(Q40403954)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15985433%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

title

Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells (English)

1 reference

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13 January 2020

0 references

1 reference

2

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13 January 2020

Lorenza Tacchini

3

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13 January 2020

Alessandro Campanella

5

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13 January 2020

Gaetano Cairo

6

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13 January 2020

author name string

Alessandra Alberghini

1

1 reference

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13 January 2020

Paolo Santambrogio

4

1 reference

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13 January 2020

language of work or name

English

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publication date

28 June 2005

1 reference

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Journal of Biological Chemistry

13 January 2020

published in

1 reference

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13 January 2020

volume

280

1 reference

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13 January 2020

page(s)

30120-30128

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13 January 2020

issue

34

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describes a project that uses

13 January 2020

RCC10

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RCC63

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cites work

Balancing acts: molecular control of mammalian iron metabolism

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The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage.

21 January 2018

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The ferritins: molecular properties, iron storage function and cellular regulation

21 January 2018

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Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress

21 January 2018

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Iron regulatory proteins in pathobiology.

21 January 2018

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The iron metabolism of neoplastic cells: alterations that facilitate proliferation?

21 January 2018

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Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC

21 January 2018

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The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer

21 January 2018

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Hypoxia--a key regulatory factor in tumour growth

21 January 2018

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The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.

21 January 2018

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Targeting HIF-1 for cancer therapy

21 January 2018

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Investigating hypoxic tumor physiology through gene expression patterns

21 January 2018

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HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation

21 January 2018

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Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

21 January 2018

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Doxorubicin paradoxically protects cardiomyocytes against iron-mediated toxicity: role of reactive oxygen species and ferritin

21 January 2018

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Purification and characterization of hypoxia-inducible factor 1

21 January 2018

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Molecular basis of reduced albumin gene expression in hepatoma cell lines with different growth rates

21 January 2018

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Analysis of the biologic functions of H- and L-ferritins in HeLa cells by transfection with siRNAs and cDNAs: evidence for a proliferative role of L-ferritin

21 January 2018

1 reference

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Human mitochondrial ferritin expressed in HeLa cells incorporates iron and affects cellular iron metabolism

21 January 2018

1 reference

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Preferential activation of iron regulatory protein-2 in cell lines as a result of higher sensitivity to iron.

21 January 2018

1 reference

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Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis

21 January 2018

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HIF-1 and mechanisms of hypoxia sensing

21 January 2018

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Oxygen and iron regulation of iron regulatory protein 2.

21 January 2018

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Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity

21 January 2018

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Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis

21 January 2018

1 reference

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Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene

21 January 2018

1 reference

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Fibronectin is a hypoxia-independent target of the tumor suppressor VHL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500971200

Characterization and expression of iron regulatory protein 2 (IRP2). Presence of multiple IRP2 transcripts regulated by intracellular iron levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500971200

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500971200

Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2

21 January 2018

1 reference

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The pathway for IRP2 degradation involving 2-oxoglutarate-dependent oxygenase(s) does not require the E3 ubiquitin ligase activity of pVHL.

21 January 2018

1 reference

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Anthracyclines induce accumulation of iron in ferritin in myocardial and neoplastic cells: inhibition of the ferritin iron mobilization pathway

21 January 2018

1 reference

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Examination of the mechanism(s) involved in doxorubicin-mediated iron accumulation in ferritin: studies using metabolic inhibitors, protein synthesis inhibitors, and lysosomotropic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500971200

Modulation of cellular iron metabolism by hydrogen peroxide. Effects of H2O2 on the expression and function of iron-responsive element-containing mRNAs in B6 fibroblasts

21 January 2018

1 reference

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New insights into an enigmatic tumour suppressor

21 January 2018

1 reference

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Tumor suppressor protein VHL is induced at high cell density and mediates contact inhibition of cell growth

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M500971200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15985433%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

1 reference