(Q40569985)

21 September 2017

1 reference

title

Processing of Alzheimer A beta-amyloid precursor protein: cell biology, regulation, and role in Alzheimer disease (English)

1 reference

21 September 2017

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2

Greengard P

1 reference

21 September 2017

Gandy S

1

1 reference

21 September 2017

publication date

1 January 1994

1 reference

International Review of Neurobiology

21 September 2017

published in

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21 September 2017

volume

36

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21 September 2017

page(s)

29-50

1 reference

Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

21 September 2017

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Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum

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Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.

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Morphological differentiation and proteoglycan synthesis regulate Alzheimer amyloid precursor protein processing in PC-12 and human astrocyte cultures

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7 January 2021

Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older

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7 January 2021

Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains

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7 January 2021

Activated release of membrane-anchored TGF-alpha in the absence of cytosol

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7 January 2021

Motor neurons and neurofilaments in sickness and in health

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7 January 2021

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

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7 January 2021

An abnormality of plasma amyloid protein precursor in Alzheimer's disease

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7 January 2021

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

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7 January 2021

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor

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7 January 2021

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide

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7 January 2021

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

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7 January 2021

Beta A4 protein deposition in familial Alzheimer's disease with the mutation in codon 717 of the beta A4 amyloid precursor protein gene and sporadic Alzheimer's disease

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7 January 2021

Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein

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7 January 2021

Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein

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7 January 2021

Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein.

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7 January 2021

Phosphorylation of the polymeric immunoglobulin receptor required for its efficient transcytosis

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7 January 2021

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

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7 January 2021

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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7 January 2021

Okadaic acid: a new probe for the study of cellular regulation

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7 January 2021

Decreased levels of protein kinase C in Alzheimer brain

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7 January 2021

Evidence for lysosomal processing of amyloid beta-protein precursor in cultured cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis

1 reference

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7 January 2021

Clinico-pathologic studies in dementia: nondemented subjects with pathologically confirmed Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Regulated cleavage of Alzheimer beta-amyloid precursor protein in the absence of the cytoplasmic tail

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Selective loss of central cholinergic neurons in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Beta A4 deposits are constant in the brain of the oldest old: an immunocytochemical study of 20 French centenarians

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Cleavage of amyloid beta peptide during constitutive processing of its precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Processing of the beta-amyloid precursor protein carrying the familial, Dutch-type, and a novel recombinant C-terminal mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Altered cleavage and secretion of a recombinant beta-APP bearing the Swedish familial Alzheimer's disease mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Amyloidogenesis in Alzheimer's disease: some possible therapeutic opportunities

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Alzheimer beta/A4-amyloid precursor protein: evidence for putative amyloidogenic fragment

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Secretory processing of the Alzheimer amyloid beta/A4 protein precursor is increased by protein phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Cl- channels in CF: lack of activation by protein kinase C and cAMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Altered processing of Alzheimer amyloid precursor protein in response to neuronal degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Familial Alzheimer's disease. A pedigree with a mis-sense mutation in the amyloid precursor protein gene (amyloid precursor protein 717 valine-->glycine).

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Serine phosphorylation of the secreted extracellular domain of APP.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Familial Alzheimer's disease with the amyloid precursor protein position 717 mutation and sporadic Alzheimer's disease have the same cytoskeletal pathology.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Regulation of chloride channels by protein kinase C in normal and cystic fibrosis airway epithelia

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Receptor-mediated regulation of constitutive secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Pathological changes in the brain of a patient with familial Alzheimer's disease having a missense mutation at codon 717 in the amyloid precursor protein gene

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

"Secretase," Alzheimer amyloid protein precursor secreting enzyme is not sequence-specific

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Protein kinase C alteration is an early biochemical marker in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

beta-Amyloid precursor protein and Alzheimer's disease: the peptide plot thickens

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Mis-sense mutation Val&rarr;Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

The beta-amyloid precursor protein is not processed by the regulated secretory pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Human lysozyme gene mutations cause hereditary systemic amyloidosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Complement activation by beta-amyloid in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Phosphorylation fails to activate chloride channels from cystic fibrosis airway cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfate

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Beta-amyloid precursor protein cleavage by a membrane-bound protease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Phosphorylation of Alzheimer amyloid precursor protein by protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Alzheimer's mutation.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Reduced protein kinase C immunoreactivity and altered protein phosphorylation in Alzheimer's disease fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis-Dutch type share a decrease in cerebrospinal fluid levels of amyloid beta-protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Activation of chloride channels in normal and cystic fibrosis airway epithelial cells by multifunctional calcium/calmodulin-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2808%2960302-5

7 January 2021

10.1016/S0074-7742(08)60302-5

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