(Q40585555)

21 September 2017

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title

More to learn from gene knockouts (English)

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21 September 2017

B S Shastry

1

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21 September 2017

1 July 1994

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Molecular and Cellular Biochemistry

21 September 2017

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21 September 2017

136

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21 September 2017

171-182

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21 September 2017

2

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https://scigraph.springernature.com/pub.10.1007/bf00926078

21 September 2017

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cites work

Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5

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12 December 2020

Constitutive activation of Src family kinases in mouse embryos that lack Csk.

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12 December 2020

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

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12 December 2020

Profound block in thymocyte development in mice lacking p56lck

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12 December 2020

Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis

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12 December 2020

Expression of tenascin in the developing human small intestine

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12 December 2020

Myogenin gene disruption results in perinatal lethality because of severe muscle defect

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12 December 2020

Mice devoid of PrP are resistant to scrapie

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12 December 2020

Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

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12 December 2020

Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene

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12 December 2020

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

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12 December 2020

V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer

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12 December 2020

Osteoclasts express high levels of pp60c-src in association with intracellular membranes

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12 December 2020

Multiple defects of immune cell function in mice with disrupted interferon-gamma genes

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12 December 2020

Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death

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12 December 2020

A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice

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12 December 2020

Bone and haematopoietic defects in mice lacking c-fos

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12 December 2020

Peripherin and the vision thing

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12 December 2020

High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice

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12 December 2020

Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain

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12 December 2020

Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

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12 December 2020

Modification of the apolipoprotein B gene in HepG2 cells by gene targeting

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12 December 2020

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

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12 December 2020

Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

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12 December 2020

Short-term synaptic plasticity is altered in mice lacking synapsin I.

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12 December 2020

Interleukin-10-deficient mice develop chronic enterocolitis

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12 December 2020

Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene

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12 December 2020

The p53 tumour suppressor gene

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12 December 2020

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene

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12 December 2020

Expression of homeo box genes during mouse development: a review

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12 December 2020

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

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12 December 2020

Thymocyte apoptosis induced by p53-dependent and independent pathways.

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12 December 2020

Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development.

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12 December 2020

T cell development in mice lacking the CD3-zeta/eta gene.

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12 December 2020

CD8 is needed for development of cytotoxic T cells but not helper T cells

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12 December 2020

Modified hippocampal long-term potentiation in PKCγ-mutant mice

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12 December 2020

Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates

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12 December 2020

WT-1 is required for early kidney development

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12 December 2020

Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone

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12 December 2020

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

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12 December 2020

Retinoic acid and craniofacial development: molecules and morphogenesis

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12 December 2020

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

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12 December 2020

Recent experiments with MHC knock-out mice: more questions than answers

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12 December 2020

c-Jun is essential for normal mouse development and hepatogenesis

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12 December 2020

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells

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12 December 2020

The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system

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12 December 2020

Subtle Cerebellar Phenotype in Mice Homozygous for a Targeted Deletion of the En-2 Homeobox

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12 December 2020

Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice

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12 December 2020

Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization

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12 December 2020

Cystic fibrosis in the mouse by targeted insertional mutagenesis

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12 December 2020

Can genes be truly redundant?

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12 December 2020

The cell biology of transforming growth factor beta

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12 December 2020

Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis

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12 December 2020

Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning

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12 December 2020

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.

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12 December 2020

Generation and analysis of interleukin-4 deficient mice

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12 December 2020

A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice

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12 December 2020

p53 is required for radiation-induced apoptosis in mouse thymocytes

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12 December 2020

Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes

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12 December 2020

Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouse

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12 December 2020

Altering the genome by homologous recombination

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12 December 2020

Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice

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12 December 2020

Why isn't a mouse more like a man?

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12 December 2020

Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments

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12 December 2020

Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene

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12 December 2020

A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene

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12 December 2020

Mice lacking TdT: mature animals with an immature lymphocyte repertoire

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12 December 2020

Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6

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12 December 2020

Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice

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12 December 2020

Pleiotropic effects of a null mutation in the c-fos proto-oncogene

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12 December 2020

Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine

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12 December 2020

Requirement for CD8 beta chain in positive selection of CD8-lineage T cells

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12 December 2020

Mice develop normally without tenascin

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12 December 2020

Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons

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12 December 2020

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery

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12 December 2020

Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappa

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12 December 2020

Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice.

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12 December 2020

Targeted disruption of the neuronal nitric oxide synthase gene.

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12 December 2020

Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

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12 December 2020

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

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12 December 2020

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

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12 December 2020

Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation.

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12 December 2020

A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts

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12 December 2020

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

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12 December 2020

MyoD or Myf-5 is required for the formation of skeletal muscle

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12 December 2020

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

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12 December 2020

p53 and DNA polymerase alpha compete for binding to SV40 T antigen

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12 December 2020

Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.

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12 December 2020

Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.

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12 December 2020

Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs

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12 December 2020

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

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12 December 2020

Retinoic acid embryopathy

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12 December 2020

TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice.

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12 December 2020

Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death

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12 December 2020

Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest

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12 December 2020

Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse

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12 December 2020

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

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12 December 2020

Redundancies, development and the flow of information

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12 December 2020

Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice

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12 December 2020

Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene

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12 December 2020

Development and function of T cells in mice with a disrupted CD2 gene

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12 December 2020

Mice lacking MHC class II molecules

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12 December 2020

Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation

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12 December 2020

Gene knockouts of c-src, transforming growth factor beta 1, and tenascin suggest superfluous, nonfunctional expression of proteins

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12 December 2020

Mice lacking major histocompatibility complex class I and class II molecules

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12 December 2020

Mice lacking the MHC class II-associated invariant chain

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12 December 2020

Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons.

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12 December 2020

Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice

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12 December 2020

Differential T cell costimulatory requirements in CD28-deficient mice

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12 December 2020

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12 December 2020

Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins

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12 December 2020

T cell development in mice that lack the zeta chain of the T cell antigen receptor complex

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12 December 2020

Targeting of the T-cell receptor zeta-chain gene in embryonic stem cells: strategies for generating multiple mutations in a single gene

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12 December 2020

FcR gamma chain deletion results in pleiotrophic effector cell defects

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12 December 2020

Disruption of the murine IL-4 gene blocks Th2 cytokine responses.

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12 December 2020

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

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12 December 2020

Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice

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12 December 2020

A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung

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12 December 2020

A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice

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12 December 2020

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

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12 December 2020

Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium

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12 December 2020

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

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12 December 2020

Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene

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12 December 2020

Normal development of mice carrying a null mutation in the gene encoding the L14 S-type lectin

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12 December 2020

PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning.

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12 December 2020

An animal model for cystic fibrosis made by gene targeting

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12 December 2020

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

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12 December 2020

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells

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12 December 2020

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

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12 December 2020

Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning.

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12 December 2020

Hyperuricemia and urate nephropathy in urate oxidase-deficient mice

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12 December 2020

Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.

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12 December 2020

Immune response in mice that lack the interferon-gamma receptor

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12 December 2020

Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion

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12 December 2020

Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells

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12 December 2020

A welcome animal model

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12 December 2020

Requirement for a functional Rb-1 gene in murine development

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12 December 2020

Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop

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12 December 2020

Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1.

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12 December 2020

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

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12 December 2020

Gene disruption in mammals

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12 December 2020

Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination.

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12 December 2020

A death in the life of p53

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12 December 2020

Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations

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12 December 2020

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

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12 December 2020

Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis

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12 December 2020

Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20.

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12 December 2020

Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear

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12 December 2020

Effects of an Rb mutation in the mouse

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12 December 2020

RAG-1-deficient mice have no mature B and T lymphocytes

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12 December 2020

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

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12 December 2020

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

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12 December 2020

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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12 December 2020

Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

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12 December 2020

Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice

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12 December 2020

Animal model of Gaucher's disease from targeted disruption of the mouse glucocerebrosidase gene

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12 December 2020

B cell development in mice that lack one or both immunoglobulin kappa light chain genes.

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12 December 2020

Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans

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12 December 2020

T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes

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12 December 2020

Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain.

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12 December 2020

Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.

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12 December 2020

Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice

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12 December 2020

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

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12 December 2020

Immunoglobulin D-deficient mice can mount normal immune responses to thymus-independent and -dependent antigens

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12 December 2020

Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity

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12 December 2020

Introduction of specific point mutations into RNA polymerase II by gene targeting in mouse embryonic stem cells: evidence for a DNA mismatch repair mechanism

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12 December 2020

Targeted disruption of the mouse cation-dependent mannose 6-phosphate receptor results in partial missorting of multiple lysosomal enzymes.

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12 December 2020

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

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12 December 2020

Disruption of the CNTF gene results in motor neuron degeneration.

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12 December 2020

Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression

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12 December 2020

HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells

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12 December 2020

Tumor suppressor genes

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12 December 2020

Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus.

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12 December 2020

Analysis of homozygous mutant chimeric mice: deletion of the immunoglobulin heavy-chain joining region blocks B-cell development and antibody production

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12 December 2020

Identifiers

DOI

10.1007/BF00926078

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21 September 2017

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PubMed ID

7845371