(Q40599587)

English

Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions.

scientific article published on 13 January 2004

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722114%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722114%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

transmembrane transport

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transmembrane protein

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multiple drug resistance

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based on heuristic

inferred from title

Susan P.C. Cole

5

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17 November 2019

Gwenaëlle Conseil

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Gwenaëlle Conseil

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17 November 2019

4

object named as

Roger G Deeley

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17 November 2019

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Koji Koike

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17 November 2019

Elaine M Leslie

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17 November 2019

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13 January 2004

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17 November 2019

Journal of Biological Chemistry

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17 November 2019

279

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17 November 2019

12325-12336

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17 November 2019

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17 November 2019

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

1 reference

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21 January 2018

The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation

1 reference

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21 January 2018

A family of drug transporters: the multidrug resistance-associated proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters.

1 reference

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21 January 2018

Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus.

1 reference

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21 January 2018

A clinical perspective of cystic fibrosis and new genetic findings: relationship of CFTR mutations to genotype-phenotype manifestations.

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21 January 2018

ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump

1 reference

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21 January 2018

Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1).

1 reference

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21 January 2018

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

1 reference

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21 January 2018

Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1.

1 reference

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21 January 2018

Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Transport of the beta -O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog

1 reference

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21 January 2018

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Multiple membrane-associated tryptophan residues contribute to the transport activity and substrate specificity of the human multidrug resistance protein, MRP1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Charged amino acids in the sixth transmembrane helix of multidrug resistance protein 1 (MRP1/ABCC1) are critical determinants of transport activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

A positively charged amino acid proximal to the C-terminus of TM17 of MRP1 is indispensable for GSH-dependent binding of substrates and for transport of LTC4.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Localization of the GSH‐dependent photolabelling site of an agosterol A analog on human MRP1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): identification of an aspartate residue critical for conversion from a high to low affinity substrate binding sta

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Determinants of the substrate specificity of multidrug resistance protein 1: role of amino acid residues with hydrogen bonding potential in predicted transmembrane helix 17.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Transport of leukotriene C4 by a cysteine-less multidrug resistance protein 1 (MRP1).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Hypothesis about the function of membrane-buried proline residues in transport proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Hinges, swivels and switches: the role of prolines in signalling via transmembrane alpha-helices

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Proline-induced hinges in transmembrane helices: possible roles in ion channel gating

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

The role of a conserved proline residue in mediating conformational changes associated with voltage gating of Cx32 gap junctions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Mutation of proline residues in the NH(2)-terminal region of the multidrug resistance protein, MRP1 (ABCC1): effects on protein expression, membrane localization, and transport function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Comparison of the functional characteristics of the nucleotide binding domains of multidrug resistance protein 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Importance of the conserved Walker B glutamate residues, 556 and 1201, for the completion of the catalytic cycle of ATP hydrolysis by human P-glycoprotein (ABCB1).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Molecular modeling correctly predicts the functional importance of Phe594 in transmembrane helix 11 of the multidrug resistance protein, MRP1 (ABCC1).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Prokink: a protocol for numerical evaluation of helix distortions by proline.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

A second site rescue mutation partially restores functional expression to the serotonin transporter mutant V382P.

1 reference

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21 January 2018

Structure of MsbA from Vibrio cholera: a multidrug resistance ABC transporter homolog in a closed conformation

1 reference

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21 January 2018

ATP binding to the first nucleotide binding domain of multidrug resistance-associated protein plays a regulatory role at low nucleotide concentration, whereas ATP hydrolysis at the second plays a dominant role in ATP-dependent leukotriene C4 transpo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311435200

21 January 2018

Channel-lining residues in the M3 membrane-spanning segment of the cystic fibrosis transmembrane conductance regulator.

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M311435200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722114%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722114%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

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