(Q40379793)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16132345%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

title

Human multidrug resistance associated protein 4 confers resistance to camptothecins (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16132345%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

main subject

multiple drug resistance

1 reference

inferred from title

SN-38 carboxylate form

1 reference

ChEBI release 2020-05-28

3

1 reference

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6 January 2020

Hongyuan Yang

9

1 reference

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6 January 2020

Jinsong Bian

10

1 reference

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6 January 2020

author name string

Quan Tian

1

1 reference

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6 January 2020

Jing Zhang

2

1 reference

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6 January 2020

Eli Chan

4

1 reference

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6 January 2020

Wei Duan

5

1 reference

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6 January 2020

Sui Yung Chan

6

1 reference

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6 January 2020

Urs Alex Boelsterli

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16132345%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Paul Chi-Lui Ho

8

1 reference

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6 January 2020

Min Huang

11

1 reference

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6 January 2020

Yi-Zhun Zhu

12

1 reference

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6 January 2020

Weiping Xiong

13

1 reference

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6 January 2020

Xiaotian Li

14

1 reference

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6 January 2020

Shufeng Zhou

15

1 reference

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6 January 2020

publication date

1 November 2005

1 reference

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6 January 2020

published in

Pharmaceutical Research

1 reference

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6 January 2020

volume

22

1 reference

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6 January 2020

page(s)

1837-1853

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16132345%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

issue

11

1 reference

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Phenomenology and scientific progress.

6 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS11095-005-7595-Z

Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates

21 January 2018

1 reference

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Kinetics of lactone hydrolysis in antitumor drugs of camptothecin series as studied by fluorescence spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-005-7595-Z

A pharmacokinetic and pharmacodynamic analysis of CPT-11 and its active metabolite SN-38.

21 January 2018

1 reference

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Reduced cellular accumulation of topotecan: a novel mechanism of resistance in a human ovarian cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-005-7595-Z

Determinants of CPT-11 and SN-38 activities in human lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-005-7595-Z

Taxol transport by human intestinal epithelial Caco-2 cells.

21 January 2018

1 reference

12 December 2020

Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione.

1 reference

12 December 2020

Pharmacokinetic modulation of irinotecan and metabolites by cyclosporin A.

1 reference

12 December 2020

Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).

1 reference

12 December 2020

Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen.

1 reference

12 December 2020

pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells

1 reference

12 December 2020

The transformation of irinotecan (CPT-11) to its active metabolite SN-38 by human liver microsomes. Differential hydrolysis for the lactone and carboxylate forms.

1 reference

12 December 2020

Evidence for a polarized efflux system in CACO-2 cells capable of modulating cyclosporin A transport

1 reference

12 December 2020

Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro.

1 reference

12 December 2020

Irreversible trapping of the DNA-topoisomerase I covalent complex. Affinity labeling of the camptothecin binding site

1 reference

12 December 2020

Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia

1 reference

12 December 2020

Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus

1 reference

12 December 2020

Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats

1 reference

12 December 2020

Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells

1 reference

12 December 2020

Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5

1 reference

12 December 2020

Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist

1 reference

12 December 2020

1 reference

12 December 2020

Phase II study of irinotecan combined with cisplatin in patients with previously untreated small-cell lung cancer. West Japan Lung Cancer Group

1 reference

12 December 2020

Cross-resistance to camptothecin analogues in a mitoxantrone-resistant human breast carcinoma cell line is not due to DNA topoisomerase I alterations

1 reference

12 December 2020

Multidrug resistance and pharmacological protection mediated by the breast cancer resistance protein (BCRP/ABCG2).

1 reference

12 December 2020

Clinical pharmacokinetics of irinotecan and its metabolites: a population analysis

1 reference

12 December 2020

Topoisomerase II inhibitors

1 reference

12 December 2020

Plasma pharmacokinetics of 7-ethyl-10-hydroxycamptothecin (SN-38) after intravenous administration of SN-38 and irinotecan (CPT-11) to rats

1 reference

12 December 2020

Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells

1 reference

12 December 2020

Differential effects of the breast cancer resistance protein on the cellular accumulation and cytotoxicity of 9-aminocamptothecin and 9-nitrocamptothecin

1 reference

12 December 2020

A model for the mechanism of human topoisomerase I

1 reference

12 December 2020

Expression of multidrug resistance protein-3 (multispecific organic anion transporter-D) in human embryonic kidney 293 cells confers resistance to anticancer agents.

1 reference

12 December 2020

Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA

1 reference

12 December 2020

Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms.

1 reference

12 December 2020

Transport of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide by human intestinal Caco-2 cells

1 reference

12 December 2020

MRP3, an organic anion transporter able to transport anti-cancer drugs

1 reference

12 December 2020

Cellular, pharmacokinetic, and pharmacodynamic aspects of response to camptothecins: can we improve it?

1 reference

12 December 2020

Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues

1 reference

12 December 2020

1 reference

12 December 2020

The current status of camptothecin analogues as antitumor agents

1 reference

12 December 2020

Subcellular localization of the camptothecin analogues, topotecan and gimatecan

1 reference

12 December 2020

pH-dependent uptake of irinotecan and its active metabolite, SN-38, by intestinal cells

1 reference

12 December 2020

Intestinal transport of irinotecan in Caco-2 cells and MDCK II cells overexpressing efflux transporters Pgp, cMOAT, and MRP1.

1 reference

12 December 2020

Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export

1 reference

12 December 2020

A family of drug transporters: the multidrug resistance-associated proteins.

1 reference

12 December 2020

A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues

1 reference

12 December 2020

Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.

1 reference

12 December 2020

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1 reference

12 December 2020

Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines

1 reference

12 December 2020

Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer.

1 reference

12 December 2020

The structural basis of camptothecin interactions with human serum albumin: impact on drug stability

1 reference

12 December 2020

Enhanced clearance of topoisomerase I inhibitors from human colon cancer cells by glucuronidation

1 reference

12 December 2020

Biliary excretion mechanism of CPT-11 and its metabolites in humans: involvement of primary active transporters

1 reference

12 December 2020

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11

1 reference

12 December 2020

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

1 reference

12 December 2020

Correlations between S and G2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells.

1 reference

12 December 2020

Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.

1 reference

12 December 2020

Possible involvement of P-glycoprotein in biliary excretion of CPT-11 in rats

1 reference

12 December 2020

Differential rates of glucuronidation for 7-ethyl-10-hydroxy-camptothecin (SN-38) lactone and carboxylate in human and rat microsomes and recombinant UDP-glucuronosyltransferase isoforms

1 reference

12 December 2020

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic evaluation of the topoisomerase inhibitor irinotecan in cancer patients.

1 reference

12 December 2020

High-performance liquid chromatographic procedures for the quantitative determination of paclitaxel (Taxol) in human urine

1 reference

12 December 2020

The intestinal absorption of camptothecin, a highly lipophilic drug, across Caco-2 cells is mediated by active transporter(s)

1 reference

12 December 2020

Modulation by acrolein and chloroacetaldehyde of multidrug resistance mediated by the multidrug resistance-associated protein (MRP).

1 reference

12 December 2020

Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione.

1 reference

12 December 2020

Phase II trial of 9-nitrocamptothecin (RFS 2000) for patients with metastatic cutaneous or uveal melanoma

1 reference

12 December 2020

Cytokines Alter the Expression and Activity of the Multidrug Resistance Transporters in Human Hepatoma Cell Lines; Analysis Using RT‐PCR and cDNA Microarrays

1 reference

12 December 2020

Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian cancer

1 reference

12 December 2020

Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats

1 reference

12 December 2020

Active efflux of CPT-11 and its metabolites in human KB-derived cell lines

1 reference

12 December 2020

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.

1 reference

12 December 2020

Mammalian ABC transporters in health and disease

1 reference

12 December 2020

Phase II trial of oral rubitecan in previously treated pancreatic cancer patients

1 reference

12 December 2020

Kinetics of the in vivo interconversion of the carboxylate and lactone forms of irinotecan (CPT-11) and of its metabolite SN-38 in patients

1 reference

12 December 2020

Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.

1 reference

12 December 2020

CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells

1 reference

12 December 2020

A human T lymphoid cell variant resistant to the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine shows a unique combination of a phosphorylation defect and increased efflux of the agent

1 reference

12 December 2020

Mechanisms of resistance to topoisomerase I-targeting drugs

1 reference

12 December 2020

Resistance to mitoxantrone in multidrug-resistant MCF7 breast cancer cells: evaluation of mitoxantrone transport and the role of multidrug resistance protein family proteins

1 reference

12 December 2020

Influence of IL-6 on MDR and MRP-mediated multidrug resistance in human hepatoma cells.

1 reference

12 December 2020

Cyclooxygenase-2 inhibition with celecoxib enhances antitumor efficacy and reduces diarrhea side effect of CPT-11.

1 reference

12 December 2020

ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages.

1 reference

12 December 2020

Mrp4 confers resistance to topotecan and protects the brain from chemotherapy

1 reference

12 December 2020

10.1007/S11095-005-7595-Z

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16132345%20AND%20SRC:MED&resulttype=core&format=json

release_5zhxa7najvecrd7uugrtkkbpku

6 January 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/5zhxa7najvecrd7uugrtkkbpku

24 November 2022

mapped directly with Wikidata item

1 reference