(Q40514016)

21 September 2017

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title

The biology of the P-glycoproteins (English)

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21 September 2017

C R Leveille-Webster

1

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PubMed ID

7731035

21 September 2017

I M Arias

series ordinal

2

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21 September 2017

1 January 1995

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21 September 2017

14

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Journal of Membrane Biology

inferred from page(s)

published in

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21 September 2017

143

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21 September 2017

89-102

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21 September 2017

2

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https://scigraph.springernature.com/pub.10.1007/bf00234655

21 September 2017

0 references

cites work

Coordinate activation of multidrug-resistance (P-glycoprotein) genesmdr2 andmdr3 during mouse liver regeneration

1 reference

12 December 2020

Structure and expression of the human MDR (P-glycoprotein) gene family

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12 December 2020

Multidrug resistance mediated by P-glycoproteins

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12 December 2020

Study of membrane orientation and glycosylated extracellular loops of mouse P-glycoprotein by in vitro translation

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12 December 2020

TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective

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12 December 2020

The multidrug resistance (mdr1) gene product functions as an ATP channel

1 reference

12 December 2020

P-glycoprotein as multidrug transporter: a critical review of current multidrug resistant cell lines

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12 December 2020

Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus

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12 December 2020

A phase II study of epidoxorubicin in colorectal cancer and the use of cyclosporin-A in an attempt to reverse multidrug resistance

1 reference

12 December 2020

Deletion and insertion mutants of the multidrug transporter.

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12 December 2020

Increased mdr-1/P-glycoprotein expression after treatment of human colon carcinoma cells with P-glycoprotein antagonists.

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12 December 2020

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

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12 December 2020

Mutations in the 70K peroxisomal membrane protein gene in Zellweger syndrome

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12 December 2020

Peptide transport by the multidrug resistance pump

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12 December 2020

Overexpression of the MDR1 gene and P-glycoprotein in human hepatocellular carcinoma

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12 December 2020

Characterization of the azidopine and vinblastine binding site of P-glycoprotein

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12 December 2020

Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals.

1 reference

12 December 2020

Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells

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12 December 2020

Multidrug-resistance phenotype in Chinese hamster ovary cells

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12 December 2020

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

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12 December 2020

Expression of P-glycoprotein gene in marine sponges. Identification and characterization of the 125 kDa drug-binding glycoprotein

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12 December 2020

Clinical modulation of doxorubicin resistance by the calmodulin-inhibitor, trifluoperazine: a phase I/II trial

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12 December 2020

MDR1 transcript levels as an indication of resistant disease in acute myelogenous leukaemia.

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12 December 2020

Progesterone photoaffinity labels P-glycoprotein in multidrug-resistant human leukemic lymphoblasts

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12 December 2020

Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

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12 December 2020

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

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12 December 2020

Contribution of the Leishmania P-glycoprotein-related gene ltpgpA to oxyanion resistance.

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12 December 2020

Assembly of the endoplasmic reticulum phospholipid bilayer: the phosphatidylcholine transporter

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12 December 2020

Molecular characterization of the ldmdr1 multidrug resistance gene from Leishmania donovani

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12 December 2020

Expression of P-glycoprotein and glutathione-S-transferase in recurrent lymphomas: the possible role of Epstein-Barr virus, immunophenotypes, and other predisposing factors

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12 December 2020

P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil

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12 December 2020

The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa

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12 December 2020

Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

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12 December 2020

Transport properties of P-glycoprotein in plasma membrane vesicles from multidrug-resistant Chinese hamster ovary cells

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12 December 2020

The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo

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12 December 2020

Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia

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12 December 2020

Reduced mRNA levels for the multidrug-resistance genes in cAMP-dependent protein kinase mutant cell lines

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12 December 2020

Cytoplasmic orientation and two-domain structure of the multidrug transporter, P-glycoprotein, demonstrated with sequence-specific antibodies

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12 December 2020

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

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12 December 2020

Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis

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12 December 2020

Targeted disruption of the mouse mdr1b gene reveals that steroid hormones enhance mdr gene expression.

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12 December 2020

Modulation of multidrug resistance: at the threshold

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12 December 2020

Expression of a multidrug resistance gene in human cancers

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12 December 2020

ATP/Mg2+-dependent binding of vincristine to the plasma membrane of multidrug-resistant K562 cells.

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12 December 2020

Functional analysis of chimeric genes obtained by exchanging homologous domains of the mouse mdr1 and mdr2 genes

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12 December 2020

Gene SNQ2 of Saccharomyces cerevisiae, which confers resistance to 4-nitroquinoline-N-oxide and other chemicals, encodes a 169 kDa protein homologous to ATP-dependent permeases

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12 December 2020

Cloning and characterization of a member of the rat multidrug resistance (mdr) gene family

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12 December 2020

Cloning and functional analysis of an extrachromosomally amplified multidrug resistance-like gene in Leishmania enriettii

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12 December 2020

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells

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12 December 2020

A P-glycoprotein homologue of Plasmodium falciparum is localized on the digestive vacuole

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12 December 2020

Expression of mdr-1/P-glycoprotein in human neuroblastoma

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12 December 2020

Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16

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12 December 2020

Reconstitution of drug-stimulated ATPase activity following co-expression of each half of human P-glycoprotein as separate polypeptides

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12 December 2020

Purification of P-glycoprotein from plasma membrane vesicles of Chinese hamster ovary cell mutants with reduced colchicine permeability

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12 December 2020

Biochemistry of multidrug resistance mediated by the multidrug transporter

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12 December 2020

Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

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12 December 2020

Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum

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12 December 2020

Human P-glycoprotein transports cyclosporin A and FK506.

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12 December 2020

Phorbol esters induce multidrug resistance in human breast cancer cells

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12 December 2020

The effects of lipids and detergents on ATPase-active P-glycoprotein

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12 December 2020

Heavy metal tolerance in the fission yeast requires an ATP-binding cassette-type vacuolar membrane transporter

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12 December 2020

P-glycoprotein expression during tumor progression in the rat liver

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12 December 2020

MDR1 gene expression and treatment outcome in acute myeloid leukemia.

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12 December 2020

MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters.

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12 December 2020

ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

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12 December 2020

Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators

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12 December 2020

Transfection with protein kinase C alpha confers increased multidrug resistance to MCF-7 cells expressing P-glycoprotein

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12 December 2020

Phase I trial of etoposide with cyclosporine as a modulator of multidrug resistance

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12 December 2020

Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.

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12 December 2020

Kinetics of daunorubicin transport by P-glycoprotein of intact cancer cells

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12 December 2020

A Fickian diffusion transport process with features of transport catalysis. Doxorubicin transport in human red blood cells

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12 December 2020

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis

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12 December 2020

MDR1 (multidrug resistance) gene expression in human primary liver cancer and cirrhosis

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12 December 2020

Progesterone regulates the murine multidrug resistance mdr1b gene.

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12 December 2020

Regulation by phorbol ester and protein kinase C inhibitors, and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human KB cells

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12 December 2020

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

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12 December 2020

Cortisol is transported by the multidrug resistance gene product P-glycoprotein

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12 December 2020

Identification of distinct P-glycoprotein gene sequences in rat

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12 December 2020

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

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12 December 2020

Reversal of multidrug resistance

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12 December 2020

Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells

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12 December 2020

Is the multidrug transporter a flippase?

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12 December 2020

Regulation of mdr RNA levels in response to cytotoxic drugs in rodent cells

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12 December 2020

Investigation of the relationship between altered intracellular pH and multidrug resistance in mammalian cells

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12 December 2020

Expression of a multidrug resistance gene in esophageal adenocarcinoma. Correlation with response to chemotherapy and comparison with gastric adenocarcinoma.

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12 December 2020

Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood

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12 December 2020

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12 December 2020

The multidrug transporter, a double-edged sword

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12 December 2020

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles.

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12 December 2020

Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters

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12 December 2020

Modulation of P-glycoprotein-mediated drug transport by alterations in lipid fluidity of rat liver canalicular membrane vesicles

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12 December 2020

Characterization of the adenosine triphosphatase activity of Chinese hamster P-glycoprotein.

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12 December 2020

Expression of a drug resistance gene in human neuroblastoma cell lines: modulation by retinoic acid-induced differentiation

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12 December 2020

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

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12 December 2020

Analysis of the steady-state and initial rate of doxorubicin efflux from a series of multidrug-resistant cells expressing different levels of P-glycoprotein

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12 December 2020

Coinduction of MDR-1 multidrug-resistance and cytochrome P-450 genes in rat liver by xenobiotics.

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12 December 2020

Progesterone interacts with P-glycoprotein in multidrug-resistant cells and in the endometrium of gravid uterus

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12 December 2020

Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells

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12 December 2020

Essential features of the P-glycoprotein pharmacophore as defined by a series of reserpine analogs that modulate multidrug resistance

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12 December 2020

Prediction of doxorubicin resistance in vitro in myeloma, lymphoma, and breast cancer by P-glycoprotein staining

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12 December 2020

Photoaffinity substrates for P-glycoprotein

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12 December 2020

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

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12 December 2020

The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression

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12 December 2020

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12 December 2020

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

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12 December 2020

Pharmacology of drugs that alter multidrug resistance in cancer

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12 December 2020

Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies

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12 December 2020

Bile acid inhibition of P-glycoprotein-mediated transport in multidrug-resistant cells and rat liver canalicular membrane vesicles

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12 December 2020

Cloning by gene amplification of two loci conferring multiple drug resistance in Saccharomyces

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12 December 2020

Isolation and characterization of Drosophila multidrug resistance gene homologs

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12 December 2020

Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia

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12 December 2020

Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene

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12 December 2020

P-glycoprotein-associated Cl- currents are activated by cell swelling but do not contribute to cell volume regulation

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12 December 2020

Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver.

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12 December 2020

Expression of the MDR1 gene in human gastric and colorectal carcinomas

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12 December 2020

ABC transporters: bacterial exporters

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12 December 2020

Characterization of a membrane-associated protein kinase of multidrug-resistant HL60 cells which phosphorylates P-glycoprotein.

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12 December 2020

Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells.

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12 December 2020

Analysis of P-glycoprotein phosphorylation in HL60 cells isolated for resistance to vincristine

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12 December 2020

Multidrug resistance phenotype of human BRO melanoma cells transfected with a wild-type human mdr1 complementary DNA.

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12 December 2020

Inhibition by cyclosporin A of adenosine triphosphate-dependent transport from the hepatocyte into bile

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12 December 2020

P-glycoprotein regulates chemosensitivity in early developmental stages of the mouse.

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12 December 2020

Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.

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12 December 2020

Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins

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12 December 2020

Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas

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12 December 2020

Phase I/pharmacokinetic study of high-dose progesterone and doxorubicin

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12 December 2020

ABC Transporters: From Microorganisms to Man

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12 December 2020

Expression of multidrug resistance genes in rat liver during regeneration and after carbon tetrachloride intoxication.

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12 December 2020

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

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12 December 2020

Continued expression of vinca alkaloid resistance by CCRF-CEM cells after treatment with tunicamycin or pronase.

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12 December 2020

Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein

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12 December 2020

mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies

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12 December 2020

Identification of specific sites in human P-glycoprotein phosphorylated by protein kinase C.

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12 December 2020

Clinical Relevance of Immunohistochemical Detection of Multidrug Resistance P-Glycoprotein in Breast Carcinoma

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12 December 2020

P-glycoprotein. ATP hydrolysis by the N-terminal nucleotide-binding domain

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12 December 2020

Covalent inhibitors of P-glycoprotein ATPase activity

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12 December 2020

Functional expression of P-glycoproteins in secretory vesicles.

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12 December 2020

Modulation of multidrug resistance gene expression in rat hepatocytes maintained under various culture conditions

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12 December 2020

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

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12 December 2020

Functional involvement of P-glycoprotein in blood-brain barrier

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12 December 2020

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus

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12 December 2020

Expression of a multidrug-resistance gene in human tumors and tissues

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12 December 2020

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities

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12 December 2020

Characterization of the multidrug resistance protein expressed in cell clones stably transfected with the mouse mdr1 cDNA.

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12 December 2020

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase

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12 December 2020

P-Glycoprotein Expression as a Predictor of the Outcome of Therapy for Neuroblastoma

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12 December 2020

Clinical correlates of MDR1 (P-glycoprotein) gene expression in ovarian and small-cell lung carcinomas

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12 December 2020

Heavy metal resistance: a new role for P-glycoproteins in Leishmania

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12 December 2020

Modulation of multidrug resistance gene expression by dexamethasone in cultured hepatoma cells

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12 December 2020

A leptomycin B resistance gene of Schizosaccharomyces pombe encodes a protein similar to the mammalian P-glycoproteins

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12 December 2020

Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells

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12 December 2020

Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis

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12 December 2020

Multidrug resistance and chemosensitization: therapeutic implications for cancer chemotherapy.

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12 December 2020

Multidrug resistance gene (P-glycoprotein) expression in the human fetus

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12 December 2020

Levels of expression of the mdr1 gene and glutathione S-transferase genes 2 and 3 and response to chemotherapy in multiple myeloma

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12 December 2020

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

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12 December 2020

The biochemistry of P-glycoprotein-mediated multidrug resistance

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12 December 2020

N-glycosylation and deletion mutants of the human MDR1 P-glycoprotein

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12 December 2020

Correlation of protein kinase C translocation, P-glycoprotein phosphorylation and reduced drug accumulation in multidrug resistant human KB cells

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12 December 2020

The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein superfamily

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12 December 2020

Volume-sensitive chloride currents in four epithelial cell lines are not directly correlated to the expression of the MDR-1 gene.

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12 December 2020

Modulation of the expression of a multidrug resistance gene (mdr-1/P-glycoprotein) by differentiating agents.

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12 December 2020

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine

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12 December 2020

Cloning and characterization of a second member of the mouse mdr gene family

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12 December 2020

Synthetic and natural opiates interact with P-glycoprotein in multidrug-resistant cells.

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12 December 2020

Identification of members of the P-glycoprotein multigene family

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12 December 2020

Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein

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12 December 2020

Activity of the multidrug transporter results in alkalinization of the cytosol: measurement of cytosolic pH by microinjection of a pH-sensitive dye

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12 December 2020

Phosphorylation of the multidrug resistance associated glycoprotein.

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12 December 2020

Detection of multidrug resistance (MDR1) gene RNA expression in human tumors by a sensitive ribonuclease protection assay

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12 December 2020

Intracellular pH and the control of multidrug resistance

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12 December 2020

Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine

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12 December 2020

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

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12 December 2020

Emetine-resistant mutants of Entamoeba histolytica overexpress mRNAs for multidrug resistance

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12 December 2020

Identification of the major phosphorylation domain of murine mdr1b P-glycoprotein. Analysis of the protein kinase A and protein kinase C phosphorylation sites.

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12 December 2020

Cyclosporins as drug resistance modifiers

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12 December 2020

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells

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12 December 2020

Cyclic AMP-dependent protein kinase regulates sensitivity of cells to multiple drugs

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12 December 2020

Evidence for an alternate model of human P-glycoprotein structure and biogenesis

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12 December 2020

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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12 December 2020

Detection of oligomeric and monomeric forms of P-glycoprotein in multidrug resistant cells

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12 December 2020

ATPase activity of purified and reconstituted P-glycoprotein from Chinese hamster ovary cells.

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12 December 2020

Interaction of multidrug-resistant Chinese hamster ovary cells with the peptide ionophore gramicidin D

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12 December 2020

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone

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12 December 2020

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

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12 December 2020

Relationships between rhodamine 123 transport, cell volume, and ion-channel function of P-glycoprotein

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12 December 2020

Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates.

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12 December 2020

Fluorescent cellular indicators are extruded by the multidrug resistance protein.

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12 December 2020

Evidence for the presence of a phosphatidylcholine translocator in isolated rat liver canalicular plasma membrane vesicles

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12 December 2020

ATP-binding properties of P glycoprotein from multidrug-resistant KB cells.

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12 December 2020

Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas

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12 December 2020

Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance

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12 December 2020

Identifiers

DOI

10.1007/BF00234655

1 reference

21 September 2017

1 reference

PubMed ID

7731035