(Q40615810)

English

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

scientific article published on October 1994

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scholarly article

1 reference

Europe PubMed Central

22 September 2017

1 reference

Europe PubMed Central

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane (English)

1 reference

Europe PubMed Central

22 September 2017

1

1 reference

Europe PubMed Central

22 September 2017

author name string

K M Broekemeier

2

1 reference

Europe PubMed Central

22 September 2017

D R Pfeiffer

3

1 reference

Europe PubMed Central

22 September 2017

publication date

1 October 1994

1 reference

Europe PubMed Central

22 September 2017

Journal of Bioenergetics and Biomembranes

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Europe PubMed Central

22 September 2017

26

1 reference

Europe PubMed Central

22 September 2017

509-517

1 reference

Europe PubMed Central

22 September 2017

5

1 reference

Europe PubMed Central

22 September 2017

https://scigraph.springernature.com/pub.10.1007/bf00762735

0 references

Effect of fatty acids on energy coupling processes in mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Partial inhibition by cyclosporin A of the swelling of liver mitochondria in vivo and in vitro induced by sub-micromolar [Ca2+], but not by butyrate. Evidence for two distinct swelling mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. I. Evidence for two separate Me2+ binding sites with opposing effects on the pore open probability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of T-cell signaling pathways by immunophilin drug complexes: are side effects inherent to immunosuppressive properties?

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The presence of two classes of high-affinity cyclosporin A binding sites in mitochondria. Evidence that the minor component is involved in the opening of an inner-membrane Ca(2+)-dependent pore.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The permeability transition in heart mitochondria is regulated synergistically by ADP and cyclosporin A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenylarsine oxide induces the cyclosporin A-sensitive membrane permeability transition in rat liver mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the permeability transition pore, a voltage-dependent mitochondrial channel inhibited by cyclosporin A

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Action of cyclosporine on mitochondrial calcium fluxes

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Permeation of neutral molecules through calcium channel in sarcoplasmic reticulum vesicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition by spermine of the inner membrane permeability transition of isolated rat heart mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective modulation of NMDA responses by reduction and oxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial and glycolytic dysfunction in lethal injury to hepatocytes by t-butylhydroperoxide: protection by fructose, cyclosporin A and trifluoperazine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by matrix pH. Evidence that the pore open-closed probability is regulated by reversible histidine protonation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mitochondrial aspartate/glutamate and ADP/ATP carrier switch from obligate counterexchange to unidirectional transport after modification by SH-reagents

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The NMDA receptor complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Hypothesis for the Role of Dithiol-Disulfide Interchange in Solute Transport and Energy-Transducing Processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium-dependent opening of a non-specific pore in the mitochondrial inner membrane is inhibited at pH values below 7. Implications for the protective effect of low pH against chemical and hypoxic cell damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemiosmotic coupling in oxidative and photosynthetic phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin A protects hepatocytes subjected to high Ca2+ and oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationships between Ca2+ release, Ca2+ cycling, and Ca2+-mediated permeability changes in mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial substrate carriers

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Ca2+-induced membrane transition in mitochondria. I. The protective mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adeni

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptidylproline cis-trans-isomerases: immunophilins

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased permeability of mitochondria during Ca2+ release induced by t-butyl hydroperoxide or oxalacetate. the effect of ruthenium red.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and N-terminal sequencing of peptidyl-prolyl cis-trans-isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The permeability of uncoupled heart mitochondria to potassium ion

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection by cyclosporin A of cultured hepatocytes from the toxic consequences of the loss of mitochondrial energization produced by 1-methyl-4-phenylpyridinium

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the mechanism by which Mg2+ and adenine nucleotides restore membrane potential in rat liver mitochondria deenergized by Ca2+ and phosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mitochondrial permeability transition pore may comprise VDAC molecules. I. Binary structure and voltage dependence of the pore

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-lasting modification of the N-methyl-D-aspartate receptor channel by a voltage-dependent sulfhydryl redox process

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. II. The minimal requirements for pore induction underscore a key role for transmembrane electrical potential, matrix pH, and matrix Ca2+.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Ca2+ transport in brain mitochondria. I. The mechanism of spermine enhancement of Ca2+ uptake and retention.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological effectors modify voltage sensing by the cyclosporin A-sensitive permeability transition pore of mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Magnesium ion modulates the sensitivity of the mitochondrial permeability transition pore to cyclosporin A and ADP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the ADP/ATP carrier in calcium-induced perturbations of the mitochondrial inner membrane permeability: importance of the orientation of the nucleotide binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Ca2+-induced membrane transition in mitochondria. II. Nature of the Ca2+ trigger site

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Ca2+ transport in brain mitochondria. II. The mechanism of the adenine nucleotides enhancement of Ca2+ uptake and retention.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pore-like and carrier-like properties of the mitochondrial aspartate/glutamate carrier after modification by SH-reagents: evidence for a preformed channel as a structural requirement of carrier-mediated transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spermine inhibition of the permeability transition of isolated rat liver mitochondria: an investigation of mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms by which mitochondria transport calcium

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin A-sensitive and insensitive mechanisms produce the permeability transition in mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of phospholipase A2 inhibitors on ruthenium red-induced Ca2+ release from mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstration of the relation between the adenine nucleotide carrier and the structural changes of mitochondria as induced by adenosine 5'-diphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunosuppressive activity and toxicity of cyclosporine metabolites characterized by mass spectroscopy and nuclear magnetic resonance

1 reference

https://pubmed.ncbi.nlm.nih.gov/7896766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00762735

1 reference

Europe PubMed Central

22 September 2017

1 reference

Europe PubMed Central

22 September 2017

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