(Q40328896)

19 September 2017

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation (English)

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19 September 2017

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6

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10

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19 September 2017

Sarah L Doyle

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Doug Hilton

object named as

Douglas J Hilton

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Luke A. J. O'Neill

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object named as

Luke A J O'Neill

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19 September 2017

5

Jennifer E Fenner

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19 September 2017

Rosealee Smith

2

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19 September 2017

Pearl Gray

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19 September 2017

Sandra E Nicholson

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19 September 2017

language of work or name

English

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publication date

15 January 2006

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19 September 2017

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19 September 2017

7

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19 September 2017

148-155

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19 September 2017

2

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https://scigraph.springernature.com/pub.10.1038/ni1299

19 September 2017

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7 January 2021

Adaptor usage and Toll-like receptor signaling specificity

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7 January 2021

Toll-like receptor signalling

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7 January 2021

The Toll-IL-1 receptor adaptor family grows to five members.

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7 January 2021

TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.

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7 January 2021

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF

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7 January 2021

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

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7 January 2021

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

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7 January 2021

Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4.

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7 January 2021

Negative regulation of toll-like receptor-mediated immune responses

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7 January 2021

Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors

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7 January 2021

SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling

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7 January 2021

MyD88S, a splice variant of MyD88, differentially modulates NF-kappaB- and AP-1-dependent gene expression.

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7 January 2021

Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling.

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7 January 2021

IRAK-M is a negative regulator of Toll-like receptor signaling

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7 January 2021

Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105

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7 January 2021

Structure and function of a new STAT-induced STAT inhibitor

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7 January 2021

A new protein containing an SH2 domain that inhibits JAK kinases

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7 January 2021

A family of cytokine-inducible inhibitors of signalling

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7 January 2021

The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response

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7 January 2021

SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

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7 January 2021

Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells

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7 January 2021

SOCS1/JAB is a negative regulator of LPS-induced macrophage activation

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7 January 2021

SOCS-1 participates in negative regulation of LPS responses

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7 January 2021

The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

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7 January 2021

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

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7 January 2021

PEST sequences and regulation by proteolysis

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7 January 2021

The SOCS box: a tale of destruction and degradation

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7 January 2021

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

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7 January 2021

Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice

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7 January 2021

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

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7 January 2021

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

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7 January 2021

Regulation of the transcriptional activity of the nuclear factor-kappaB p65 subunit.

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7 January 2021

Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide

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7 January 2021

Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling

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7 January 2021

Negative regulation of cytokine signaling and inflammatory diseases

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7 January 2021

Regulation of TLR signaling and inflammation by SOCS family proteins

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7 January 2021

Negative regulation of cytokine signaling: STAT-induced STAT inhibitor

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7 January 2021

Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity

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7 January 2021

Dual receptors and distinct pathways mediate interleukin-1 receptor-associated kinase degradation in response to lipopolysaccharide. Involvement of CD14/TLR4, CR3, and phosphatidylinositol 3-kinase

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7 January 2021

The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation

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7 January 2021

A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression

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7 January 2021

Identifiers

DOI

10.1038/NI1299

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Dimensions Publication ID

19 September 2017

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