(Q40565084)

21 September 2017

Glucagon-like peptide-1 prevents beta cell glucolipotoxicity (English)

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21 September 2017

J Buteau

1

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21 September 2017

W El-Assaad

2

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21 September 2017

C J Rhodes

3

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21 September 2017

L Rosenberg

4

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21 September 2017

E Joly

5

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21 September 2017

M Prentki

6

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21 September 2017

17 April 2004

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21 September 2017

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21 September 2017

47

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21 September 2017

806-815

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21 September 2017

5

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https://scigraph.springernature.com/pub.10.1007/s00125-004-1379-6

21 September 2017

0 references

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12 December 2020

NF-kappaB in neuronal plasticity and neurodegenerative disorders

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12 December 2020

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1

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12 December 2020

Glucose Down-regulates the Expression of the Peroxisome Proliferator-activated Receptor-α Gene in the Pancreatic β-Cell

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12 December 2020

Identification of two NF-kappa B sites in mouse CD95 ligand (Fas ligand) promoter: functional analysis in T cell hybridoma.

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12 December 2020

An integrated view of beta-cell dysfunction in type-II diabetes

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12 December 2020

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

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12 December 2020

An essential role for nuclear factor kappa B in preventing TNF-alpha-induced cell death in prostate cancer cells

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12 December 2020

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12 December 2020

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

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12 December 2020

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

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12 December 2020

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

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12 December 2020

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.

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12 December 2020

Tumor necrosis factor-alpha-induced apoptosis in prostate cancer cells through inhibition of nuclear factor-kappaB by an IkappaBalpha "super-repressor"

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12 December 2020

cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells

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12 December 2020

Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels

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12 December 2020

Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Ikappa B repressor

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12 December 2020

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

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12 December 2020

Glucose and glucoincretin peptides synergize to induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic beta(INS-1) cells.

1 reference

12 December 2020

Mechanisms of the stimulation of insulin release by saturated fatty acids. A study of palmitate effects in mouse beta-cells

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12 December 2020

Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

1 reference

12 December 2020

Nuclear Factor κB Protects Pancreatic β-Cells From Tumor Necrosis Factor-α-Mediated Apoptosis

1 reference

12 December 2020

Essentiality of intron control in the induction of c-fos by glucose and glucoincretin peptides in INS-1 beta-cells

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12 December 2020

Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration

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12 December 2020

New insights into the role of nuclear factor-kB in cell growth regulation

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12 December 2020

Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes

1 reference

12 December 2020

High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program

1 reference

12 December 2020

Glucagon-like peptide-I and the control of insulin secretion in the normal state and in NIDDM.

1 reference

12 December 2020

Activators and target genes of Rel/NF-kappaB transcription factors

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12 December 2020

Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor

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12 December 2020

Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37).

1 reference

12 December 2020

Integrative mitogenic role of protein kinase B/Akt in beta-cells.

1 reference

12 December 2020

Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells

1 reference

12 December 2020

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

1 reference

12 December 2020

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity

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12 December 2020

Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide.

1 reference

12 December 2020

cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37)

1 reference

12 December 2020

Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells

1 reference

12 December 2020

NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition

1 reference

12 December 2020

Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose

1 reference

12 December 2020

New insights into pancreatic beta-cell metabolic signaling in insulin secretion

1 reference

12 December 2020

Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells

1 reference

12 December 2020

NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1 reference

12 December 2020

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion

1 reference

12 December 2020

Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis

1 reference

12 December 2020

Serine/threonine protein kinases and apoptosis.

1 reference

12 December 2020

Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus

1 reference

12 December 2020

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

1 reference

12 December 2020

Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1)

1 reference

12 December 2020

Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5'-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway

1 reference

12 December 2020

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

1 reference

12 December 2020

Multiple NF-kappaB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene

1 reference

12 December 2020

Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation

1 reference

12 December 2020

Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation

1 reference

12 December 2020

NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.

1 reference

12 December 2020

Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop

1 reference

12 December 2020

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

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12 December 2020

Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes

1 reference

12 December 2020

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

1 reference

12 December 2020

Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats.

1 reference

12 December 2020

Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1.

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12 December 2020

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.

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12 December 2020

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

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12 December 2020

Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

1 reference

12 December 2020

Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1.

1 reference

12 December 2020

Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

1 reference

12 December 2020

Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis

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12 December 2020

Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

1 reference

12 December 2020

Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor

1 reference

12 December 2020

Insulin-promoter-factor 1 is required for pancreas development in mice

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12 December 2020

Minireview: the glucagon-like peptides

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12 December 2020

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

1 reference

12 December 2020

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

1 reference

12 December 2020

10.1007/S00125-004-1379-6

Identifiers

DOI

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21 September 2017

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