(Q40445871)

20 September 2017

Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. (English)

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20 September 2017

Richard I Feldman

1

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20 September 2017

James M Wu

2

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20 September 2017

Mark A Polokoff

3

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20 September 2017

Monica J Kochanny

4

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20 September 2017

Harald Dinter

5

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20 September 2017

Daguang Zhu

6

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20 September 2017

Sandra L Biroc

7

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20 September 2017

Bruno Alicke

8

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20 September 2017

Judi Bryant

9

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20 September 2017

Shendong Yuan

10

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20 September 2017

Brad O Buckman

11

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20 September 2017

Dao Lentz

12

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20 September 2017

Mike Ferrer

13

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20 September 2017

Marc Whitlow

14

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20 September 2017

Marc Adler

15

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20 September 2017

Silke Finster

16

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20 September 2017

Zheng Chang

17

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20 September 2017

Damian O Arnaiz

18

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20 September 2017

language of work or name

English

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publication date

16 March 2005

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Journal of Biological Chemistry

20 September 2017

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20 September 2017

280

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20 September 2017

19867-19874

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20 September 2017

20

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PDK1, the master regulator of AGC kinase signal transduction

20 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

The Akt pathway: molecular targets for anti-cancer drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Structure, regulation and function of PKB/AKT--a major therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Role of Akt signaling in vascular homeostasis and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

PI 3-kinase, Akt and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

The biology and clinical relevance of the PTEN tumor suppressor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

PTEN: life as a tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Unravelling the activation mechanisms of protein kinase B/Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Calpha in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Ribosomal S6 kinase signaling and the control of translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

TSC2: filling the GAP in the mTOR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Phosphorylation and activation of p70s6k by PDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4,6-bis anilino pyrimidines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinasein Vivoat Thr-412 as well as Thr-252

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501367200

21 January 2018

Identifiers

DOI

10.1074/JBC.M501367200

1 reference

20 September 2017

1 reference