(Q40463530)

20 September 2017

1 reference

title

Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury. (English)

1 reference

20 September 2017

S D Nelson

1

1 reference

PubMed ID

7641574

20 September 2017

language of work or name

English

0 references

publication date

1 January 1995

1 reference

20 September 2017

Drug Metabolism Reviews

1 reference

20 September 2017

27

1 reference

20 September 2017

147-177

1 reference

20 September 2017

1-2

1 reference

The role of metabolic activation in drug toxicity

20 September 2017

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Reactive intermediates and their toxicological significance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Role of Covalent and Noncovalent Interactions in Cell Toxicity: Effects on Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

An immunochemical approach of identifying and characterizing protein targets of toxic reactive metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Molecular mechanisms of the hepatotoxicity caused by acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Evidence for the involvement of N-acetyl-p- quinoneimine in acetaminophen metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Cytochrome P-450 isozyme selectivity in the oxidation of acetaminophen.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Cytotoxic effects of N-acetyl-p-benzoquinone imine, a common arylating intermediate of paracetamol and N-hydroxyparacetamol

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Severe acetaminophen toxicity in a patient receiving isoniazid

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Inhibition and induction of cytochrome P4502E1-catalyzed oxidation by isoniazid in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Hepatotoxicity associated with acetaminophen usage in patients receiving multiple drug therapy for tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Metabolism of 2-acetylaminofluorene by eight different forms of cytochrome P-450 isolated from rat liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Preferred orientations in the binding of 4'-hydroxyacetanilide (acetaminophen) to cytochrome P450 1A1 and 2B1 isoforms as determined by 13C- and 15N-NMR relaxation studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Cytochrome P-450 catalysis: radical intermediates and dehydrogenation reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

The involvement of free radicals in the mechanisms of monooxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

In vitro effects of acetaminophen metabolites and analogs on the respiration of mouse liver mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Comparative cytotoxic effects of acetaminophen (N-acetyl-p-aminophenol), a non-hepatotoxic regioisomer acetyl-m-aminophenol and their postulated reactive hydroquinone and quinone metabolites in monolayer cultures of mouse hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Experimental paracetamol-induced hepatic necrosis: A light-and electron-microscope, and histochemical study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Impaired mitochondrial oxidative energy metabolism following paracetamol-induced hepatotoxicity in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

A metabolite of acetaminophen covalently binds to the 56 kDa selenium binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Purification, antibody production, and partial amino acid sequence of the 58-kDa acetaminophen-binding liver proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Paracetamol-induced hepatic necrosis in the mouse-relationship between covalent binding, hepatic glutathione depletion and the protective effect of alpha-mercaptopropionylglycine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Reversal of acetaminophen toxicity in isolated hamster hepatocytes by dithiothreitol.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

The spontaneous and enzymatic reaction of N-acetyl-p-benzoquinonimine with glutathione: A stopped-flow kinetic study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Paracetamol-stimulated lipid peroxidation in isolated rat and mouse hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Superoxide dismutase and catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Lipid peroxidation, protein synthesis, and protection by calcium EDTA in paracetamol injury to isolated hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

On the role of Ca2+ in the toxicity of alkylating and oxidizing quinone imines in isolated hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Effects of calcium channel blocking agents on calcium and centrilobular necrosis in the liver of rats treated with hepatotoxic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

The role of the nucleus and other compartments in toxic cell death produced by alkylating hepatotoxicants

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Potential Value of Plants As Sources of New Antifertility Agents I *

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Pennyroyal Oil Poisoning and Hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Hepatotoxicity and pulmonary toxicity of pennyroyal oil and its constituent terpenes in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Hepatotoxicity of pulegone in rats: its effects on microsomal enzymes, in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Metabolism of a monoterpene ketone, R-(+)-pulegone--a hepatotoxin in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Investigations of mechanisms of reactive metabolite formation from (R)-(+)-pulegone

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Reactive intermediates in the oxidation of menthofuran by cytochromes P-450

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Carbon tetrachloride hepatotoxicity: an example of free radical-mediated injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

The contribution of bromobenzene to our current understanding of chemically-induced toxicities

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

Immunochemical detection of oxidized proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539509029821

10.3109/03602539509029821

21 January 2018

Identifiers

DOI

1 reference

20 September 2017

1 reference

PubMed ID

7641574