(Q40473008)

20 September 2017

Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex. (English)

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20 September 2017

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6

Len Neckers

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20 September 2017

4

Edward Mimnaugh

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20 September 2017

Wanping Xu

1

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20 September 2017

Xitong Yuan

series ordinal

2

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20 September 2017

Zhexin Xiang

series ordinal

3

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20 September 2017

Monica Marcu

series ordinal

5

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20 September 2017

language of work or name

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9 January 2005

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Nature Structural & Molecular Biology

20 September 2017

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20 September 2017

12

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20 September 2017

120-126

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20 September 2017

2

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https://scigraph.springernature.com/pub.10.1038/nsmb885

20 September 2017

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cites work

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The assembly and intermolecular properties of the hsp70-Hop-hsp90 molecular chaperone complex

31 March 2020

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Visualization and mechanism of assembly of a glucocorticoid receptor.Hsp70 complex that is primed for subsequent Hsp90-dependent opening of the steroid binding cleft

31 March 2020

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Stimulation of the weak ATPase activity of human hsp90 by a client protein

31 March 2020

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Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1

31 March 2020

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The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation

31 March 2020

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Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

31 March 2020

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31 March 2020

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Modulation of Akt kinase activity by binding to Hsp90

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Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.

31 March 2020

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Functional Dissection of Cdc37: Characterization of Domain Structure and Amino Acid Residues Critical for Protein Kinase Binding

31 March 2020

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Identification of a conserved sequence motif that promotes Cdc37 and cyclin D1 binding to Cdk4.

31 March 2020

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Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

31 March 2020

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Geldanamycin induces ErbB-2 degradation by proteolytic fragmentation

31 March 2020

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Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy

31 March 2020

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Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

31 March 2020

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

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A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase.

31 March 2020

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The role of HER2 in angiogenesis

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Genetic instability favoring transversions associated with ErbB2-induced mammary tumorigenesis

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Overexpression of HER-2 as a resistance mechanism to hormonal therapy for breast cancer

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Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers

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Transferring substrates to the 26S proteasome.

31 March 2020

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Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor

31 March 2020

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Hsp90, not Grp94, regulates the intracellular trafficking and stability of nascent ErbB2

31 March 2020

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Heat shock protein 90 as a molecular target for cancer therapeutics

31 March 2020

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Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions

31 March 2020

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High Affinity Binding of Hsp90 Is Triggered by Multiple Discrete Segments of Its Kinase Clients

31 March 2020

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CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37.

31 March 2020

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Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.

31 March 2020

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p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

31 March 2020

1 reference

On the role of structural information in remote homology detection and sequence alignment: new methods using hybrid sequence profiles

31 March 2020

1 reference

Extending the accuracy limits of prediction for side-chain conformations

31 March 2020

1 reference

Evaluating conformational free energies: the colony energy and its application to the problem of loop prediction

31 March 2020

1 reference

An integrated approach to the analysis and modeling of protein sequences and structures. III. A comparative study of sequence conservation in protein structural families using multiple structural alignments.

31 March 2020

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NSMB885

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20 September 2017

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