(Q40601140)

English

Cellular transformation of the investigational new anticancer drug NB1011, a phosphoramidate of 5-(2-bromovinyl)-2'-deoxyuridine, results in modification of cellular proteins not DNA.

scientific article published on March 2003

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scholarly article

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Europe PubMed Central

PubMed publication ID

21 September 2017

Cellular transformation of the investigational new anticancer drug NB1011, a phosphoramidate of 5-(2-bromovinyl)-2'-deoxyuridine, results in modification of cellular proteins not DNA. (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

author name string

Maria V Sergeeva

1

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Brian E Cathers

2

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Europe PubMed Central

PubMed publication ID

21 September 2017

language of work or name

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publication date

1 March 2003

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Europe PubMed Central

PubMed publication ID

21 September 2017

Biochemical Pharmacology

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Europe PubMed Central

PubMed publication ID

21 September 2017

65

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Europe PubMed Central

PubMed publication ID

21 September 2017

5

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Europe PubMed Central

PubMed publication ID

21 September 2017

823-831

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Comparison of 5-fluoro-2'-deoxyuridine with 5-fluorouracil and their role in the treatment of colorectal cancer

1 reference

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A review of the pharmacology and clinical activity of new chemotherapy agents for the treatment of colorectal cancer

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Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil

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Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase

1 reference

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7 January 2021

(E)-5-(2-bromovinyl)uridine requires phosphorylation by the herpes simplex virus (type 1)-induced thymidine kinase to express its antiviral activity

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Comparative activity of selected antiviral compounds against clinical isolates of varicella-zoster virus

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Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives

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Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.

1 reference

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7 January 2021

Resistance to tomudex (ZD1694): multifactorial in human breast and colon carcinoma cell lines

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Drug uptake and cellular targets of hydroxymethylacylfulvene (HMAF)

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Effects on DNA integrity and apoptosis induction by a novel antitumor sesquiterpene drug, 6-hydroxymethylacylfulvene (HMAF, MGI 114)

1 reference

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7 January 2021

Differential cytotoxicity and induction of apoptosis in tumor and normal cells by hydroxymethylacylfulvene (HMAF).

1 reference

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7 January 2021

Identifiers

10.1016/S0006-2952(02)01649-0

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

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