2018

The gift of Gab.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611327200

21 January 2018

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611327200

21 January 2018

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611327200

21 January 2018

The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611327200

21 January 2018

The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611327200

21 January 2018

The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611327200

21 January 2018

Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611327200

21 January 2018

Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611327200

21 January 2018

Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611327200

21 January 2018

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells

1 reference

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21 January 2018

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

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21 January 2018

A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

1 reference

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21 January 2018

Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611327200

21 January 2018

Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.

1 reference

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21 January 2018

Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor

1 reference

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21 January 2018

Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor

1 reference

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21 January 2018

Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

1 reference

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21 January 2018

Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor

1 reference

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21 January 2018

The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase.

1 reference

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21 January 2018

The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells

1 reference

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21 January 2018

Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis

1 reference

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21 January 2018

Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

1 reference

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21 January 2018

Recruitment and activation of phospholipase Cgamma1 by vascular endothelial growth factor receptor-2 are required for tubulogenesis and differentiation of endothelial cells

1 reference

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21 January 2018

Gab1, SHP2, and protein kinase A are crucial for the activation of the endothelial NO synthase by fluid shear stress

1 reference

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21 January 2018

Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells

1 reference

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21 January 2018

Cell migration: integrating signals from front to back

1 reference

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21 January 2018

Biochemical and biological responses induced by coupling of Gab1 to phosphatidylinositol 3-kinase in RET-expressing cells

1 reference

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21 January 2018

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity

1 reference

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21 January 2018

Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion

1 reference

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21 January 2018

Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility

1 reference

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21 January 2018

The protein tyrosine phosphatase Shp-2 regulates RhoA activity

1 reference

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21 January 2018

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

1 reference

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21 January 2018

Role of the Grb2-associated binder 1/SHP-2 interaction in cell growth and transformation

1 reference

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21 January 2018

VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M611327200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17178724%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17178724%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

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