(Q40279488)

19 September 2017

Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein (English)

1 reference

19 September 2017

5

1 reference

19 September 2017

Brummer T

1

1 reference

19 September 2017

Martin P

2

1 reference

19 September 2017

Herzog S

3

1 reference

19 September 2017

Misawa Y

4

1 reference

19 September 2017

Reth M

6

1 reference

19 September 2017

language of work or name

English

0 references

publication date

15 May 2006

1 reference

19 September 2017

1 reference

19 September 2017

25

1 reference

19 September 2017

6262-6276

1 reference

19 September 2017

47

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.onc.1209640

19 September 2017

0 references

cites work

[29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

B-cell signal transduction: tyrosine phosphorylation, kinase activity, and calcium mobilization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

The requirement of specific membrane domains for Raf-1 phosphorylation and activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Regulation of Raf through phosphorylation and N terminus-C terminus interaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Positive and negative regulation of Raf kinase activity and function by phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Autoregulation of the Raf-1 serine/threonine kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Mutations of the BRAF gene in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Regulation of Raf-1 activation and signalling by dephosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Guilty as charged: B-RAF is a human oncogene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Identification of residues and domains of Raf important for function in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in response to growth factor stimulation: differential roles of 14-3-3 protein binding sites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Oncogenic mutations in B-Raf: some losses yield gains.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Different effects of point mutations within the B-Raf glycine-rich loop in colorectal tumors on mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase and nuclear factor kappaB pathway and cellul

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

B-RAF is a therapeutic target in melanoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

14-3-3 antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Disruption of the 14-3-3 binding site within the B-Raf kinase domain uncouples catalytic activity from PC12 cell differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Cancer: enzymes play molecular tag.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Conferring specificity on the ubiquitous Raf/MEK signalling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Modulation of kinase activity and oncogenic properties by alternative splicing reveals a novel regulatory mechanism for B-Raf

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

BRAF mutation predicts sensitivity to MEK inhibition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Epithelial-mesenchymal transitions in tumour progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

SPRY2 is an inhibitor of the ras/extracellular signal-regulated kinase pathway in melanocytes and melanoma cells with wild-type BRAF but not with the V599E mutant

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

The RAF proteins take centre stage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

V599EB-RAF is an oncogene in melanocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Phosphorylation of 338SSYY341 regulates specific interaction between Raf-1 and MEK1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

How do 14-3-3 proteins work?-- Gatekeeper phosphorylation and the molecular anvil hypothesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209640

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209640

1 reference

Dimensions Publication ID

19 September 2017

0 references

1 reference